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1.发明授权Nucleic acid molecule comprising a nucleic acid sequence which codes for a haemocyanin 有权核酸分子，其包含编码血蓝蛋白的核酸序列公开(公告)号：US07282578B2
公开(公告)日：2007-10-16
申请号：US11511952
申请日：2006-08-29
IPC分类号： C07H21/00
CPC分类号： C07K14/43504 , A61K39/0003 , A61K2039/6081 , Y02A50/423 , Y10S530/855
摘要： A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a KLH1 haemocyanin, a haemocyanin domain or a fragment thereof with the immunological properties of at least one domain of haemocyanin, and comprises at least one intron sequence, as well as haemocyanin fusion proteins. The construct can also comprise a nucleic acid sequence that codes for an antigen. Host cells are also contemplated that contain the nucleic acid molecule or construct and a recombinant expression product thereof. The invention further relates to a pharmaceutical composition that comprises the expression product and antibodies obtainable by immunization of an animal therewith, as well as the use of antibodies in screening methods for the identification of tumors.
摘要翻译： 预期单独或具有适用于表达控制的启动子的核酸分子或构建体编码具有至少一个血蓝蛋白结构域的免疫学特性的KLH1血蓝蛋白，血蓝蛋白结构域或其片段，并且包含至少一个内含子序列 ，以及血蓝蛋白融合蛋白。 构建体还可以包含编码抗原的核酸序列。 还考虑了含有核酸分子或构建体及其重组表达产物的宿主细胞。 本发明还涉及一种药物组合物，其包含表达产物和通过用其免疫动物可获得的抗体，以及在鉴定肿瘤的筛选方法中使用抗体。
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2.发明授权Nucleic acid molecule comprising a nucleic acid sequence which codes for a haemocyanin, and comprising at least one intron sequence 有权核酸分子，其包含编码血蓝蛋白的核酸序列，并且包含至少一个内含子序列公开(公告)号：US07125557B1
公开(公告)日：2006-10-24
申请号：US10049988
申请日：2000-08-21
CPC分类号： C12Y110/03001 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/43504 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12N9/0059 , G01N33/57496 , Y02A50/423 , Y10S530/855
摘要： A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a haemocyanin, a haemocyanin domain or a fragment thereof with the immunological properties of at least one domain of haemocyanin, and comprises at least one intron sequence, as well as haemocyanin fusion proteins. The construct furthermore can comprise a nucleic acid sequence that codes for an antigen. Host cells are also contemplated that contain the nucleic acid molecule or construct and a recombinant expression product thereof. The invention furthermore relates to a pharmaceutical composition that comprises the expression product and antibodies obtainable by immunization of an animal therewith, as well as the use the antibodies in screening methods for the identification of tumors.
摘要翻译： 预期单独或具有适用于表达控制的启动子的核酸分子或构建体编码具有至少一个血蓝蛋白结构域的免疫学特性的血蓝蛋白，血蓝蛋白结构域或其片段，并且包含至少一个内含子序列， 以及血蓝蛋白融合蛋白。 该构建体还可以包含编码抗原的核酸序列。 还考虑了含有核酸分子或构建体及其重组表达产物的宿主细胞。 本发明还涉及一种药物组合物，其包含表达产物和通过用其免疫动物可获得的抗体，以及在用于鉴定肿瘤的筛选方法中使用该抗体。
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3.发明授权Nucleic acid molecule comprising a nucleic acid sequence coding for a haemocyanin 有权包含编码血蓝蛋白的核酸序列的核酸分子公开(公告)号：US07125556B1
公开(公告)日：2006-10-24
申请号：US09936852
申请日：2000-03-17
CPC分类号： C07K14/43504 , A61K39/0003 , A61K2039/6081 , Y02A50/423 , Y10S530/855
摘要： A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a haemocyanin, a haemocyanin domain or a fragment thereof with the immunological properties of at least one domain of haemocyanin, and comprises at least one intron sequence, as well as haemocyanin fusion proteins. The construct furthermore can comprise a nucleic acid sequence that codes for an antigen. Host cells are also contemplated that contain the nucleic acid molecule or construct and a recombinant expression product thereof. The invention furthermore relates to a pharmaceutical composition that comprises the expression product and antibodies obtainable by immunization of an animal therewith, as well as the use the antibodies in screening methods for the identification of tumors.
摘要翻译： 预期单独或具有适用于表达控制的启动子的核酸分子或构建体编码具有至少一个血蓝蛋白结构域的免疫学特性的血蓝蛋白，血蓝蛋白结构域或其片段，并且包含至少一个内含子序列， 以及血蓝蛋白融合蛋白。 该构建体还可以包含编码抗原的核酸序列。 还考虑了含有核酸分子或构建体及其重组表达产物的宿主细胞。 本发明还涉及一种药物组合物，其包含表达产物和通过用其免疫动物可获得的抗体，以及在用于鉴定肿瘤的筛选方法中使用该抗体。
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4.发明授权Nucleic acid molecule comprising a nucleic acid sequence coding for a haemocyanin 有权包含编码血蓝蛋白的核酸序列的核酸分子公开(公告)号：US07273928B2
公开(公告)日：2007-09-25
申请号：US11512044
申请日：2006-08-29
申请人： Jürgen Markl , Benjamin Altenhein , Bernard Lieb , Thomas Stiefel
发明人： Jürgen Markl , Benjamin Altenhein , Bernard Lieb , Thomas Stiefel
IPC分类号： C07H21/00
CPC分类号： C12Y110/03001 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/43504 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12N9/0059 , G01N33/57496 , Y02A50/423 , Y10S530/855
摘要： A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a HLH2 haemocyanin polypeptide and comprises at least one intron sequence, as well as haemocyanin fusion proteins. The construct further can comprise a nucleic acid sequence that codes for an antigen. Host cells are also contemplated that contain the nucleic acid molecules or construct and recombinant expression product thereof. The invention further relates to a pharmaceutical composition that comprises the expression product of that nucleic acid and antibodies obtainable by immunization of an animal therewith, as well as use of the antibodies in screening methods for the identification of tumors.
摘要翻译： 预期单独的或具有适用于表达控制的启动子的核酸分子或构建体编码HLH2血蓝蛋白多肽并且包含至少一个内含子序列以及血蓝蛋白融合蛋白。 构建体还可以包含编码抗原的核酸序列。 还考虑含有核酸分子或其构建体和重组表达产物的宿主细胞。 本发明进一步涉及药物组合物，其包含该核酸的表达产物和通过用其免疫动物可获得的抗体，以及在筛选鉴定肿瘤的方法中使用该抗体。
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