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公开(公告)号：US20080292638A1
公开(公告)日：2008-11-27
申请号：US12096383
申请日：2006-12-20
Applicant: Bryan Edward Jones , James D. Pancook , Scott William Rowlinson
Inventor： Bryan Edward Jones , James D. Pancook , Scott William Rowlinson
IPC: A61K39/395 , C07K16/18 , A61P31/00
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.
Abstract translation: 本发明提供了中和成熟的人TGF-β1，TGF-β2和TGF-β3的非常高亲和力的抗体或其抗原结合片段。 本发明的抗体可用于治疗哺乳动物的细胞增殖性疾病。
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Patent Agency Ranking
公开(公告)号：US20090155285A1
公开(公告)日：2009-06-18
申请号：US12366664
申请日：2009-02-06
Applicant: Bryan Edward Jones , James D. Pancook , Scott William Rowlinson
Inventor： Bryan Edward Jones , James D. Pancook , Scott William Rowlinson
IPC: A61K39/395
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.
Abstract translation: 本发明提供了中和成熟的人TGF-β1，TGF-β2和TGF-β3的非常高亲和力的抗体或其抗原结合片段。 本发明的抗体可用于治疗哺乳动物的细胞增殖性疾病。
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3.发明授权公开(公告)号：US07049121B2
公开(公告)日：2006-05-23
申请号：US10324466
申请日：2002-12-20
Applicant: Jeffry D Watkins , James D Pancook
Inventor： Jeffry D Watkins , James D Pancook
CPC classification number: C12N9/18 , A61K38/00 , C12Y301/01008 , C12Y301/01084
Abstract: The invention provides twenty-one butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
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4.发明授权Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use 失效丁酰胆碱酯酶多肽具有增加的催化效率和使用方法公开(公告)号：US06989261B2
公开(公告)日：2006-01-24
申请号：US10413432
申请日：2003-04-11
Applicant: Jeffry D. Watkins , James D. Pancook
Inventor： Jeffry D. Watkins , James D. Pancook
CPC classification number: C12N9/18 , A61K38/00 , C12Y301/01008
Abstract: The invention provides a butyrylcholinesterase variant having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acid. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition with the invention variant.
Abstract translation: 本发明提供了具有增加的可卡因水解活性的丁酰胆碱酯酶变体以及相应的编码核酸。 本发明还提供了水解可卡因类丁酰胆碱酯酶底物的方法以及用本发明变体治疗可卡因诱导病症的方法。
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公开(公告)号：US20100136021A1
公开(公告)日：2010-06-03
申请号：US12693722
申请日：2010-01-26
Applicant: Bryan Edward Jones , James D. Pancook , Scott William Rowlinson
Inventor： Bryan Edward Jones , James D. Pancook , Scott William Rowlinson
IPC: A61K39/395 , C07K16/26 , A61P9/00 , A61P29/00 , A61P35/00
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are useful for mating cell proliferative disorders in a mammal.
Abstract translation: 本发明提供了非常高亲和力的抗体或其抗原结合片段，其中和成熟的人TGF-β1，TGF-β2和TGF-β1。 本发明的抗体可用于在哺乳动物中交配细胞增殖性疾病。
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公开(公告)号：US07494651B2
公开(公告)日：2009-02-24
申请号：US12096383
申请日：2006-12-20
Applicant: Bryan Edward Jones , James D. Pancook , Scott William Rowlinson
Inventor： Bryan Edward Jones , James D. Pancook , Scott William Rowlinson
IPC: A61K39/395 , C07K16/22
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.
Abstract translation: 本发明提供了中和成熟的人TGF-β1，TGF-β2和TGF-β3的非常高亲和力的抗体或其抗原结合片段。 本发明的抗体可用于治疗哺乳动物的细胞增殖性疾病。
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