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公开(公告)号:US20130146697A1
公开(公告)日:2013-06-13
申请号:US13605558
申请日:2012-09-06
申请人: Dong Wook Kim , Chang Mo Kang
发明人: Dong Wook Kim , Chang Mo Kang
IPC分类号: B60R22/34
CPC分类号: B60R22/24 , B60R22/34 , B60R2022/3402
摘要: An apparatus for mounting a seat belt retractor for a vehicle is capable of promoting the ease with which a seat belt retractor is mounted on a center pillar by a worker, and minimizing an amount of movement of the seat belt refractor towards the interior of a vehicle body in the event of a broadside collision.
摘要翻译: 一种用于安装用于车辆的安全带卷收器的装置能够促进安全带卷收器由工作人员安装在中心支柱上的容易性,并且使安全带折射器朝向车辆内部的移动量最小化 身体在发生侧面碰撞时。
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公开(公告)号:US20120141488A1
公开(公告)日:2012-06-07
申请号:US13322304
申请日:2009-09-07
申请人: Kyung Sook Chung , Mi Sun Won , Ji Won Ahn , Jeong Hae Choi , Hyang Sook Yoo , Young Il Yeom , Eun Young Song , Hae Gu Lee , Jae Hun Cheong , Chang Mo Kang
发明人: Kyung Sook Chung , Mi Sun Won , Ji Won Ahn , Jeong Hae Choi , Hyang Sook Yoo , Young Il Yeom , Eun Young Song , Hae Gu Lee , Jae Hun Cheong , Chang Mo Kang
IPC分类号: A61K39/395 , G01N33/53 , G01N33/566 , G01N27/447 , A61K31/7088 , A61P35/00 , A61P35/04 , C12Q1/68 , C12Q1/02
CPC分类号: C07K14/705 , G01N33/5041
摘要: Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.
摘要翻译: 公开了新型GPCR(G蛋白偶联受体)蛋白和编码其的基因。 还提供了蛋白质和基因的使用。 特别地,考虑了新型GPCR(G蛋白偶联受体)多肽,编码它的多核苷酸,携带多核苷酸或其片段的重组载体,用该载体转化的宿主细胞,用载体感染的转基因动物。 另外,含有能够测定GPCR多核苷酸的mRNA或蛋白质的表达量的试剂,癌症诊断用试剂盒,含有该组合物的检测癌标记物的组合物,以及检测GPCR多肽的方法和 提供编码多肽的基因。 此外,用于治疗和预防癌症的组合物包含抑制GPCR多肽或编码GPCR蛋白的抗体表达的寡核苷酸以及筛选GPCR蛋白或癌症治疗剂的调节剂的方法, 提供。
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公开(公告)号:US09034327B2
公开(公告)日:2015-05-19
申请号:US13322304
申请日:2009-09-07
申请人: Kyung Sook Chung , Mi Sun Won , Ji Won Ahn , Jeong Hae Choi , Hyang Sook Yoo , Young Il Yeom , Eun Young Song , Hee Gu Lee , Jae Hun Cheong , Chang Mo Kang
发明人: Kyung Sook Chung , Mi Sun Won , Ji Won Ahn , Jeong Hae Choi , Hyang Sook Yoo , Young Il Yeom , Eun Young Song , Hee Gu Lee , Jae Hun Cheong , Chang Mo Kang
IPC分类号: G01N33/53 , C07K14/705 , G01N33/50
CPC分类号: C07K14/705 , G01N33/5041
摘要: Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.
摘要翻译: 公开了新型GPCR(G蛋白偶联受体)蛋白和编码其的基因。 还提供了蛋白质和基因的使用。 特别地,考虑了新型GPCR(G蛋白偶联受体)多肽,编码它的多核苷酸,携带多核苷酸或其片段的重组载体,用该载体转化的宿主细胞,用载体感染的转基因动物。 另外,含有能够测定GPCR多核苷酸的mRNA或蛋白质的表达量的试剂,癌症诊断用试剂盒,含有该组合物的检测癌标记物的组合物,以及检测GPCR多肽的方法和 提供编码多肽的基因。 此外,用于治疗和预防癌症的组合物包含抑制GPCR多肽或编码GPCR蛋白的抗体表达的寡核苷酸以及筛选GPCR蛋白或癌症治疗剂的调节剂的方法, 提供。
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公开(公告)号:US20090176888A1
公开(公告)日:2009-07-09
申请号:US12399384
申请日:2009-03-06
申请人: Su Jae LEE , Yun Sil LEE , Soo Kwan KIM , Kyung Joong KIM , Chul Koo CHO , Chang Mo KANG , Tae Hwan KIM , Sangwoo BAE , Moon Taek PARK , Jung A. CHOI , Min Jeong KIM , Hee Yong CHUNG , Sujong KIM , Seongnam KANG , Weon Ik CHOI , Jung A. KANG
发明人: Su Jae LEE , Yun Sil LEE , Soo Kwan KIM , Kyung Joong KIM , Chul Koo CHO , Chang Mo KANG , Tae Hwan KIM , Sangwoo BAE , Moon Taek PARK , Jung A. CHOI , Min Jeong KIM , Hee Yong CHUNG , Sujong KIM , Seongnam KANG , Weon Ik CHOI , Jung A. KANG
IPC分类号: A61K31/13
CPC分类号: A61K31/164 , A61K31/133
摘要: Provided is a composition for cancer treatment including phytosphingosine or a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译: 本发明提供包含植物鞘氨醇或其衍生物或其药学上可接受的盐作为活性成分的癌症治疗用组合物。
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