公开(公告)号：US07652009B2

公开(公告)日：2010-01-26

申请号：US11289659

申请日：2005-11-29

Applicant: Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Noel D'Angelo ,  Celia Dominguez ,  Ingrid Fellows ,  Matthew Lee ,  Longbin Liu ,  Elizabeth Rainbeau ,  Aaron C. Siegmund ,  Andrew Tasker ,  Ning Xi ,  Yuan Cheng

Inventor： Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Noel D'Angelo ,  Celia Dominguez ,  Ingrid Fellows ,  Matthew Lee ,  Longbin Liu ,  Elizabeth Rainbeau ,  Aaron C. Siegmund ,  Andrew Tasker ,  Ning Xi ,  Yuan Cheng

IPC: A61K31/506 ,  C07D401/02 ,  C07D239/22

CPC classification number: C07D401/14 ,  C07D215/233 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12

Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract translation: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US20060084698A1

公开(公告)日：2006-04-20

申请号：US11235657

申请日：2005-09-26

Applicant: Laurence Hurley ,  Ingrid Fellows ,  Michael Schwaebe ,  Jeffrey Whitten

Inventor： Laurence Hurley ,  Ingrid Fellows ,  Michael Schwaebe ,  Jeffrey Whitten

IPC: A61K31/353 ,  C07D493/02

CPC classification number: C07D493/04

Abstract: Psorospermin is a cytotoxic dihydrofuranoxanthone that has found to exhibit significant activity against various tumor cell lines. Unfortunately, psorospermin is no longer readily available from its natural plant source. The present invention is directed to a method for preparing psorospermin and psorospermin analogs. Methods are also disclosed for utilizing psorospermin analogs to inhibit cellular proliferation.

Abstract translation: Psorospermin是一种细胞毒性的二氢呋喃酮，其发现对各种肿瘤细胞系表现出显着的活性。 不幸的是，它的天然植物来源不再容易获得磷灰石。 本发明涉及一种制备皮尔斯敏精和磷灰石类似物的方法。 还公开了利用磷灰石类似物抑制细胞增殖的方法。

公开(公告)号：US20070054903A1

公开(公告)日：2007-03-08

申请号：US11479187

申请日：2006-06-30

Applicant: Tae-Seong Kim ,  Jean-Christophe Harmange ,  Steven Bellon ,  Shon Booker ,  Noel D'Angelo ,  Celia Dominguez ,  Ingrid Fellows ,  Julie Germain ,  Timothy Harvey ,  Joseph Kim ,  Matthew Lee ,  Longbin Liu ,  Vinod Patel ,  Andrew Tasker

Inventor： Tae-Seong Kim ,  Jean-Christophe Harmange ,  Steven Bellon ,  Shon Booker ,  Noel D'Angelo ,  Celia Dominguez ,  Ingrid Fellows ,  Julie Germain ,  Timothy Harvey ,  Joseph Kim ,  Matthew Lee ,  Longbin Liu ,  Vinod Patel ,  Andrew Tasker

IPC: A61K31/538 ,  A61K31/5377 ,  A61K31/4709 ,  C07D403/02 ,  C07D413/02

CPC classification number: C07D333/38 ,  C07D217/02 ,  C07D217/24 ,  C07D401/10 ,  C07D401/12 ,  C07D409/12 ,  C07D417/10 ,  C07D417/12

Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract translation: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US07244760B2

公开(公告)日：2007-07-17

申请号：US10152152

申请日：2002-05-20

Applicant: Laurence Hurley ,  Ingrid Fellows ,  Michael Kenric Schwaebe ,  Jeffrey Paul Whitten

Inventor： Laurence Hurley ,  Ingrid Fellows ,  Michael Kenric Schwaebe ,  Jeffrey Paul Whitten

IPC: C07D311/80 ,  C07D311/82 ,  A61K31/35

CPC classification number: C07D493/04

Abstract: Psorospermin is a cytotoxic dihydroflranoxanthone that has found to exhibit significant activity against various tumor cell lines. Unfortunately, psorospermin is no longer readily available from its natural plant source. The present invention is directed to a method for preparing psorospermin and psorospermin analogs. Methods are also disclosed for utilizing psorospermin analogs to inhibit cellular proliferation.

Abstract translation: Psorospermin是已发现对各种肿瘤细胞系具有显着活性的细胞毒性二氢弗硝西酮。 不幸的是，它的天然植物来源不再容易获得磷灰石。 本发明涉及一种制备皮尔斯敏精和磷灰石类似物的方法。 还公开了利用磷灰石类似物抑制细胞增殖的方法。

公开(公告)号：US20060252777A1

公开(公告)日：2006-11-09

申请号：US11289659

申请日：2005-11-29

Applicant: Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Noel D'Angelo ,  Celia Dominguez ,  Ingrid Fellows ,  Matthew Lee ,  Longbin Liu ,  Elizabeth Rainbeau ,  Aaron Siegmund ,  Andrew Tasker ,  Ning Xi ,  Yuan Cheng

Inventor： Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Noel D'Angelo ,  Celia Dominguez ,  Ingrid Fellows ,  Matthew Lee ,  Longbin Liu ,  Elizabeth Rainbeau ,  Aaron Siegmund ,  Andrew Tasker ,  Ning Xi ,  Yuan Cheng

IPC: A61K31/519 ,  A61K31/517 ,  A61K31/513 ,  A61K31/4709 ,  A61K31/4745 ,  C07D403/04 ,  C07D487/02 ,  C07D471/02

CPC classification number: C07D401/14 ,  C07D215/233 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12

Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract translation: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。