公开(公告)号：US06835194B2

公开(公告)日：2004-12-28

申请号：US10188325

申请日：2002-06-27

申请人： Randolph Mellus Johnson ,  Felix Theeuwes ,  Edward M. Gillis ,  Dana Litmanovitz ,  Barbara Laidlaw ,  James Brown ,  John Culwell ,  James A. Filice ,  Peter Wickman ,  Su-Il Yum ,  Andrew Poutiatine ,  John Dinka

发明人： Randolph Mellus Johnson ,  Felix Theeuwes ,  Edward M. Gillis ,  Dana Litmanovitz ,  Barbara Laidlaw ,  James Brown ,  John Culwell ,  James A. Filice ,  Peter Wickman ,  Su-Il Yum ,  Andrew Poutiatine ,  John Dinka

IPC分类号： A61K922

CPC分类号： A61F2/02 ,  A61F2250/0067 ,  A61K9/0004 ,  A61K9/0024 ,  A61K31/4468 ,  A61K31/4535 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61M5/141 ,  A61M5/14276 ,  A61M5/1452 ,  A61M5/168 ,  A61M5/16804 ,  A61M5/16881 ,  A61M31/002 ,  A61M2005/14264

摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

摘要翻译： 本发明的特征在于用于治疗疼痛的装置和方法。 药物递送装置是适于整个植入受试者的药物递送系统，并通过在持续的时间段内输送芬太尼或芬太尼（例如舒芬太尼）来提供疼痛缓解（例如，至少3天或更多 3天）。 该装置包括限定容纳药物制剂的储存器的壳体，可操作地连接到壳体的泵，以促进药物从储存器移出并离开装置;以及热膨胀元件，其限定流动通路，该热膨胀元件包括 热膨胀通道，以适应储层中配方的热膨胀。 该装置还可以包括位于流动通道内的阀，以便在使用之前防止药物从储存器中移动。

公开(公告)号：US20070014820A1

公开(公告)日：2007-01-18

申请号：US11477140

申请日：2006-06-27

申请人： Dana Litmanovitz ,  Barbara Laidlaw

发明人： Dana Litmanovitz ,  Barbara Laidlaw

IPC分类号： A61K9/00 ,  A61K31/445

CPC分类号： A61K31/4535 ,  A61K31/4468

摘要： The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in concentrations significantly in excess of conventional formulations, e.g., on the order about 2-fold to about 10,000-fold greater than conventional formulations, e.g., currently commercially available formulations. These formulations are particularly useful for long-term delivery to a subject suffering from pain. The invention further provides drug delivery devices comprising the high-concentration opioid formulations, and further provides methods of alleviating pain in a subject, comprising administering the high-concentration formulations to a subject in need thereof.

摘要翻译： 本发明提供阿片样物质如芬太尼或芬太尼同系物的高浓度制剂。 本发明的制剂包括浓度显着超过常规制剂的芬太尼或芬太尼同系物，例如比常规制剂例如目前市售的制剂大约2倍至约10,000倍。 这些制剂对于长期运送到患有疼痛的受试者是特别有用的。 本发明进一步提供了包含高浓度阿片样物质制剂的药物递送装置，并且还提供减轻受试者疼痛的方法，包括向有需要的受试者施用高浓度制剂。

公开(公告)号：US07074803B2

公开(公告)日：2006-07-11

申请号：US10220525

申请日：2001-03-02

申请人： Dana Litmanovitz ,  Barbara J. F. Laidlaw

发明人： Dana Litmanovitz ,  Barbara J. F. Laidlaw

IPC分类号： A01N43/42 ,  C07D211/36

CPC分类号： A61K31/4535 ,  A61K31/4468

摘要： The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in concentrations significantly in excess of conventional formulations, e.g., on the order about 2-fold to about 10,000-fold greater than conventional formulations, e.g., currently commercially available formulations. These formulations are particularly useful for long-term delivery to a subject suffering from pain. The invention further provides drug delivery devices comprising the high-concentration opioid formulations, and further provides methods of alleviating pain in a subject, comprising administering the high-concentration formulations to a subject in need thereof.