公开(公告)号：US5776946A

公开(公告)日：1998-07-07

申请号：US520211

申请日：1995-08-28

申请人： Patrick L. McGeer ,  J. Douglas Waterfield ,  Edith G. McGeer

发明人： Patrick L. McGeer ,  J. Douglas Waterfield ,  Edith G. McGeer

IPC分类号： A61K31/5513 ,  A61K31/47

CPC分类号： A61K31/472 ,  A61K31/4725 ,  A61K31/5513

摘要： Compounds which bind with high affinity to peripheral benzodiazepine receptors are useful as antiinflammatory agents. Such compounds include isoquinoline and benzodiazepine derivatives, such as PK 11195. A method of treating an inflammatory condition in a mammal with such compounds is provided. Pharmaceutical compositions comprising such compounds are provided. A method is provided for identifying compounds that are therapeutically effective for treating inflammatory conditions.

摘要翻译： 与周边苯并二氮杂受体高亲和力结合的化合物可用作抗炎剂。 这样的化合物包括异喹啉和苯并二氮杂衍生物，例如PK11195。提供了一种用这些化合物治疗哺乳动物炎性病症的方法。 提供包含这些化合物的药物组合物。 提供了一种用于鉴定治疗有效治疗炎性病症的化合物的方法。