公开(公告)号：US5776946A

公开(公告)日：1998-07-07

申请号：US520211

申请日：1995-08-28

申请人： Patrick L. McGeer ,  J. Douglas Waterfield ,  Edith G. McGeer

发明人： Patrick L. McGeer ,  J. Douglas Waterfield ,  Edith G. McGeer

IPC分类号： A61K31/5513 ,  A61K31/47

CPC分类号： A61K31/472 ,  A61K31/4725 ,  A61K31/5513

摘要： Compounds which bind with high affinity to peripheral benzodiazepine receptors are useful as antiinflammatory agents. Such compounds include isoquinoline and benzodiazepine derivatives, such as PK 11195. A method of treating an inflammatory condition in a mammal with such compounds is provided. Pharmaceutical compositions comprising such compounds are provided. A method is provided for identifying compounds that are therapeutically effective for treating inflammatory conditions.

摘要翻译： 与周边苯并二氮杂受体高亲和力结合的化合物可用作抗炎剂。 这样的化合物包括异喹啉和苯并二氮杂衍生物，例如PK11195。提供了一种用这些化合物治疗哺乳动物炎性病症的方法。 提供包含这些化合物的药物组合物。 提供了一种用于鉴定治疗有效治疗炎性病症的化合物的方法。

公开(公告)号：US5532219A

公开(公告)日：1996-07-02

申请号：US042658

申请日：1993-04-05

申请人： Patrick L. McGeer ,  Nobua Harada ,  Horoshi Kimura ,  Edith G. McGeer ,  Michael Schulzer

发明人： Patrick L. McGeer ,  Nobua Harada ,  Horoshi Kimura ,  Edith G. McGeer ,  Michael Schulzer

IPC分类号： A61K31/145 ,  A61K31/185 ,  A61K31/426 ,  A61K31/13

CPC分类号： A61K31/426 ,  A61K31/145 ,  A61K31/185

摘要： This invention pertains to the novel use of 4,4'-diaminodiphenylsulfone and its didextrose sulfonate derivative and other closely related sulfones in the prevention and treatment of dementia (Alzheimer's disease). A method of preventing and treating dementia in a human being suffering from dementia which comprises administering to the human being a therapeutic amount of a substance selected from the group consisting of 4,4'-diaminodiphenylsulfone, its didextrose sulfonate derivative, and sulfoxone, sulfetrone and thiazolsulfone, and therapeutically acceptable salts thereof.

摘要翻译： 本发明涉及4,4'-二氨基二苯砜及其二葡萄糖磺酸衍生物及其它密切相关的砜在预防和治疗痴呆症（阿尔茨海默病）中的新用途。 一种预防和治疗患有痴呆症的人的痴呆症的方法，其包括向所述人施用治疗量的选自下组的物质：4,4'-二氨基二苯基砜，其二葡聚糖磺酸酯衍生物和砜酮，磺基和 噻唑砜及其可治疗的盐。