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1.发明授权Use of a galectin-1-targeted RNAi-based approach for the treatment of cancer 有权使用半乳凝素1靶向基于RNAi的方法治疗癌症公开(公告)号：US07964575B2
公开(公告)日：2011-06-21
申请号：US11911342
申请日：2006-03-09
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.
摘要翻译： 本发明涉及适于降低含有SEQ ID NO：1-33的任何序列，优选SEQ ID NO：2,3或4的序列的半乳凝素-1的表达的RNAi分子，并且涉及 或用于制备用于治疗和/或延迟癌症进展的药物，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤 。 本发明还涉及用于治疗和延迟癌症，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤的进展的组合物和方法，用于减少 肿瘤细胞，优选胶质瘤细胞，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，和/或用于增强癌症疗法治疗癌症的功效，优选神经胶质瘤， 胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，选自化疗，放射治疗，免疫治疗和/或基因治疗。
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2.发明申请USE OF A GALECTIN-1-TARGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 有权使用GALECTIN-1靶向基于RNAi的方法治疗癌症公开(公告)号：US20100120891A1
公开(公告)日：2010-05-13
申请号：US11911342
申请日：2006-03-09
IPC分类号： A61K31/7105 , C12N5/071 , C12N15/74 , A61K31/711 , A61P35/00 , A61P35/04
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.
摘要翻译： 本发明涉及适于降低含有SEQ ID NO：1-33的任何序列，优选SEQ ID NO：2,3或4的序列的半乳凝素-1的表达的RNAi分子，并且涉及 或用于制备用于治疗和/或延迟癌症进展的药物，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤 。 本发明还涉及用于治疗和延迟癌症，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤的进展的组合物和方法，用于减少 肿瘤细胞，优选胶质瘤细胞，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，和/或用于增强癌症疗法治疗癌症的功效，优选神经胶质瘤， 胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，选自化疗，放射治疗，免疫治疗和/或基因治疗。
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