公开(公告)号：US08486905B2

公开(公告)日：2013-07-16

申请号：US12746722

申请日：2008-12-05

申请人： Misun Won ,  Kyung-Sook Chung ,  Young-Joo Kim ,  Shin-Jung Choi ,  Young Il Yeom ,  Seon-Young Kim ,  Kyung Bin Song ,  Hee Gu Lee ,  Eun Young Song ,  Young Ho Kim ,  Ho Kyung Chun ,  Chae-Ok Yun ,  Moon Hee Kim ,  Kyeong-Eun Jung ,  Sun-Jung Cho

发明人： Misun Won ,  Kyung-Sook Chung ,  Young-Joo Kim ,  Shin-Jung Choi ,  Young Il Yeom ,  Seon-Young Kim ,  Kyung Bin Song ,  Hee Gu Lee ,  Eun Young Song ,  Young Ho Kim ,  Ho Kyung Chun ,  Chae-Ok Yun ,  Moon Hee Kim ,  Kyeong-Eun Jung ,  Sun-Jung Cho

IPC分类号： C12N15/11 ,  C07H21/02

CPC分类号： G01N33/57484 ,  A61K31/7088 ,  A61K38/1709 ,  C12N15/1135 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2710/10343 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/00 ,  G01N2500/04

摘要： Provided are a composition for diagnosing cancer or screening an anticancer drug comprising an FLJ25416 gene or an antibody directed to a protein expressed from the FLJ25416 gene, a composition for treating cancer comprising an inhibitor of the gene or an inhibitor of the protein expressed from the gene and a pharmaceutically acceptable carrier, and a kit for diagnosing cancer comprising at least one of the FLJ25416 gene and the protein expressed from the FLJ25416 gene. The FLJ25416 gene is expressed at high level in specific cancer cells, and induces an increase in proliferation rate of normal cells. The expression of the gene is suppressed, which results in an inhibitory effect on cancer cell growth. Thus, the FLJ25416 gene can be used as a target gene for diagnosis or treatment of cancer.

摘要翻译： 提供了用于诊断癌症或筛选包含FLJ25416基因或针对从FLJ25416基因表达的蛋白质的抗体的抗癌药物的组合物，用于治疗癌症的组合物，其包含该基因的抑制剂或从该基因表达的蛋白质的抑制剂 和药学上可接受的载体，以及用于诊断癌症的试剂盒，其包含FLJ25416基因和从FLJ25416基因表达的蛋白质中的至少一种。 FLJ25416基因在特异性癌细胞中表达量高，诱导正常细胞增殖。 该基因的表达被抑制，这导致对癌细胞生长的抑制作用。 因此，FLJ25416基因可用作癌症诊断或治疗的靶基因。

公开(公告)号：US20120321635A1

公开(公告)日：2012-12-20

申请号：US13574055

申请日：2011-01-07

申请人： Kyung Chan Park ,  Young Il Yeom ,  Tae Woo Kim ,  Zee-Yong Park ,  Yun Kyung Kang ,  Suk-Jin Yang ,  Byung-Jung Choi ,  Dong Chul Lee ,  Hyun Ahm Shon ,  Hyang-Sook Yoo

发明人： Kyung Chan Park ,  Young Il Yeom ,  Tae Woo Kim ,  Zee-Yong Park ,  Yun Kyung Kang ,  Suk-Jin Yang ,  Byung-Jung Choi ,  Dong Chul Lee ,  Hyun Ahm Shon ,  Hyang-Sook Yoo

IPC分类号： A61K39/395 ,  A61K31/713 ,  A61K31/7088 ,  A61K38/02 ,  C07K16/18 ,  C07H21/04 ,  C07K2/00 ,  G01N33/574 ,  G01N21/64 ,  C12Q1/68 ,  G01N33/573 ,  C12Q1/02 ,  A61P35/00 ,  C07H21/02

CPC分类号： A61K31/7088 ,  A61K31/7105 ,  C12N15/113 ,  C12N2310/14

摘要： The present invention relates to a composition comprising an inhibitor of the expression or activity of SH3 domain containing ring finger 2 (SH3RF2) for preventing or treating cancers. More specifically, since the SH3RF2 protein, of which the expression level increases in various cancer tissues, binds to PAK4, which is a cancer-associated gene, to regulate an apoptosis inhibitory function of the PAK4 protein by ubiquitination activity of SH3RF2 RING domain, cancer cells, in which the expression of SH3RF2 is inhibited, sensitively respond to the induction of apoptosis to promote apoptosis and reduce in vivo tumorigenicity, such that the inhibitor of the expression or activity of SHRF2 can be useful as a composition for preventing or treating cancers.

摘要翻译： 本发明涉及包含用于预防或治疗癌症的含有SH3结构域的SH3结构域（SH3RF2）的表达或活性抑制剂的组合物。 更具体地说，由于在各种癌组织中表达水平升高的SH3RF2蛋白与作为癌相关基因的PAK4结合以通过SH3RF2 RING结构域的泛素化活性调节PAK4蛋白的凋亡抑制功能，癌症 其中SH3RF2的表达被抑制的细胞对凋亡的诱导敏感应答以促进凋亡并降低体内致瘤性，使得SHRF2的表达或活性的抑制剂可用作预防或治疗癌症的组合物。

公开(公告)号：US20110008370A1

公开(公告)日：2011-01-13

申请号：US12746722

申请日：2008-12-05

申请人： Misun Won ,  Kyung-Sook Chung ,  Young-Joo Kim ,  Shin-Jung Choi ,  Young Il Yeom ,  Seon-Young Kim ,  Kyung Bin Song ,  Hee Gu Lee ,  Eun Young Song ,  Young Ho Kim ,  Ho Kyung Chun ,  Chae-Ok Yun ,  Moon Hee Kim ,  Kyeong-Eun Jung ,  Sun-Jung Cho

发明人： Misun Won ,  Kyung-Sook Chung ,  Young-Joo Kim ,  Shin-Jung Choi ,  Young Il Yeom ,  Seon-Young Kim ,  Kyung Bin Song ,  Hee Gu Lee ,  Eun Young Song ,  Young Ho Kim ,  Ho Kyung Chun ,  Chae-Ok Yun ,  Moon Hee Kim ,  Kyeong-Eun Jung ,  Sun-Jung Cho

IPC分类号： A61K39/395 ,  C07H21/02 ,  A61K31/713 ,  C07H21/00 ,  C07K16/18 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/574 ,  A61P35/00

CPC分类号： G01N33/57484 ,  A61K31/7088 ,  A61K38/1709 ,  C12N15/1135 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2710/10343 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/00 ,  G01N2500/04

摘要： Provided are a composition for diagnosing cancer or screening an anticancer drug comprising an FLJ25416 gene or an antibody directed to a protein expressed from the FLJ25416 gene, a composition for treating cancer comprising an inhibitor of the gene or an inhibitor of the protein expressed from the gene and a pharmaceutically acceptable carrier, and a kit for diagnosing cancer comprising at least one of the FLJ25416 gene and the protein expressed from the FLJ25416 gene. The FLJ25416 gene is expressed at high level in specific cancer cells, and induces an increase in proliferation rate of normal cells. The expression of the gene is suppressed, which results in an inhibitory effect on cancer cell growth. Thus, the FLJ25416 gene can be used as a target gene for diagnosis or treatment of cancer.

摘要翻译： 提供了用于诊断癌症或筛选包含FLJ25416基因或针对由FLJ25416基因表达的蛋白质的抗体的抗癌药物的组合物，用于治疗癌症的组合物，其包含该基因的抑制剂或从该基因表达的蛋白质的抑制剂 和药学上可接受的载体，以及用于诊断癌症的试剂盒，其包含FLJ25416基因和从FLJ25416基因表达的蛋白质中的至少一种。 FLJ25416基因在特异性癌细胞中表达量高，诱导正常细胞增殖。 该基因的表达被抑制，这导致对癌细胞生长的抑制作用。 因此，FLJ25416基因可用作癌症诊断或治疗的靶基因。

公开(公告)号：US08283129B2

公开(公告)日：2012-10-09

申请号：US12744223

申请日：2007-11-23

申请人： Eun Young Song ,  Mi Young Park ,  Hyang Sin Lee ,  Hee Gu Lee ,  Jae Wha Kim ,  In Seong Choe ,  Min A Kang ,  Mi Sun Won ,  Kyung-Sook Chung ,  Young Ho Kim ,  Ho Kyung Chun ,  Young Il Yeom ,  Seon-Young Kim

发明人： Eun Young Song ,  Mi Young Park ,  Hyang Sin Lee ,  Hee Gu Lee ,  Jae Wha Kim ,  In Seong Choe ,  Min A Kang ,  Mi Sun Won ,  Kyung-Sook Chung ,  Young Ho Kim ,  Ho Kyung Chun ,  Young Il Yeom ,  Seon-Young Kim

IPC分类号： G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： Disclosed herein is a colorectal cancer marker for diagnosing colorectal cancer based on ESM-I overexpression in tissues, cells or body fluids of colorectal cancer patients. Disclosed also is the use of the colorectal cancer marker in the development of therapeutic agents for cancer and in the diagnosis and treatment of colorectal cancer.

摘要翻译： 本文公开了一种基于ESM-1在结肠直肠癌患者的组织，细胞或体液中过度表达的用于诊断结肠直肠癌的结肠直肠癌标志物。 还公开了结肠直肠癌标志物在癌症治疗剂的开发和结肠直肠癌的诊断和治疗中的应用。

公开(公告)号：US20110251097A1

公开(公告)日：2011-10-13

申请号：US13126500

申请日：2009-04-20

申请人： Eun Young Song ,  Hee Gu Lee ,  Young Il Yeom ,  Jae Wha Kim ,  Na Young Ji ,  Kyung-Sook Chung ,  Misun Won ,  Seon-Young Kim ,  Joo Heon Kim ,  Young Ho Kim ,  Ho Kyung Chun

发明人： Eun Young Song ,  Hee Gu Lee ,  Young Il Yeom ,  Jae Wha Kim ,  Na Young Ji ,  Kyung-Sook Chung ,  Misun Won ,  Seon-Young Kim ,  Joo Heon Kim ,  Young Ho Kim ,  Ho Kyung Chun

IPC分类号： C40B30/04 ,  G01N33/53 ,  G01N33/566 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： The present invention relates to a composition for diagnosing colon cancer. The composition comprises at least one marker for measuring an mRNA or protein expression level of at least one gene specific for colon cancer. It can screen the genes which are overexpressed specifically only in colon cancer tissues or blood. The present invention can quantitatively analyze both the mRNA expression levels of the genes and the expression levels of the proteins encoded by the gene at the same time, thereby diagnosing colon caner of an early stage with a high level of reliability.

摘要翻译： 本发明涉及用于诊断结肠癌的组合物。 组合物包含至少一种用于测量至少一种对结肠癌特异性基因的mRNA或蛋白质表达水平的标记物。 它可以筛选出仅在结肠癌组织或血液中过度表达的基因。 本发明可以同时定量分析基因的mRNA表达水平和基因编码的蛋白质的表达水平，从而以高可靠性诊断早期的结肠癌。

公开(公告)号：US09075066B2

公开(公告)日：2015-07-07

申请号：US12679879

申请日：2009-04-21

申请人： Hee Gu Lee ,  Eun Young Song ,  Min Ah Kang ,  Jong Tae Kim ,  Jae Wha Kim ,  Young Il Yeom ,  Seon Young Kim ,  Kyung Chan Park

发明人： Hee Gu Lee ,  Eun Young Song ,  Min Ah Kang ,  Jong Tae Kim ,  Jae Wha Kim ,  Young Il Yeom ,  Seon Young Kim ,  Kyung Chan Park

IPC分类号： G01N33/53 ,  G01N33/574 ,  C12Q1/68

CPC分类号： G01N33/57446 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/04

摘要： The present invention relates to a biomarker for gastric cancer, CST1 (cysteine proteinase inhibitor, type 2 family), DCC1 (Defective in sister chromatid cohesion homolog 1), IFITM1 (interferon induced transmembrane protein 1) or MELK (maternal embryonic leucine zipper kinase). More particularly, the present invention relates to a diagnostic composition for gastric cancer comprising an agent measuring the expression level of CST1, DCC1, IFITM1 or MELK, a kit comprising the composition, a method for detecting the marker, and a method for screening a therapeutic agent for gastric cancer using the marker.

摘要翻译： 本发明涉及胃癌生物标志物，CST1（半胱氨酸蛋白酶抑制剂，2型家族），DCC1（姐妹染色单体内聚同系物1缺陷），IFITM1（干扰素诱导的跨膜蛋白1）或MELK（母体白蛋白亮氨酸拉链激酶） 。 更具体地，本发明涉及用于胃癌的诊断组合物，其包含测量CST1，DCC1，IFITM1或MELK的表达水平的试剂，包含该组合物的试剂盒，用于检测标记物的方法和用于筛选治疗 使用标记的胃癌药物。

公开(公告)号：US08846630B2

公开(公告)日：2014-09-30

申请号：US13512583

申请日：2010-11-01

申请人： Misun Won ,  Kyung-Sook Chung ,  Young Joo Kim ,  Hye Kyung Hong ,  Young Il Yeom ,  Chae Ok Yun ,  Yu-Kyoung Oh ,  Kyung Bin Song ,  Hee Gu Lee ,  Young Ho Kim ,  Moon Hee Kim ,  Kyeong-Eun Jung ,  Seok Hoon Song

发明人： Misun Won ,  Kyung-Sook Chung ,  Young Joo Kim ,  Hye Kyung Hong ,  Young Il Yeom ,  Chae Ok Yun ,  Yu-Kyoung Oh ,  Kyung Bin Song ,  Hee Gu Lee ,  Eun Young Song ,  Young Ho Kim ,  Moon Hee Kim ,  Kyeong-Eun Jung

IPC分类号： C12N15/11 ,  C07H21/04 ,  A61K31/711 ,  A61K31/713 ,  A61K31/7105

CPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  C12N2310/531

摘要： The present invention provides a pharmaceutical composition for treating cancer, comprising at least one selected from deoxyribonucleic acids (DNA) for encoding small interfering RNA (siRNA) which complementarily binds to the base sequence of the transcript (mRNA transcript) of the FLJ25416 gene, represented by sequence number 3, sequence number 5, and sequence number 7 to inhibit the intracellular expression of the FLJ25416 gene, antisense RNA which inhibits expression of the FLJ25416 gene, and short hairpin RNA (shRNA) which inhibits expression of the FLJ25416 gene. As the siRNA, which is complementary to the base sequence of the transcript (mRNA transcript) of the FLJ25416 gene, the antisense RNA, and the shRNA, according to the present invention, inhibit expression of the FLJ25416 gene which is known to be expressed in cancer cells, and thus kill cancer cells, the composition of the present invention can be used as a novel anti-cancer agent.

摘要翻译： 本发明提供了一种用于治疗癌症的药物组合物，其包含选自用于编码与FLJ25416基因的转录物（mRNA转录物）的碱基序列互补结合的小干扰RNA（siRNA）的脱氧核糖核酸（DNA）中的至少一种，代表 通过序列号3，序列号5和序列号7来抑制FLJ25416基因的细胞内表达，抑制FLJ25416基因表达的反义RNA和抑制FLJ25416基因表达的短发夹RNA（shRNA）。 作为与根据本发明的FLJ25416基因，反义RNA和shRNA的转录物（mRNA转录物）的碱基序列互补的siRNA抑制FLJ25416基因的表达，已知其表达于 癌细胞，因此杀死癌细胞，本发明的组合物可以用作新的抗癌剂。

公开(公告)号：US20130028957A1

公开(公告)日：2013-01-31

申请号：US13512583

申请日：2010-11-01

申请人： Misun Won ,  Kyung-Sook Chung ,  Young Joo Kim ,  Hye Kyung Hong ,  Young Il Yeom ,  Chae Ok Yun ,  Yu-Kyoung Oh ,  Kyung Bin Song ,  Hee Gu Lee ,  Young Ho Kim ,  Moon Hee Kim ,  Kyeong-Eun Jung ,  Seok Hoon Song

发明人： Misun Won ,  Kyung-Sook Chung ,  Young Joo Kim ,  Hye Kyung Hong ,  Young Il Yeom ,  Chae Ok Yun ,  Yu-Kyoung Oh ,  Kyung Bin Song ,  Hee Gu Lee ,  Eun Young Song ,  Young Ho Kim ,  Moon Hee Kim ,  Kyeong-Eun Jung

IPC分类号： A61K31/7105 ,  C07H21/04 ,  A61P35/00 ,  A61K31/711 ,  A61K9/127 ,  C07H21/02 ,  A61K31/713

CPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  C12N2310/531

摘要： The present invention provides a pharmaceutical composition for treating cancer, comprising at least one selected from deoxyribonucleic acids (DNA) for encoding small interfering RNA (siRNA) which complementarily binds to the base sequence of the transcript (mRNA transcript) of the FLJ25416 gene, represented by sequence number 3, sequence number 5, and sequence number 7 to inhibit the intracellular expression of the FLJ25416 gene, antisense RNA which inhibits expression of the FLJ25416 gene, and short hairpin RNA (shRNA) which inhibits expression of the FLJ25416 gene. As the siRNA, which is complementary to the base sequence of the transcript (mRNA transcript) of the FLJ25416 gene, the antisense RNA, and the shRNA, according to the present invention, inhibit expression of the FLJ25416 gene which is known to be expressed in cancer cells, and thus kill cancer cells, the composition of the present invention can be used as a novel anti-cancer agent.

摘要翻译： 本发明提供了一种用于治疗癌症的药物组合物，其包含选自用于编码与FLJ25416基因的转录物（mRNA转录物）的碱基序列互补结合的小干扰RNA（siRNA）的脱氧核糖核酸（DNA）中的至少一种，代表 通过序列号3，序列号5和序列号7来抑制FLJ25416基因的细胞内表达，抑制FLJ25416基因表达的反义RNA和抑制FLJ25416基因表达的短发夹RNA（shRNA）。 作为与根据本发明的FLJ25416基因，反义RNA和shRNA的转录物（mRNA转录物）的碱基序列互补的siRNA抑制FLJ25416基因的表达，已知其表达于 癌细胞，因此杀死癌细胞，本发明的组合物可用作新的抗癌剂。

公开(公告)号：US20120141488A1

公开(公告)日：2012-06-07

申请号：US13322304

申请日：2009-09-07

申请人： Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hae Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

发明人： Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hae Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

IPC分类号： A61K39/395 ,  G01N33/53 ,  G01N33/566 ,  G01N27/447 ,  A61K31/7088 ,  A61P35/00 ,  A61P35/04 ,  C12Q1/68 ,  C12Q1/02

CPC分类号： C07K14/705 ,  G01N33/5041

摘要： Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.

摘要翻译： 公开了新型GPCR（G蛋白偶联受体）蛋白和编码其的基因。 还提供了蛋白质和基因的使用。 特别地，考虑了新型GPCR（G蛋白偶联受体）多肽，编码它的多核苷酸，携带多核苷酸或其片段的重组载体，用该载体转化的宿主细胞，用载体感染的转基因动物。 另外，含有能够测定GPCR多核苷酸的mRNA或蛋白质的表达量的试剂，癌症诊断用试剂盒，含有该组合物的检测癌标记物的组合物，以及检测GPCR多肽的方法和 提供编码多肽的基因。 此外，用于治疗和预防癌症的组合物包含抑制GPCR多肽或编码GPCR蛋白的抗体表达的寡核苷酸以及筛选GPCR蛋白或癌症治疗剂的调节剂的方法， 提供。

公开(公告)号：US20100248244A1

公开(公告)日：2010-09-30

申请号：US12744223

申请日：2007-11-23

申请人： Eun Young Song ,  Mi Young Park ,  Hyang Sin Lee ,  Hee Gu Lee ,  Jae Wha Kim ,  In Seong Choe ,  Min A. Kang ,  Mi Sun Won ,  Kyung Sook Chung ,  Young Ho Kim ,  Ho Kyung Chun ,  Young Il Yeom ,  Seon-Young Kim

发明人： Eun Young Song ,  Mi Young Park ,  Hyang Sin Lee ,  Hee Gu Lee ,  Jae Wha Kim ,  In Seong Choe ,  Min A. Kang ,  Mi Sun Won ,  Kyung Sook Chung ,  Young Ho Kim ,  Ho Kyung Chun ,  Young Il Yeom ,  Seon-Young Kim

IPC分类号： C12Q1/68 ,  C07H21/00 ,  C07K16/18 ,  G01N33/48 ,  G01N33/53 ,  C07H21/02

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： Disclosed herein is a colorectal cancer marker for diagnosing colorectal cancer based on ESM-I overexpression in tissues, cells or body fluids of colorectal cancer patients. Disclosed also is the use of the colorectal cancer marker in the development of therapeutic agents for cancer and in the diagnosis and treatment of colorectal cancer.

摘要翻译： 本文公开了一种基于ESM-1在结肠直肠癌患者的组织，细胞或体液中过度表达的用于诊断结肠直肠癌的结肠直肠癌标志物。 还公开了结肠直肠癌标志物在癌症治疗剂的开发和结肠直肠癌的诊断和治疗中的应用。