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1.发明申请METHOD OF MAKING SOLID DISPERSIONS OF HIGHLY CRYSTALLINE THERAPEUTIC COMPOUNDS 有权制备高结晶治疗化合物固体分散体的方法公开(公告)号：US20120190667A1
公开(公告)日：2012-07-26
申请号：US13423329
申请日：2012-03-19
IPC分类号： A61K31/553 , B29C47/00 , B29C67/24
CPC分类号： A61K9/1641
摘要： A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers.
摘要翻译： 制备高度结晶化合物的固体分散体的方法。 高度结晶或热不稳定的治疗化合物在挤出机中与增溶剂和任选的增塑剂组合加工。 所得挤出物的特征在于处于非晶状态的治疗化合物。 增溶剂特别有用的是表面活性剂如泊洛沙姆。
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2.发明授权Method of making solid dispersions of highly crystalline therapeutic compounds 有权制备高度结晶治疗化合物的固体分散体的方法公开(公告)号：US08641948B2
公开(公告)日：2014-02-04
申请号：US13423329
申请日：2012-03-19
CPC分类号： A61K9/1641
摘要： A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers.
摘要翻译： 制备高度结晶化合物的固体分散体的方法。 高度结晶或热不稳定的治疗化合物在挤出机中与增溶剂和任选的增塑剂组合加工。 所得挤出物的特征在于处于非晶状态的治疗化合物。 增溶剂特别有用的是表面活性剂如泊洛沙姆。
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3.发明申请METHOD OF MAKING SOLID DISPERSIONS OF HIGHLY CRYSTALLINE THERAPEUTIC COMPOUNDS 审中-公开制备高结晶治疗化合物固体分散体的方法公开(公告)号：US20100038816A1
公开(公告)日：2010-02-18
申请号：US12376692
申请日：2007-08-14
IPC分类号： B29C47/00
CPC分类号： A61K9/1641
摘要： A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers.
摘要翻译： 制备高度结晶化合物的固体分散体的方法。 高度结晶或热不稳定的治疗化合物在挤出机中与增溶剂和任选的增塑剂组合加工。 所得挤出物的特征在于处于非晶状态的治疗化合物。 增溶剂特别有用的是表面活性剂如泊洛沙姆。
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