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1.发明授权Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners 失效通过输送芬太尼和芬太尼同系物治疗疼痛的植入式装置和方法公开(公告)号：US06835194B2
公开(公告)日：2004-12-28
申请号：US10188325
申请日：2002-06-27
申请人： Randolph Mellus Johnson , Felix Theeuwes , Edward M. Gillis , Dana Litmanovitz , Barbara Laidlaw , James Brown , John Culwell , James A. Filice , Peter Wickman , Su-Il Yum , Andrew Poutiatine , John Dinka
发明人： Randolph Mellus Johnson , Felix Theeuwes , Edward M. Gillis , Dana Litmanovitz , Barbara Laidlaw , James Brown , John Culwell , James A. Filice , Peter Wickman , Su-Il Yum , Andrew Poutiatine , John Dinka
IPC分类号： A61K922
CPC分类号： A61F2/02 , A61F2250/0067 , A61K9/0004 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/141 , A61M5/14276 , A61M5/1452 , A61M5/168 , A61M5/16804 , A61M5/16881 , A61M31/002 , A61M2005/14264
摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.
摘要翻译： 本发明的特征在于用于治疗疼痛的装置和方法。 药物递送装置是适于整个植入受试者的药物递送系统，并通过在持续的时间段内输送芬太尼或芬太尼（例如舒芬太尼）来提供疼痛缓解（例如，至少3天或更多 3天）。 该装置包括限定容纳药物制剂的储存器的壳体，可操作地连接到壳体的泵，以促进药物从储存器移出并离开装置;以及热膨胀元件，其限定流动通路，该热膨胀元件包括 热膨胀通道，以适应储层中配方的热膨胀。 该装置还可以包括位于流动通道内的阀，以便在使用之前防止药物从储存器中移动。
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2.发明申请公开(公告)号：US20050070883A1
公开(公告)日：2005-03-31
申请号：US10433196
申请日：2001-11-21
申请人： James Brown , John Culwell , James Filice , Edward Gillis , Felix Theeuwes , Peter Wickman , Su Il Yum
发明人： James Brown , John Culwell , James Filice , Edward Gillis , Felix Theeuwes , Peter Wickman , Su Il Yum
CPC分类号： A61M5/14276 , A61K9/0004 , A61M5/168 , A61M5/16804 , A61M5/36 , A61M31/002 , A61M2205/0294
摘要： The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.
摘要翻译： 本发明的特征在于一种用于药物递送装置的塞子，其中塞子限定扩张控制通道，其适应制剂在药物递送装置的储存器中的热膨胀和出口通道。 在一个实施例中，塞子包括内塞构件和外塞构件，这些构件限定了膨胀控制通道，以便于捕获的空气的释放和适应制剂从密封的药物储存器的热膨胀。 插头进一步限定出口通道，并且可以任选地进一步包括刚刚在输送出口之前或两者位于流动通道内的玻璃料。
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公开(公告)号：US09220881B2
公开(公告)日：2015-12-29
申请号：US13601755
申请日：2012-08-31
申请人： Jack W. Kaufman , Janet P. Kaufman , James Brown
发明人： Jack W. Kaufman , James Brown
CPC分类号： A61M35/006 , A45D34/04 , A45D2200/1018 , A61L2/00 , A61L2/18 , A61M35/003 , A61M2205/273 , B43M11/06
摘要： A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. The applicator may be applicable for a medical purpose. When the frangible applicator tip is broken, the fluid flows from the source to the absorbent member, spread on a surface. The frangible applicator tip may comprise a support element permanently connected to the fluid source, a relatively rigid tongue element, and a frangible region there between. The tongue element may comprise ribs for reinforcing the tongue element. The applicator tip may comprise a semi-permeable or non-permeable cover to control the speed and direction of the dispersion of the fluid.
摘要翻译： 一种手持式分配器，其包括流体源，连接到流体源的易碎施用器尖端以及附接到易碎施用器尖端的吸收构件。 施用器可以适用于医疗目的。 当易碎的施用器尖端被破坏时，流体从源流向吸收构件，扩散在表面上。 易碎的施用器尖端可以包括永久地连接到流体源的支撑元件，相对刚性的舌元件以及其间的易碎区域。 舌元件可以包括用于加强舌元件的肋。 施用器尖端可以包括半渗透性或不可渗透的覆盖物，以控制流体的分散体的速度和方向。
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公开(公告)号：US09107491B2
公开(公告)日：2015-08-18
申请号：US13386944
申请日：2010-07-23
申请人： James Brown , Dennis K. Ontumi , Richard Robinson
发明人： James Brown , Dennis K. Ontumi , Richard Robinson
CPC分类号： A46B11/0003 , A46B11/001 , A46B11/0041 , A46B11/0065 , A46B15/0091 , A46B15/0093 , A46B2200/1066 , A61K6/0008 , A61K8/25 , A61K8/375 , A61K2800/28 , A61K2800/412 , A61Q11/00
摘要： A dentifrice composition containing minor amounts of relatively small particle size high cleaning abrasives, without oral care actives. The dentifrice may be encapsulated and optionally, positioned on the head of a toothbrush. Use of the dentifrice provides a small amount of high cleaning abrasive to the teeth, and has stain removal efficacy. In one aspect, a dentifrice composition comprising an orally acceptable carrier and 1 to 10 wt % abrasive, such that the total amount of abrasive delivered per application is 2 mg to 8 mg, the abrasive having a weight mean particle size in the range of 3 to 7 μm, with at least 90% of the particles by weight having a size below 16 μm, and wherein the composition does not contain an oral care active.
摘要翻译： 洁牙剂组合物含有少量相对较小粒径的高清洁磨料，无需口腔护理活性物质。 洁齿剂可以被封装并任选地定位在牙刷的头部上。 洁齿剂的使用为牙齿提供少量高清洁磨料，并具有去污效果。 一方面，一种洁齿剂组合物，其包含口服可接受的载体和1至10重量％的研磨剂，使得每次施用所输送的磨料的总量为2mg至8mg，所述研磨剂的重均粒径在3 至7μm，其中至少90重量％的颗粒具有小于16μm的尺寸，并且其中所述组合物不含有口腔护理活性物质。
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公开(公告)号：USD718131S1
公开(公告)日：2014-11-25
申请号：US29471427
申请日：2013-10-31
申请人： James Brown
设计人： James Brown
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6.发明授权Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use 有权螺四环环化合物作为β-分泌酶调节剂和使用方法公开(公告)号：US08883782B2
公开(公告)日：2014-11-11
申请号：US13047734
申请日：2011-03-14
申请人： Yuan Cheng , Ryan White , Albert Amegadzie , James Brown , Alan C. Cheng , Erin F. Dimauro , Thomas Dineen , Oleg Epstein , Vijay Keshav Gore , Jason Brooks Human , Ted Judd , Charles Kreiman , Qingyian Liu , Patricia Lopez , Vu Van Ma , Isaac Marx , Ana Minatti , Hanh Nho Nguyen , Nick A. Paras , Vinod F. Patel , Wenyuan Qian , Matthew Weiss , Qiufen Xue , Xiao Mei Zheng , Wenge Zhong
发明人： Yuan Cheng , Ryan White , Albert Amegadzie , James Brown , Alan C. Cheng , Erin F. Dimauro , Thomas Dineen , Oleg Epstein , Vijay Keshav Gore , Jason Brooks Human , Ted Judd , Charles Kreiman , Qingyian Liu , Patricia Lopez , Vu Van Ma , Isaac Marx , Ana Minatti , Hanh Nho Nguyen , Nick A. Paras , Vinod F. Patel , Wenyuan Qian , Matthew Weiss , Qiufen Xue , Xiao Mei Zheng , Wenge Zhong
IPC分类号： A61K31/42 , A61K31/422 , A61K31/506 , A61K31/4439 , A61K31/5377 , C07D221/20 , C07D235/02 , C07D263/08 , C07D295/135 , C07D491/10 , C07D498/10
CPC分类号： C07D491/10 , A61K31/42 , A61K31/422 , A61K31/4439 , A61K31/506 , A61K31/5377 , C07D221/20 , C07D235/02 , C07D263/08 , C07D295/135 , C07D498/10 , C07D498/20 , C07D513/10 , C09B11/28
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X and Y of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译： 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默氏病（AD））和其它相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中式I中的A1，A2，A3，A4，A5，A6，R2，R7，X和Y如本文所定义。 本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这种病症包括例如阿尔茨海默氏病，认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。
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公开(公告)号：US08664302B2
公开(公告)日：2014-03-04
申请号：US12242579
申请日：2008-09-30
申请人： Susanna Ho , Daryl MacLeod , James Brown , Lloyd Gee , Ludo Zanzotto
发明人： Susanna Ho , Daryl MacLeod , James Brown , Lloyd Gee , Ludo Zanzotto
CPC分类号： C08J3/226 , C08J2495/00 , C08L95/00
摘要： A process of preparing a polymer modified asphalt (PMA) comprising mixing a predetermined amount of a polymer-asphalt master batch with a predetermined amount of an asphalt-cross linking agent blend. The polymer-asphalt master batch comprises at least one polymer and a first asphalt. The asphalt-cross linking agent blend comprises a second asphalt and at least one cross linking agent. A predetermined amount of the polymer-asphalt master batch is blended with a predetermined amount of the asphalt-cross linking agent blend to form a PMA blend. Mixing of the PMA blend is performed without substantial delay following blending of the polymer-asphalt master batch with the asphalt-cross linking agent blend.
摘要翻译： 一种制备聚合物改性沥青（PMA）的方法，包括将预定量的聚合物 - 沥青母料与预定量的沥青交联剂混合物混合。 聚合物 - 沥青母料包含至少一种聚合物和第一沥青。 沥青交联剂混合物包含第二沥青和至少一种交联剂。 将预定量的聚合物 - 沥青母料与预定量的沥青交联剂混合物共混以形成PMA共混物。 在混合聚合物 - 沥青母料与沥青交联剂混合物之后，PMA共混物的混合在没有实质延迟的情况下进行。
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公开(公告)号：US08608397B2
公开(公告)日：2013-12-17
申请号：US13485013
申请日：2012-05-31
申请人： Jack W. Kaufman , James Brown
发明人： Jack W. Kaufman , James Brown
IPC分类号： B43K5/14
CPC分类号： A61M35/006 , A61M35/003 , A61M2210/04 , B43M11/06
摘要： A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.
摘要翻译： 一种手持式分配器，其包括流体源，连接到流体源的易碎施用器尖端以及附接到易碎施用器尖端的吸收构件。 当易碎的施用器尖端被破坏时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及它们之间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。 自适应实施例允许生成适用于特定医疗目的的设计。
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公开(公告)号：US08297478B2
公开(公告)日：2012-10-30
申请号：US12241438
申请日：2008-09-30
CPC分类号： G01F13/005 , B23K26/144 , B23K26/147 , B23K26/702
摘要： Powder feed cylinder assemblies and powder feeders are provided. A powder feed cylinder assembly includes a cylinder, a bit, and bushings. The cylinder has a main passage, a first feed channel, and a second feed channel, each feed channel at two axial locations between the cylinder's two ends. The bit extends through the main passage and has an outer surface including a helical channel formed thereon. A center bushing is disposed in the main passage between the two axial locations and has a first axially-extending passage through which the bit extends. The first end bushing is disposed in the main passage on one side of the center bushing and has a second axially-extending passage through which the bit extends. The second end bushing is disposed in the cylinder on the other side of the center bushing and has a third axially-extending passage through which the bit extends.
摘要翻译： 提供粉末进料缸组件和粉末进料器。 粉末进料缸组件包括气缸，钻头和衬套。 气缸具有主通道，第一进料通道和第二进料通道，每个进料通道在气缸两端之间的两个轴向位置。 钻头延伸穿过主通道并且具有包括形成在其上的螺旋通道的外表面。 中心衬套设置在两个轴向位置之间的主通道中，并且具有第一轴向延伸的通道，钻头通过该通道延伸。 第一端衬套设置在中间衬套的一侧的主通道中，并且具有第二轴向延伸的通道，钻头通过该通道延伸。 第二端衬套设置在中心衬套的另一侧的气缸中，并且具有第三轴向延伸的通道，钻头通过该通道延伸。
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公开(公告)号：US08186897B2
公开(公告)日：2012-05-29
申请号：US11740920
申请日：2007-04-27
申请人： Jack W. Kaufman , James Brown
发明人： Jack W. Kaufman , James Brown
IPC分类号： B43K5/14
CPC分类号： A61M35/006 , A45D34/042 , A61M35/003 , B43M11/06
摘要： A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.
摘要翻译： 一种手持式分配器，其包括流体源，连接到流体源的易碎施用器尖端以及附接到易碎施用器尖端的吸收构件。 当易碎的施用器尖端破裂时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎的施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及其间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。 自适应实施例允许生成适用于特定医疗目的的设计。
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