公开(公告)号：US07280869B2

公开(公告)日：2007-10-09

申请号：US11004072

申请日：2004-12-03

Applicant: Eduardo N. Warman ,  Jacob D. Feala

Inventor： Eduardo N. Warman ,  Jacob D. Feala

IPC: A61N1/362

CPC classification number: A61N1/3622

Abstract: In general, the invention is directed to an apparatus and method for determining whether an identified atrial tachyarrhythmia episode has terminated. The invention enables determination of whether the tachyarrhythmia episode has terminated based on cardiac beat pattern. In some embodiments of the invention, the determination as to whether the episode has terminated is made irrespective of the rate of atrial depolarizations.

Abstract translation: 通常，本发明涉及用于确定所识别的心房快速性心律失常事件是否已经终止的装置和方法。 本发明能够基于心跳模式确定快速性心律失常发作是否终止。 在本发明的一些实施方案中，无论心房去极化的发生率如何，都确定是否终止该发作。

公开(公告)号：US10095842B2

公开(公告)日：2018-10-09

申请号：US13118395

申请日：2011-05-28

Applicant: Giovanni Paternostro ,  Jacob D Feala

Inventor： Giovanni Paternostro ,  Jacob D Feala

IPC: G06F19/00 ,  C40B50/02 ,  G06F19/12

Abstract: Methods and systems for determining a set of control molecules for use in a combinatorial approach for the treatment of medical conditions, including providing one or more sets of control molecules, where each control molecule within the set acts on a set of targets and the number of control molecules within the one or more sets of control molecules is fewer than the number of targets within the sets of targets; and searching within the sets of control molecules to identify a subset of control molecules that together with a subset of targets form an artificial system to produce a biological effect through the modulation of the subset of targets.

公开(公告)号：US20180318312A1

公开(公告)日：2018-11-08

申请号：US15755225

申请日：2016-08-30

Applicant: Lihua YU ,  Kian Huat LIM ,  Jacob D. FEALA ,  Silvia BUONAMICI ,  Yoshiharu MIZUI ,  Peter G. SMITH ,  Ping ZHU ,  Eunice Sun PARK ,  Michael W. SEILER ,  Marco Peter FEKKES ,  Eisai R&D Management Co., Ltd.

Inventor： Lihua Yu ,  Kian Huat Lim ,  Jacob D. Feala ,  Silvia Buonamici ,  Yoshiharu Mizui ,  Peter G. Smith ,  Ping Zhu ,  Eunice Sun Park ,  Michael W. Seiler ,  Marco Peter Fekkes

IPC: A61K31/55 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/495 ,  C12Q1/6886 ,  C12Q1/02

CPC classification number: A61K31/55 ,  A61K31/4545 ,  A61K31/495 ,  A61P35/00 ,  C12Q1/025 ,  C12Q1/6806 ,  C12Q1/6841 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

公开(公告)号：US20120015834A1

公开(公告)日：2012-01-19

申请号：US13118395

申请日：2011-05-28

Applicant: Giovanni Paternostro ,  Jacob D. Feala

Inventor： Giovanni Paternostro ,  Jacob D. Feala

IPC: C40B30/02

CPC classification number: G06F19/706 ,  C40B50/02 ,  G06F19/12

Abstract: Methods and systems for determining a set of control molecules for use in a combinatorial approach for the treatment of medical conditions, including providing one or more sets of control molecules, where each control molecule within the set acts on a set of targets and the number of control molecules within the one or more sets of control molecules is fewer than the number of targets within the sets of targets; and searching within the sets of control molecules to identify a subset of control molecules that together with a subset of targets form an artificial system to produce a biological effect through the modulation of the subset of targets.

Abstract translation: 用于确定用于治疗医学状况的组合方法中的一组控制分子的方法和系统，包括提供一组或多组对照分子，其中该组内的每个对照分子作用于一组靶标和 一组或多组对照分子内的对照分子少于目标组内目标的数目; 并且在所述控制分子组内搜索以识别控制分子的子集，所述对照分子与靶的子集一起形成人造系统，以通过调整所述靶的子集来产生生物学效应。