公开(公告)号：US20240001107A1

公开(公告)日：2024-01-04

申请号：US18216767

申请日：2023-06-30

申请人： Vinod Patel ,  Iosif Gulkarov

发明人： Vinod Patel ,  Iosif Gulkarov

IPC分类号： A61M60/886 ,  A61M60/38 ,  A61M60/13 ,  A61M1/32

CPC分类号： A61M60/886 ,  A61M60/38 ,  A61M60/13 ,  A61M1/32 ,  A61M2205/15

摘要： The present disclosure relates to intracorporeal gas exchange systems and methods in conditions associated with hypoxia and hypercarbia. The present disclosure envisages an intracorporeal oxygenation system comprising a blood oxygenator having a blood compartment and a gas compartment. The blood and gas compartments are separated by a gas permeable barrier so as to allow exchange of carbon dioxide in blood in the blood compartment with oxygen in the gas compartment. The system comprises a catheter device for insertion in a blood vessel of human comprising an interior portion and an exterior portion wherein the interior portion (100a) comprises an annular housing, a plurality of capillary conduit, a pumping device, an air sensing device, a blood sensor and a collar. The present disclosure also relates to a method of oxygenating a deoxygenated blood in a human and also to a method for treating a human suffering from hypoxia or hypercarbia.

公开(公告)号：US11850436B2

公开(公告)日：2023-12-26

申请号：US17521200

申请日：2021-11-08

申请人： Vinod Patel ,  Neel Patel

发明人： Vinod Patel ,  Neel Patel

IPC分类号： A61H31/00 ,  A61N1/39 ,  A61B5/00 ,  A61B5/024 ,  A61B5/1455 ,  A61H3/00 ,  A61H9/00 ,  A61H11/00

CPC分类号： A61N1/39044 ,  A61B5/02416 ,  A61B5/1455 ,  A61B5/747 ,  A61H3/00 ,  A61H9/0078 ,  A61H31/006 ,  A61N1/3987 ,  A61H2011/005 ,  A61H2201/0103 ,  A61H2201/0192 ,  A61H2201/10 ,  A61H2201/1238 ,  A61H2201/165 ,  A61H2201/1621 ,  A61H2201/501 ,  A61H2201/5007 ,  A61H2201/5043 ,  A61H2203/0456 ,  A61H2230/065 ,  A61H2230/201 ,  A61H2230/207

摘要： A cardiopulmonary resuscitation (CPR) device for performing automatic defibrillation and chest compressions on a patient and method for using same. The CPR device having a balloon configured to inflate/deflate, a belt configured to securely strap around a chest of a patient, a pair of electrode pads configured to deliver shock energy from a shock source, and, optionally, a pulse oximeter sensor. The CPR device is in electrical communication with a CPR defibrillator/ECG computer system that is configured to control the CPR device.

公开(公告)号：US08469044B1

公开(公告)日：2013-06-25

申请号：US13085558

申请日：2011-04-13

申请人： Vinod Patel

发明人： Vinod Patel

IPC分类号： A45B25/18 ,  A45B25/22

CPC分类号： A45B25/18 ,  A45B25/20 ,  A45B25/22

摘要： The umbrella includes a shaft, a lower canopy having a central opening, and an upper canopy thereabove over the opening. A first supporting assembly includes ribs, stretchers, and a runner and is connected to the shaft and first and second canopies to operably move the canopies between closed and open positions, wherein an inner portion of the upper canopy moves with the ribs. A second supporting assembly is connected to the ribs of the first assembly within the opening and connected to an outer portion of the upper canopy for operably moving the outer portion of the upper canopy between concave and convex positions while the lower canopy and inner portion of the upper canopy are retained in the concave position, such that the outer portion of the upper canopy covers the opening when concave to restrict air passage and exposes the opening when convex to permit air passage.

摘要翻译： 伞包括一个轴，一个具有中心开口的下盖，以及在其上方的上部顶盖。 第一支撑组件包括肋，拉伸器和流道，并且连接到轴和第一和第二顶盖，以在封闭和打开位置之间可操作地移动檐篷，其中上部顶盖的内部部分与肋移动。 第二支撑组件在开口内连接到第一组件的肋，并且连接到上冠层的外部部分，用于可操作地使上冠盖的外部部分在凹凸位置之间运动，同时下冠盖和内冠部分 上冠盖保持在凹形位置，使得当上凹部的外部部分在凹入时覆盖开口以限制空气通过并且当凸起时露出开口以允许空气通过。

公开(公告)号：US20110106556A1

公开(公告)日：2011-05-05

申请号：US12987990

申请日：2011-01-10

申请人： Bimal Vinod Patel ,  Cynthia Chiyemi Yamaga ,  Louis Leo Brunetti

发明人： Bimal Vinod Patel ,  Cynthia Chiyemi Yamaga ,  Louis Leo Brunetti

IPC分类号： G06Q50/00

CPC分类号： G06F19/345 ,  G06F19/00 ,  G06F19/3456 ,  G06Q50/22 ,  G16H50/20

摘要： Systems and techniques are disclosed for determining an intervention for a patient based at least in part on a likelihood of the patient to adhere to a prescription. In some implementations, a patient profile for a patient is obtained from one or more computer-readable storage devices in a patient population, the patient profile including multiple patient attributes; an adherence score is obtained for the patient profile, the adherence score for predicting patient adherence based on one or more of the multiple patient attributes wherein the adherence score indicates a likelihood of adherence of the patient to a prescribed treatment; and the adherence score obtained for the patient profile is modified into a modified score for intervention based on a set of weights for weighting the patient attributes.

摘要翻译： 公开了用于至少部分地基于患者坚持处方的可能性来确定患者干预的系统和技术。 在一些实施方式中，从患者群体中的一个或多个计算机可读存储设备获得患者的患者简档，患者简档包括多个患者属性; 获得患者资料的依从性分数，用于基于多个患者属性中的一个或多个来预测患者依从性的依从性评分，其中所述依从性分数表示患者遵守规定治疗的可能性; 并且基于用于加权患者属性的一组权重将针对患者简档获得的遵守得分修改为用于干预的修改得分。

公开(公告)号：US20070054916A1

公开(公告)日：2007-03-08

申请号：US11240590

申请日：2005-09-30

申请人： Vinod Patel ,  Joseph Kim ,  Stephanie Geuns-Meyer ,  Stuart Chaffee ,  Victor Cee ,  Brian Hodous ,  Steven Bellon ,  Jean-Christophe Harmange ,  Philip Olivieri ,  Maya Thaman ,  Erin DiMauro ,  John Buchanan ,  David McGowan ,  Brian Albrecht ,  Holly Deak ,  Jean Bemis ,  Ryan White ,  Matthew Martin ,  Gregory Habgood ,  Paul Tempest ,  Craig Masse ,  William Buckner ,  Bradley Herberich ,  Russell Graceffa ,  Dawei Zhang ,  Shimin Xu ,  Kelvin Sham ,  Robert Rzasa ,  James Falsey ,  Partha Chakrabarti ,  Guo-Qiang Cao ,  Susan Tomlinson ,  Liping Pettus ,  Adrian Smith ,  Nick Paras ,  Gang Liu ,  Frenel DeMorin ,  Andrew Tasker ,  Anthony Reed

发明人： Vinod Patel ,  Joseph Kim ,  Stephanie Geuns-Meyer ,  Stuart Chaffee ,  Victor Cee ,  Brian Hodous ,  Steven Bellon ,  Jean-Christophe Harmange ,  Philip Olivieri ,  Maya Thaman ,  Erin DiMauro ,  John Buchanan ,  David McGowan ,  Brian Albrecht ,  Holly Deak ,  Jean Bemis ,  Ryan White ,  Matthew Martin ,  Gregory Habgood ,  Paul Tempest ,  Craig Masse ,  William Buckner ,  Bradley Herberich ,  Russell Graceffa ,  Dawei Zhang ,  Shimin Xu ,  Kelvin Sham ,  Robert Rzasa ,  James Falsey ,  Partha Chakrabarti ,  Guo-Qiang Cao ,  Susan Tomlinson ,  Liping Pettus ,  Adrian Smith ,  Nick Paras ,  Gang Liu ,  Frenel DeMorin ,  Andrew Tasker ,  Anthony Reed

IPC分类号： A61K31/525 ,  A61K31/519 ,  A61K31/517

CPC分类号： C07D215/38 ,  C07C205/37 ,  C07D215/12 ,  C07D217/12 ,  C07D217/22 ,  C07D217/26 ,  C07D239/26 ,  C07D239/84 ,  C07D239/94 ,  C07D239/95 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.

摘要翻译： 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症，癌症和相关病症的化合物。 化合物具有通式I，其中A 1，A 2，A 3，B，R 1， R 2，R 3和R 4在本文中定义。 因此，本发明还包括含有本发明化合物的药物组合物，使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

公开(公告)号：US20070054903A1

公开(公告)日：2007-03-08

申请号：US11479187

申请日：2006-06-30

申请人： Tae-Seong Kim ,  Jean-Christophe Harmange ,  Steven Bellon ,  Shon Booker ,  Noel D'Angelo ,  Celia Dominguez ,  Ingrid Fellows ,  Julie Germain ,  Timothy Harvey ,  Joseph Kim ,  Matthew Lee ,  Longbin Liu ,  Vinod Patel ,  Andrew Tasker

发明人： Tae-Seong Kim ,  Jean-Christophe Harmange ,  Steven Bellon ,  Shon Booker ,  Noel D'Angelo ,  Celia Dominguez ,  Ingrid Fellows ,  Julie Germain ,  Timothy Harvey ,  Joseph Kim ,  Matthew Lee ,  Longbin Liu ,  Vinod Patel ,  Andrew Tasker

IPC分类号： A61K31/538 ,  A61K31/5377 ,  A61K31/4709 ,  C07D403/02 ,  C07D413/02

CPC分类号： C07D333/38 ,  C07D217/02 ,  C07D217/24 ,  C07D401/10 ,  C07D401/12 ,  C07D409/12 ,  C07D417/10 ,  C07D417/12

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US20070049592A1

公开(公告)日：2007-03-01

申请号：US11506693

申请日：2006-08-18

申请人： Stephanie Geuns-Meyer ,  Stuart Chaffee ,  Rebecca Johnson ,  Joseph Kim ,  Joseph Nunes ,  Vinod Patel

发明人： Stephanie Geuns-Meyer ,  Stuart Chaffee ,  Rebecca Johnson ,  Joseph Kim ,  Joseph Nunes ,  Vinod Patel

IPC分类号： A61K31/5377 ,  A61K31/53 ,  A61K31/506 ,  A61K31/4709 ,  C07D413/02 ,  C07D403/02 ,  C07D401/02

CPC分类号： C07D213/81 ,  C07D213/75 ,  C07D239/42 ,  C07D239/48 ,  C07D239/74 ,  C07D239/94 ,  C07D251/18 ,  C07D251/48 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04

摘要： The present invention relates to compounds of Formulas I and II, wherein A1, A2, B1, B2, Q, X1, X2, Y and R3 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.

摘要翻译： 本发明涉及式I和II的化合物，其中A 1，A 2，B 1，B 2， 本文定义了本文所定义的含有这些化合物的合成中间体和药物组合物，其中，Q，X 1，X 2，Y和R 3， 。 化合物和组合物能够调节各种蛋白激酶受体如Tie-2，因此影响激酶相关的疾病状态和状况。 该化合物例如能够治疗由不受调节的血管发生，炎症以及其它增殖性疾病引起的癌症。

公开(公告)号：US20060040966A1

公开(公告)日：2006-02-23

申请号：US11185556

申请日：2005-07-19

申请人： Chester Yuan ,  Kevin Yang ,  Simon Van Der Plas ,  Babak Riahi ,  Michele Potashman ,  Vinod Patel ,  Rana Nomak ,  Aiwen Li ,  Qi Huang ,  Jean-Christophe Harmange ,  Benny Askew

发明人： Chester Yuan ,  Kevin Yang ,  Simon Van Der Plas ,  Babak Riahi ,  Michele Potashman ,  Vinod Patel ,  Rana Nomak ,  Aiwen Li ,  Qi Huang ,  Jean-Christophe Harmange ,  Benny Askew

IPC分类号： A61K31/517 ,  A61K31/4433 ,  C07D405/02 ,  C07D401/02

CPC分类号： C07D401/12 ,  C07D217/02 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds of Formula I and II wherein R, R1 and R2 for each formula are defined herein. The invention further includes analogs, prodrugs and pharmaceutically acceptable salts and derivatives of Formulas I and II, as well as pharmaceutical compositions, medicaments and methods thereof for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 选择的胺对于预防和治疗疾病如血管生成介导的疾病是有效的。 本发明包括式I和II的新型化合物，其中R 1，R 1和R 2各自在本文中定义。 本发明还包括式I和II的类似物，前药和药学上可接受的盐和衍生物，以及用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物，药物及其方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US20050203114A1

公开(公告)日：2005-09-15

申请号：US11125614

申请日：2005-05-09

申请人： David Armistead ,  Jean Bemis ,  Lucian DiPietro ,  Stephanie Geuns-Meyer ,  Gregory Habgood ,  Joseph Kim ,  Joseph Nunes ,  Vinod Patel ,  Leticia Toledo-Sherman

发明人： David Armistead ,  Jean Bemis ,  Lucian DiPietro ,  Stephanie Geuns-Meyer ,  Gregory Habgood ,  Joseph Kim ,  Joseph Nunes ,  Vinod Patel ,  Leticia Toledo-Sherman

IPC分类号： C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  A61P1/04 ,  A61P3/00 ,  A61P3/10 ,  A61P9/00 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  A61K31/513

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

摘要： The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.

摘要翻译： 本发明涉及激酶抑制剂，包含抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备激酶抑制剂化合物的方法，抑制激酶活性的方法，以及治疗疾病或疾病症状的方法。

公开(公告)号：US4082451A

公开(公告)日：1978-04-04

申请号：US634017

申请日：1975-11-21

申请人： Vinod Patel

发明人： Vinod Patel

IPC分类号： G03G15/04 ,  G03B27/76

CPC分类号： G03G15/04027

摘要： Apparatus for providing a structured radiation pattern in a charge distribution of a photoreceptor. The apparatus is comprised of a source of radiation, a plurality of apertures and a lens system for focusing the illumination, by the apertures, on the photoreceptor. The lens system is arranged to provide an overlapping of the aperture images formed on the photoreceptor. The overlapping images minimize the requirement on the intensity of radiation from the radiation source. The position of the apparatus from the photoreceptor provides a method for control of the size of the structured pattern on the photoreceptor charge. A line structure or a dot structure pattern can be applied to the charge distribution of the photoreceptor.