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8 条记录 (耗时 0.021 秒)

    Selective inhibition of the membrane attack complex of complement and C3 convertase by low molecular weight components of the aurin tricarboxylic acid synthetic complex
    4.
    发明申请
    Selective inhibition of the membrane attack complex of complement and C3 convertase by low molecular weight components of the aurin tricarboxylic acid synthetic complex 审中-公开
    选择性抑制补体和C3转化酶的膜攻击复合物由低分子量成分的三元羧酸合成复合物

    公开(公告)号：US20130035392A1

    公开(公告)日：2013-02-07

    申请号：US13541535

    申请日：2012-07-03

    申请人： Patrick L. McGeer ,  Moonhee Lee ,  Jian-Ping Guo ,  Claudia Schwab

    发明人： Patrick L. McGeer ,  Moonhee Lee ,  Jian-Ping Guo ,  Claudia Schwab

    IPC分类号： A61K31/194 ,  A61P25/00 ,  A61P27/02 ,  A61P33/06 ,  A61P25/28 ,  A61P9/10

    CPC分类号： A61K31/194 ,  Y02A50/411

    摘要： It pertains to selective inhibition of C3 convertase of the alternative pathway of complement as well as the previously claimed assembly of the membrane attack complex of complement by use of less than 1 kDa molecular weight forms of the aurin tricarboxylic acid synthetic complex (ATAC), and their derivatives. It further pertains to the use of these materials to treat human conditions where there is evidence of self destruction of host tissue by C3 convertase activation of the alternative complement pathway, or the membrane attack complex, or both pathways. These diseases include, but are not limited to, paroxysmal nocturnal hemoglobinemia, rheumatoid arthritis, multiple sclerosis, malaria infection, Alzheimer disease, age related macular degeneration, and atherosclerosis.

    摘要翻译： 它涉及选择性抑制补体途径的C3转化酶的选择性抑制，以及通过使用小于1kDa分子量形式的神经元三羧酸合成复合物（ATAC）的先前要求的补体膜攻击复合物的组合，以及 他们的衍生品。 它还涉及使用这些材料来治疗人类病症，其中有证据表明通过C3转化酶激活替代补体途径或膜攻击复合物或两种途径的宿主组织的自身破坏。 这些疾病包括但不限于阵发性夜间血红蛋白血症，类风湿性关节炎，多发性硬化，疟疾感染，阿尔茨海默病，年龄相关性黄斑变性和动脉粥样硬化。

    Peripheral benzodiazepine receptor ligands as antiinflammatory agents
    5.
    发明授权
    Peripheral benzodiazepine receptor ligands as antiinflammatory agents 失效
    外周苯并二氮杂受体配体作为抗炎剂

    公开(公告)号：US5776946A

    公开(公告)日：1998-07-07

    申请号：US520211

    申请日：1995-08-28

    申请人： Patrick L. McGeer ,  J. Douglas Waterfield ,  Edith G. McGeer

    发明人： Patrick L. McGeer ,  J. Douglas Waterfield ,  Edith G. McGeer

    IPC分类号： A61K31/5513 ,  A61K31/47

    CPC分类号： A61K31/472 ,  A61K31/4725 ,  A61K31/5513

    摘要： Compounds which bind with high affinity to peripheral benzodiazepine receptors are useful as antiinflammatory agents. Such compounds include isoquinoline and benzodiazepine derivatives, such as PK 11195. A method of treating an inflammatory condition in a mammal with such compounds is provided. Pharmaceutical compositions comprising such compounds are provided. A method is provided for identifying compounds that are therapeutically effective for treating inflammatory conditions.

    摘要翻译： 与周边苯并二氮杂受体高亲和力结合的化合物可用作抗炎剂。 这样的化合物包括异喹啉和苯并二氮杂衍生物，例如PK11195。提供了一种用这些化合物治疗哺乳动物炎性病症的方法。 提供包含这些化合物的药物组合物。 提供了一种用于鉴定治疗有效治疗炎性病症的化合物的方法。

    Dapsone and promin for the treatment of dementia
    7.
    发明授权
    Dapsone and promin for the treatment of dementia 失效
    氨苯砜和突出治疗痴呆症

    公开(公告)号：US5532219A

    公开(公告)日：1996-07-02

    申请号：US042658

    申请日：1993-04-05

    申请人： Patrick L. McGeer ,  Nobua Harada ,  Horoshi Kimura ,  Edith G. McGeer ,  Michael Schulzer

    发明人： Patrick L. McGeer ,  Nobua Harada ,  Horoshi Kimura ,  Edith G. McGeer ,  Michael Schulzer

    IPC分类号： A61K31/145 ,  A61K31/185 ,  A61K31/426 ,  A61K31/13

    CPC分类号： A61K31/426 ,  A61K31/145 ,  A61K31/185

    摘要： This invention pertains to the novel use of 4,4'-diaminodiphenylsulfone and its didextrose sulfonate derivative and other closely related sulfones in the prevention and treatment of dementia (Alzheimer's disease). A method of preventing and treating dementia in a human being suffering from dementia which comprises administering to the human being a therapeutic amount of a substance selected from the group consisting of 4,4'-diaminodiphenylsulfone, its didextrose sulfonate derivative, and sulfoxone, sulfetrone and thiazolsulfone, and therapeutically acceptable salts thereof.

    摘要翻译： 本发明涉及4,4'-二氨基二苯砜及其二葡萄糖磺酸衍生物及其它密切相关的砜在预防和治疗痴呆症（阿尔茨海默病）中的新用途。 一种预防和治疗患有痴呆症的人的痴呆症的方法，其包括向所述人施用治疗量的选自下组的物质：4,4'-二氨基二苯基砜，其二葡聚糖磺酸酯衍生物和砜酮，磺基和 噻唑砜及其可治疗的盐。