摘要:
The invention provides 1,3,4 substituted and bicyclic derivatives of 2-azetidinones and processes therefor. These compounds are valuable intermediates useful in the preparation of 1-carba(dethia)cephalosporin antibiotics.
摘要:
Disclosed is a process using hydrolysis and hydrogenation for converting enamino .beta.-lactams to their saturated alkyl ester acid salts, key intermediates to 1-carbacephalosporins. Also disclosed are intermediates resulting from the process.
摘要:
A bicycle carrier has a body member which is tubular in shape and size to have a telescoped connected fit in a tubular vehicle hitch member. A pivot support is provided at a rearward portion of the body member and pivotally supports an upright bicycle support post. Pivot support for the post is between an upright bicycle loaded position and a rearward tilted bicycle loading and unloading position that allows a tailgate for a rear door of a vehicle to be opened. Cooperating cam and a cam follower is connected between the upright support post and are driven by a turnbuckle assembly to provide a firm compressive contact between the body member and a vehicle hitch member when the bicycle support post is pivoted to its upright position whereby to provide a tight rattle-free support of the upright bicycle support post on the pivot. The cam and cam follower can also be tightened to the extent to provide a theft-proof connection. A rear extension may be provided on the body member that includes a hitch for pulling a trailer or the like behind the carrier.
摘要:
This invention provides certain sulfonamide derivatives, their pharmaceutical formulations, and their use in the treatment of susceptible neoplasms in mammals.
摘要:
The present invention provides a process for selectively alkylating pyrazoles comprising reacting a 3(5)-cyano-1H-pyrazole-4-carboxylic acid ester with a C.sub.4 -C.sub.8 alkene, or a C.sub.5 -C.sub.6 cycloalkene substituted at the 1-position with a C.sub.1 -C.sub.4 alkyl group, and a strong acid in a solvent which contains a strong electron withdrawing group. Also provided are new 3(5)-cyano-1H-pyrazole-4-carboxylic acid ester useful as starting materials in the process of the invention.
摘要:
Disclosed is a process using hydrolysis and hydrogenation for converting enamino .beta.-lactams to their saturated alkyl ester acid salts, key intermediates to 1-carbacephalosporins. Also disclosed are intermediates resulting from the process.