公开(公告)号：US20120141488A1

公开(公告)日：2012-06-07

申请号：US13322304

申请日：2009-09-07

Applicant: Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hae Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

Inventor： Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hae Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

IPC: A61K39/395 ,  G01N33/53 ,  G01N33/566 ,  G01N27/447 ,  A61K31/7088 ,  A61P35/00 ,  A61P35/04 ,  C12Q1/68 ,  C12Q1/02

CPC classification number: C07K14/705 ,  G01N33/5041

Abstract: Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.

Abstract translation: 公开了新型GPCR（G蛋白偶联受体）蛋白和编码其的基因。 还提供了蛋白质和基因的使用。 特别地，考虑了新型GPCR（G蛋白偶联受体）多肽，编码它的多核苷酸，携带多核苷酸或其片段的重组载体，用该载体转化的宿主细胞，用载体感染的转基因动物。 另外，含有能够测定GPCR多核苷酸的mRNA或蛋白质的表达量的试剂，癌症诊断用试剂盒，含有该组合物的检测癌标记物的组合物，以及检测GPCR多肽的方法和 提供编码多肽的基因。 此外，用于治疗和预防癌症的组合物包含抑制GPCR多肽或编码GPCR蛋白的抗体表达的寡核苷酸以及筛选GPCR蛋白或癌症治疗剂的调节剂的方法， 提供。

公开(公告)号：US09034327B2

公开(公告)日：2015-05-19

申请号：US13322304

申请日：2009-09-07

Applicant: Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hee Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

Inventor： Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hee Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

IPC: G01N33/53 ,  C07K14/705 ,  G01N33/50

CPC classification number: C07K14/705 ,  G01N33/5041

Abstract: Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.

Abstract translation: 公开了新型GPCR（G蛋白偶联受体）蛋白和编码其的基因。 还提供了蛋白质和基因的使用。 特别地，考虑了新型GPCR（G蛋白偶联受体）多肽，编码它的多核苷酸，携带多核苷酸或其片段的重组载体，用该载体转化的宿主细胞，用载体感染的转基因动物。 另外，含有能够测定GPCR多核苷酸的mRNA或蛋白质的表达量的试剂，癌症诊断用试剂盒，含有该组合物的检测癌标记物的组合物，以及检测GPCR多肽的方法和 提供编码多肽的基因。 此外，用于治疗和预防癌症的组合物包含抑制GPCR多肽或编码GPCR蛋白的抗体表达的寡核苷酸以及筛选GPCR蛋白或癌症治疗剂的调节剂的方法， 提供。