公开(公告)号：US20100038816A1

公开(公告)日：2010-02-18

申请号：US12376692

申请日：2007-08-14

申请人： Indrajit Ghogh ,  Jennifer Snyder ,  Wei-Quin Tong ,  Sudha Vippagunta

发明人： Indrajit Ghogh ,  Jennifer Snyder ,  Wei-Quin Tong ,  Sudha Vippagunta

IPC分类号： B29C47/00

CPC分类号： A61K9/1641

摘要： A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers.

摘要翻译： 制备高度结晶化合物的固体分散体的方法。 高度结晶或热不稳定的治疗化合物在挤出机中与增溶剂和任选的增塑剂组合加工。 所得挤出物的特征在于处于非晶状态的治疗化合物。 增溶剂特别有用的是表面活性剂如泊洛沙姆。