公开(公告)号：US06911027B1

公开(公告)日：2005-06-28

申请号：US09302055

申请日：1999-04-29

Applicant: Stuart D. Edwards ,  James A. Filice ,  Benjamin T. Nordell ,  Brian O. Armijo

Inventor： Stuart D. Edwards ,  James A. Filice ,  Benjamin T. Nordell ,  Brian O. Armijo

IPC: A61B17/24 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18

CPC classification number: A61B18/1477 ,  A61B2018/00755 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/1475

Abstract: A device for the ablation of tissue for use with the fingers of a human hand and a radio frequency power supply and controller providing a source of radio frequency energy and controls for controlling the application of radio frequency energy to the device comprising a handle sized so that is adapted to be grasped and supported by the human hand and having proximal and distal extremities. A single conductive needle formed of a conducting material is disposed in the distal extremity of the handle. An edge card is mounted in the handle and has edge mounted contacts with circuitry connected thereto. An edge mount board connector is mounted in the handle and is removably secured to the edge mounted contacts of the edge card. A cable is connected to the edge mount connector and extends from the proximal extremity of the handle and is adapted to be coupled to the radiofrequency power supply and controller. A second printed circuit board is mounted in the handle in a spaced-apart position from the edge card. A flex cable having conductive leads carried thereby extends between the edge card and the printed circuit board and is physically and electrically connected to the edge card. The proximal extremity of the needle is secured to the printed circuit board and makes electrical connections therewith.

Abstract translation: 用于消除用于人类手指的组织的装置以及提供射频能量源的控制器和控制器，所述控制器控制射频能量对装置的应用，所述手柄的尺寸使得 适于被人的手抓住并支撑，具有近端和远端。 由导电材料形成的单个导电针设置在手柄的远端。 边缘卡安装在手柄中，并且具有与其连接的电路的边缘安装的触点。 边缘安装板连接器安装在手柄中，并可拆卸地固定到边缘卡的边缘安装的触点上。 电缆连接到边缘安装连接器并从手柄的近端延伸并适于耦合到射频电源和控制器。 第二印刷电路板以与边缘卡片隔开的位置安装在手柄中。 由此承载的具有导电引线的柔性电缆在边缘卡和印刷电路板之间延伸并且物理地和电连接到边缘卡。 针的近端被固定到印刷电路板并与其电连接。

公开(公告)号：US6102907A

公开(公告)日：2000-08-15

申请号：US912273

申请日：1997-08-15

Applicant: Rick T. Smethers ,  James A. Filice ,  Kirti P. Kamdar ,  Peter H. Muller

Inventor： Rick T. Smethers ,  James A. Filice ,  Kirti P. Kamdar ,  Peter H. Muller

IPC: A61B17/24 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18

CPC classification number: A61B18/1477 ,  A61B2018/00755 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/1475

Abstract: A device for the ablation of tissue for use with the human hand and a radio frequency power supply and controller providing a source of radio frequency energy and a control for controlling the application of radio frequency energy to the device. The device includes a handle sized so that is adapted to be grasped by the human hand and has proximal and distal extremities. A needle formed of a conducting material has proximal and distal extremities. The proximal extremity of the needle is mounted on the distal extremity of the handle so that it is insulated from the handle. Conductors are carried by the handle and are connected to the needle and extend from the handle and are coupled to the radio frequency power supply and controller for supplying radio frequency energy to the needle. A temperature sensor is carried by the handle and is adapted to be coupled to the radio frequency power supply and controller for sensing the application of radio frequency energy to the tissue for controlling the application of radio frequency energy to the needle.

Abstract translation: 用于消除用于人手的组织的装置和提供射频能量源的射频电源和控制器以及用于控制将射频能量应用于该装置的控制。 该装置包括尺寸适于被人的手抓住并具有近端和远端的手柄。 由导电材料形成的针头具有近端和远端。 针的近端被安装在手柄的远端上，使得其与手柄绝缘。 导体由手柄承载并连接到针上并从手柄延伸并且耦合到射频电源和控制器以向针提供射频能量。 温度传感器由手柄承载，并且适于耦合到射频电源和控制器，用于感测向组织施加射频能量，以控制向针施加射频能量。

公开(公告)号：US20120239007A1

公开(公告)日：2012-09-20

申请号：US13355217

申请日：2012-01-20

Applicant: Edward M. Gillis ,  Barbara J. F. Laidlaw ,  John Culwell ,  James A. Filice ,  Peter Wickman ,  Andrew J. Poutiatine ,  John S. Dinka ,  Randolph M. Johnson ,  Felix Theeuwes

Inventor： Edward M. Gillis ,  Barbara J. F. Laidlaw ,  John Culwell ,  James A. Filice ,  Peter Wickman ,  Andrew J. Poutiatine ,  John S. Dinka ,  Randolph M. Johnson ,  Felix Theeuwes

IPC: A61M5/168

CPC classification number: A61F2/02 ,  A61F2250/0067 ,  A61K9/0004 ,  A61K9/0024 ,  A61K31/4468 ,  A61K31/4535 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61M5/141 ,  A61M5/14276 ,  A61M5/1452 ,  A61M5/168 ,  A61M5/16804 ,  A61M5/16881 ,  A61M31/002 ,  A61M2005/14264 ,  Y02A50/401

Abstract: The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

Abstract translation: 本发明的特征在于用于治疗疼痛的装置和方法。 药物递送装置是适于整个植入受试者的药物递送系统，并通过在持续的时间段内输送芬太尼或芬太尼（例如舒芬太尼）来提供疼痛缓解（例如，至少3天或更多 3天）。 该装置包括限定容纳药物制剂的储存器的壳体，可操作地连接到壳体的泵，以促进药物从储存器移出并离开装置;以及热膨胀元件，其限定流动通路，该热膨胀元件包括 热膨胀通道，以适应储层中配方的热膨胀。 该装置还可以包括位于流动通道内的阀，以便在使用之前防止药物从储存器中移动。

公开(公告)号：US07648496B2

公开(公告)日：2010-01-19

申请号：US11444934

申请日：2006-05-31

Applicant: Edward M. Gillis ,  Andrew L. Poutiatine ,  James A. Filice ,  Peter Wickman ,  John Culwell ,  John S. Dinka

Inventor： Edward M. Gillis ,  Andrew L. Poutiatine ,  James A. Filice ,  Peter Wickman ,  John Culwell ,  John S. Dinka

IPC: A61K9/22

CPC classification number: A61K9/0024 ,  A61F2/02 ,  A61F2250/0067 ,  A61K9/0004 ,  A61M5/141 ,  A61M5/14276 ,  A61M5/1452 ,  A61M5/16881 ,  A61M2005/14264

Abstract: Implantable delivery devices (1) for accurately controlling release of an agent therefrom and for preventing release of the agent during storage, prior to use. The devices include a reservoir (3) for storing the agent, a driving means for driving the agent from the reservoir (3) and a valving and control mechanism (10) which is positively actuatable between a closed configuration and an open configuration.

Abstract translation: 植入式输送装置（1），用于从使用前准确控制试剂的释放并防止储存期间试剂的释放。 这些装置包括用于储存试剂的储存器（3），用于从储存器（3）驱动试剂的驱动装置和在关闭构型和打开构型之间可靠地致动的阀门和控制机构（10）。

公开(公告)号：US06835194B2

公开(公告)日：2004-12-28

申请号：US10188325

申请日：2002-06-27

Applicant: Randolph Mellus Johnson ,  Felix Theeuwes ,  Edward M. Gillis ,  Dana Litmanovitz ,  Barbara Laidlaw ,  James Brown ,  John Culwell ,  James A. Filice ,  Peter Wickman ,  Su-Il Yum ,  Andrew Poutiatine ,  John Dinka

Inventor： Randolph Mellus Johnson ,  Felix Theeuwes ,  Edward M. Gillis ,  Dana Litmanovitz ,  Barbara Laidlaw ,  James Brown ,  John Culwell ,  James A. Filice ,  Peter Wickman ,  Su-Il Yum ,  Andrew Poutiatine ,  John Dinka

IPC: A61K922

CPC classification number: A61F2/02 ,  A61F2250/0067 ,  A61K9/0004 ,  A61K9/0024 ,  A61K31/4468 ,  A61K31/4535 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61M5/141 ,  A61M5/14276 ,  A61M5/1452 ,  A61M5/168 ,  A61M5/16804 ,  A61M5/16881 ,  A61M31/002 ,  A61M2005/14264

Abstract: The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

Abstract translation: 本发明的特征在于用于治疗疼痛的装置和方法。 药物递送装置是适于整个植入受试者的药物递送系统，并通过在持续的时间段内输送芬太尼或芬太尼（例如舒芬太尼）来提供疼痛缓解（例如，至少3天或更多 3天）。 该装置包括限定容纳药物制剂的储存器的壳体，可操作地连接到壳体的泵，以促进药物从储存器移出并离开装置;以及热膨胀元件，其限定流动通路，该热膨胀元件包括 热膨胀通道，以适应储层中配方的热膨胀。 该装置还可以包括位于流动通道内的阀，以便在使用之前防止药物从储存器中移动。

公开(公告)号：US06371926B1

公开(公告)日：2002-04-16

申请号：US09574607

申请日：2000-05-17

Applicant: Ted S. Thorson ,  James A. Filice

Inventor： Ted S. Thorson ,  James A. Filice

IPC: A61B500

CPC classification number: A61B18/14 ,  A61B2017/00092 ,  A61B2018/00821

Abstract: Systems and methods are described for a wire based temperature sensing electrode for surgical procedures. A temperature sensing energy delivery device includes an elongated member having a groove formed in at least portion of the elongated member; and a first temperature sensor mechanically connected to the elongated member, the first temperature sensor including a first temperature sensor lead that is routed along the groove. The systems and methods provide advantages in that the wire based temperature sensing electrode for surgical procedures can simultaneously accommodate a temperature sensor and associated leads, exhibit sufficient strength without bulk, and be provided at lower cost.

Abstract translation: 针对用于外科手术的线基温度感测电极描述了系统和方法。 温度感测能量输送装置包括细长构件，其具有形成在细长构件的至少一部分中的凹槽; 以及与所述细长构件机械连接的第一温度传感器，所述第一温度传感器包括沿着所述凹槽布线的第一温度传感器引线。 该系统和方法提供的优点在于，用于外科手术的基于线的温度感测电极可以同时容纳温度传感器和相关联的引线，在没有体积的情况下表现出足够的强度，并且以较低的成本提供。

公开(公告)号：US6131579A

公开(公告)日：2000-10-17

申请号：US64023

申请日：1998-04-21

Applicant: Ted S. Thorson ,  James A. Filice

Inventor： Ted S. Thorson ,  James A. Filice

IPC: A61B5/01 ,  A61B17/00 ,  A61B18/14 ,  A61B19/00

CPC classification number: A61B18/14 ,  A61B2017/00092 ,  A61B2018/00821

Abstract: Systems and methods are described for a wire based temperature sensing electrode for surgical procedures. A temperature sensing energy delivery device includes an elongated member having a groove formed in at least portion of the elongated member; and a first temperature sensor mechanically connected to the elongated member, the first temperature sensor including a first temperature sensor lead that is routed along the groove. The systems and methods provide advantages in that the wire based temperature sensing electrode for surgical procedures can simultaneously accommodate a temperature sensor and associated leads, exhibit sufficient strength without bulk, and be provided at lower cost.

Abstract translation: 针对用于外科手术的线基温度感测电极描述了系统和方法。 温度感测能量输送装置包括细长构件，其具有形成在细长构件的至少一部分中的凹槽; 以及与所述细长构件机械连接的第一温度传感器，所述第一温度传感器包括沿着所述凹槽布线的第一温度传感器引线。 该系统和方法提供的优点在于，用于外科手术的基于线的温度感测电极可以同时容纳温度传感器和相关联的引线，在没有体积的情况下表现出足够的强度，并且以较低的成本提供。