公开(公告)号：US20060122242A1

公开(公告)日：2006-06-08

申请号：US11334152

申请日：2006-01-18

Applicant: Alan Adams ,  A. Jones ,  Joel Berger ,  James Dropinski ,  Alexander Elbrecht ,  Kun Liu ,  Karen MacNaul ,  Guo-Qiang Shi ,  Derek Von Langen ,  Gaochao Zhou

Inventor： Alan Adams ,  A. Jones ,  Joel Berger ,  James Dropinski ,  Alexander Elbrecht ,  Kun Liu ,  Karen MacNaul ,  Guo-Qiang Shi ,  Derek Von Langen ,  Gaochao Zhou

IPC: A61K31/428 ,  A61K31/423 ,  A61K31/425 ,  A61K31/42

CPC classification number: C07D257/04 ,  C07C59/90 ,  C07D213/55 ,  C07D261/20 ,  C07D263/32 ,  C07D263/58 ,  C07D413/12 ,  C07D417/12

Abstract: A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.

Abstract translation: 一类2-芳氧基-2-芳基链烷酸包括作为PPARα和/或γ的有效激动剂的化合物，因此可用于治疗，控制或预防非胰岛素依赖型糖尿病（NIDDM），高血糖症，血脂异常 高脂血症，高胆固醇血症，高甘油三酯血症，动脉粥样硬化，肥胖症，血管再狭窄，炎症和其他PPARα和/或γ介导的疾病，病症和病症。

公开(公告)号：US20080039514A1

公开(公告)日：2008-02-14

申请号：US11662808

申请日：2005-09-12

Applicant: James Dropinski ,  Guo Shi ,  Yong Zhang

Inventor： James Dropinski ,  Guo Shi ,  Yong Zhang

IPC: A61K31/42 ,  A61P3/00 ,  C07D261/20

CPC classification number: C07D261/20 ,  C07D413/12

Abstract: A class of compounds having Formula I and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of developing conditions and sequelae that are associated with these diseases, such as atherosclerosis.

Abstract translation: 一类具有式I的化合物及其药学上可接受的盐可用作治疗性化合物，特别是用于治疗高脂血症，高胆固醇血症，血脂异常和其它脂质疾病，以及延迟发展或降低发展疾病和后遗症的风险， 与这些疾病有关，如动脉粥样硬化。

公开(公告)号：US20070173434A1

公开(公告)日：2007-07-26

申请号：US10586976

申请日：2005-01-18

Applicant: Guo Shi ,  Peter Meinke ,  James Dropinski ,  Yong Zhang

Inventor： Guo Shi ,  Peter Meinke ,  James Dropinski ,  Yong Zhang

IPC: A61K31/427 ,  A61K31/421 ,  A61K38/28 ,  C07D263/04 ,  C07D277/04

CPC classification number: C07D263/44 ,  A61K38/26 ,  A61K38/28 ,  C07D263/64 ,  C07D277/34 ,  A61K2300/00

Abstract: Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones of formula (I) are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Abstract translation: 式（I）的苯氧基苯基和苯氧基苄基恶唑烷-2,4-二酮和噻唑烷-2,4-二酮是PPARγ的激动剂或部分激动剂，可用于治疗和控制II型糖尿病症状的高血糖，如 以及通常与2型糖尿病相关的血脂异常，高脂血症，高胆固醇血症，高甘油三酯血症和肥胖。

公开(公告)号：US07863465B2

公开(公告)日：2011-01-04

申请号：US11727927

申请日：2007-03-29

Applicant: James M. Balkovec ,  Frances Aileen Bouffard ,  Bruno Tse ,  James Dropinski ,  Dongfang Meng ,  Mark L. Greenlee ,  Michael Peel ,  Weiming Fan ,  Ahmed Mamai ,  Hao Liu ,  Keqaing Li

Inventor： James M. Balkovec ,  Frances Aileen Bouffard ,  Bruno Tse ,  James Dropinski ,  Dongfang Meng ,  Mark L. Greenlee ,  Michael Peel ,  Weiming Fan ,  Ahmed Mamai ,  Hao Liu ,  Keqaing Li

IPC: C07D311/00 ,  C07D315/00

CPC classification number: C07J71/0005

Abstract: The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.

Abstract translation: 本发明涉及式I的新型烯虫腈衍生物及其药学上可接受的盐，它们的合成及其作为（1,3） - β-葡聚糖合酶抑制剂的用途。 本发明化合物及其药学上可接受的盐以及包含本发明化合物及其药学上可接受的盐的药物组合物可用于治疗或预防抗真菌感染和相关疾病和病症。

公开(公告)号：US20080009504A1

公开(公告)日：2008-01-10

申请号：US11727927

申请日：2007-03-29

Applicant: James Balkovec ,  Frances Bouffard ,  Bruno Tse ,  James Dropinski ,  Dongfang Meng ,  Mark Greenlee ,  Michael Peel ,  Weiming Fan ,  Ahmed Mamai ,  Hao Liu ,  Keqaing Li

Inventor： James Balkovec ,  Frances Bouffard ,  Bruno Tse ,  James Dropinski ,  Dongfang Meng ,  Mark Greenlee ,  Michael Peel ,  Weiming Fan ,  Ahmed Mamai ,  Hao Liu ,  Keqaing Li

IPC: A61K31/495 ,  A61K31/35 ,  A61K31/4196 ,  A61P31/00 ,  C07D239/02 ,  C07D277/02 ,  C07D311/02 ,  C07D295/00 ,  C07D249/08 ,  C07D207/00 ,  A61K31/496 ,  A61K31/426

CPC classification number: C07J71/0005

Abstract: The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.

Abstract translation: 本发明涉及式I的新型烯虫腈衍生物及其药学上可接受的盐，其合成及其作为（1,3）-β-D-葡聚糖合酶抑制剂的用途。 本发明化合物及其药学上可接受的盐以及包含本发明化合物及其药学上可接受的盐的药物组合物可用于治疗或预防抗真菌感染和相关疾病和病症。