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公开(公告)号：US06190368B1
公开(公告)日：2001-02-20
申请号：US09310895
申请日：1999-05-12
IPC分类号： A61M100
CPC分类号： A61M1/02 , A61B5/150038 , A61B5/150045 , A61B5/150068 , A61B5/150213 , A61B5/150221 , A61B5/150366 , A61B5/150755 , A61M2202/0462
摘要： An apparatus and method for collecting a large volume of blood from an umbilical cord in a sterile environment are shown and described. A housing having an inner region adapted to retain an umbilical cord in a desired location is provided, the housing having an opening through which the cord extends from the inner region of the housing to a region external to the housing. The cord is cut by a blade coupled to the housing, either by the motion of the blade from a first position to a second position, or by the movement of two portions of the housing from a first extended position to a second collapsed position. The newly cut end of the umbilical cord falls and hangs freely in the inner region of the housing, blood flowing from the placenta and umbilical cord via gravity into a blood collection region of the housing. The blood collection region may be flexible, and may be coupled to a conventional blood collection bag.
摘要翻译： 显示和描述了用于在无菌环境中从脐带收集大量血液的装置和方法。 提供了具有适于将脐带保持在期望位置的内部区域的壳体，所述壳体具有开口，所述绳索通过所述开口从所述壳体的内部区域延伸到所述壳体外部的区域。 绳索由联接到壳体的叶片切割，或者通过叶片从第一位置到第二位置的运动，或者通过壳体的两个部分从第一延伸位置到第二收缩位置的运动来切割。 脐带的新切割端在房屋的内部区域自由落下并悬挂，血液从胎盘和脐带通过重力流入外壳的采血区域。 采集区域可以是柔性的，并且可以联接到常规采血袋。
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公开(公告)号：US06890321B2
公开(公告)日：2005-05-10
申请号：US10644047
申请日：2003-08-19
CPC分类号： A61M25/0606
摘要： A soft over-the-needle (OTN) catheter that has been treated at a distal end to provide a higher durometer (i.e., harder) surface to facilitate insertion of the catheter into a patient is provided. The catheter preferably comprises a soft flexible tube made of polyurethane and having a hardness in the range of 50A to 90A where the treated distal end has a hardness of above 90A. The OTN catheter may also include an annular abutment shoulder formed at a distance from the distal end of the catheter. An insertion needle also comprises an abutment means, preferably a collar positioned on the exterior of the insertion needle, to abut the abutment shoulder of the catheter. Where the catheter is to be fed significantly into the vascular system, an optional metal ring may be secured within the catheter, adjacent the internal shoulder. When the needle is removed, the metal ring remains in place, permitting electromagnetic tracking of the catheter as it is fed through the vascular system. In an alternative embodiment, rather than chemically treating the distal end of a soft catheter, a discrete segment of hard tubing is press fit into the interior of the distal end of a soft catheter.
摘要翻译： 提供了一种在远端处理以提供更高硬度（即较硬））表面以便于将导管插入患者体内的柔软的超针（OTN）导管。 导管优选地包括由聚氨酯制成的柔性软管，其硬度在50A至90A的范围内，其中所治疗的远端具有高于90A的硬度。 OTN导管还可以包括在距离导管的远端一定距离处形成的环形邻接肩部。 插入针还包括邻接装置，优选地位于插入针的外部上的套环，以邻接导管的邻接肩部。 在导管被显着地进入血管系统的地方，可选择的金属环可以固定在导管内，靠近内肩部。 当针被移除时，金属环保持在适当的位置，允许在通过血管系统进给时导管的电磁跟踪。 在替代实施例中，不是化学地处理软导管的远端，而是将一个离散的硬管段压配合到软管的远端内部。
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公开(公告)号：US06440110B2
公开(公告)日：2002-08-27
申请号：US09740616
申请日：2000-12-18
IPC分类号： A61M100
CPC分类号： A61M1/02 , A61B5/150038 , A61B5/150045 , A61B5/150068 , A61B5/150213 , A61B5/150221 , A61B5/150366 , A61B5/150755 , A61M2202/0462
摘要： An apparatus and method for collecting a large volume of blood from an umbilical cord in a sterile environment are shown and described. A housing having an inner region adapted to retain an umbilical cord in a desired location is provided, the housing having an opening through which the cord extends from the inner region of the housing to a region external to the housing. The cord is cut by a blade coupled to the housing, either by the motion of the blade from a first position to a second position, or by the movement of two portions of the housing from a first extended position to a second collapsed position. The newly cut end of the umbilical cord falls and hangs freely in the inner region of the housing, blood flowing from the placenta and umbilical cord via gravity into a blood collection region of the housing. The blood collection region may be flexible, and may be coupled to a conventional blood collection bag.
摘要翻译： 显示和描述了用于在无菌环境中从脐带收集大量血液的装置和方法。 提供了具有适于将脐带保持在期望位置的内部区域的壳体，所述壳体具有开口，所述绳索通过所述开口从所述壳体的内部区域延伸到所述壳体外部的区域。 绳索由联接到壳体的叶片切割，或者通过叶片从第一位置到第二位置的运动，或者通过壳体的两个部分从第一延伸位置到第二收缩位置的运动来切割。 脐带的新切割端在房屋的内部区域自由落下并悬挂，血液从胎盘和脐带通过重力流入外壳的采血区域。 采集区域可以是柔性的，并且可以联接到常规采血袋。
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公开(公告)号：US06756031B2
公开(公告)日：2004-06-29
申请号：US10025791
申请日：2001-12-26
申请人： Scott Evans , Richard J. Greff , James I. Wright
发明人： Scott Evans , Richard J. Greff , James I. Wright
IPC分类号： A61K4904
CPC分类号： A61K9/0024
摘要： Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a polymer, a biocompatible solvent and a contrast agent. The polymer is selected from the group consisting of polyacrylonitrile, polyurethane, polyvinylacetate, cellulose acetate butyrate, nitrocellulose and copolymers of urethane/carbonate and copolymers of styrene/maleic acid.
摘要翻译： 公开了适合用于栓塞血管的组合物，其组合物包含聚合物，生物相容性溶剂和造影剂。 聚合物选自聚丙烯腈，聚氨酯，聚乙酸乙烯酯，乙酸丁酸纤维素，硝酸纤维素和氨基甲酸酯/碳酸酯的共聚物和苯乙烯/马来酸的共聚物。
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公开(公告)号：US5993429A
公开(公告)日：1999-11-30
申请号：US856252
申请日：1997-05-14
CPC分类号： A61M1/02 , A61B5/150038 , A61B5/150045 , A61B5/150068 , A61B5/150213 , A61B5/150221 , A61B5/150366 , A61B5/150755 , A61M2202/0462
摘要： An apparatus and method for collecting a large volume of blood from an umbilical cord in a sterile environment are shown and described. A housing having an inner region adapted to retain an umbilical cord in a desired location is provided, the housing having an opening through which the cord extends from the inner region of the housing to a region external to the housing. The cord is cut by a blade coupled to the housing, either by the motion of the blade from a first position to a second position, or by the movement of two portions of the housing from a first extended position to a second collapsed position. The newly cut end of the umbilical cord falls and hangs freely in the inner region of the housing, blood flowing from the placenta and umbilical cord via gravity into a blood collection region of the housing. The blood collection region may be flexible, and may be coupled to a conventional blood collection bag.
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公开(公告)号：US06858219B2
公开(公告)日：2005-02-22
申请号：US10394231
申请日：2003-03-24
申请人： Scott Evans , Richard J. Greff , James I. Wright
发明人： Scott Evans , Richard J. Greff , James I. Wright
IPC分类号： A61K31/785 , A61K9/00 , A61K31/717 , A61K31/765 , A61K33/24 , A61P7/04 , A61P9/00 , A61K9/08 , A61K17/30 , A61P13/16
CPC分类号： A61K9/0024
摘要： Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a polymer, a biocompatible solvent and a contrast agent. The polymer is selected from the group consisting of polyacrylonitrile, polyurethane, polyvinylacetate, cellulose acetate butyrate, nitrocellulose and copolymers of urethane/carbonate and copolymers of styrene/maleic acid.
摘要翻译： 公开了适合用于栓塞血管的组合物，其组合物包含聚合物，生物相容性溶剂和造影剂。 聚合物选自聚丙烯腈，聚氨酯，聚乙酸乙烯酯，乙酸丁酸纤维素，硝酸纤维素和氨基甲酸酯/碳酸酯的共聚物和苯乙烯/马来酸的共聚物。
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公开(公告)号：US06342202B1
公开(公告)日：2002-01-29
申请号：US08917721
申请日：1997-08-27
申请人： Scott Evans , Richard J. Greff , James I. Wright
发明人： Scott Evans , Richard J. Greff , James I. Wright
IPC分类号： A61K908
CPC分类号： A61K9/0024
摘要： Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a polymer, a biocompatible solvent and a contrast agent. The polymer is selected from the group consisting of polyacrylonitrile, polyurethane, polyvinylacetate, cellulose acetate butyrate, nitrocellulose and copolymers of urethane/carbonate and copolymers of styrene/maleic acid.
摘要翻译： 公开了适合用于栓塞血管的组合物，其组合物包含聚合物，生物相容性溶剂和造影剂。 聚合物选自聚丙烯腈，聚氨酯，聚乙酸乙烯酯，乙酸丁酸纤维素，硝酸纤维素和氨基甲酸酯/碳酸酯的共聚物和苯乙烯/马来酸的共聚物。
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8.发明授权公开(公告)号：US06296842B1
公开(公告)日：2001-10-02
申请号：US09638165
申请日：2000-08-10
IPC分类号： C08J936
CPC分类号： A61K9/1647 , A61K9/1694 , Y10S521/918
摘要： The invention relates to a sustained release composition and methods of forming and using said composition for the sustained release of biologically active agent. The sustained release compositions of the invention comprise a biocompatible polymer and a biologically active agent characterized by a porous center and a less porous outer layer wherein the center and outer layer consist of essentially the same materials. The sustained release compositions can be prepared by annealing at least a substantial portion of the exterior surface of a polymer/active agent matrix. The compositions which have been annealed exhibit a decrease in the release of agent over the first 24 hours following administration (i.e., reduced burst) and as a result can show an increase in the duration of sustained release thereby providing increased therapeutic benefits.
摘要翻译： 本发明涉及缓释组合物和形成和使用所述组合物以持续释放生物活性剂的方法。 本发明的持续释放组合物包含生物相容性聚合物和生物活性剂，其特征在于多孔中心和较少多孔外层，其中中心层和外层由基本上相同的材料组成。 持续释放组合物可以通过使至少大部分的聚合物/活性剂基质的外表面退火来制备。 已经退火的组合物在给药后的前24小时表现出试剂释放的降低（即，减少的爆发），结果可以显示持续释放的持续时间的增加，从而提供增加的治疗益处。
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公开(公告)号：US5919176A
公开(公告)日：1999-07-06
申请号：US742438
申请日：1996-10-30
CPC分类号： A61M1/02 , A61B5/150038 , A61B5/150045 , A61B5/150068 , A61B5/150213 , A61B5/150221 , A61B5/150366 , A61B5/150755 , A61M2202/0462
摘要： An apparatus and method for collecting a large volume of blood from an umbilical cord in a sterile environment are shown and described. A housing having an inner region adapted to retain an umbilical cord in a desired location is provided, the housing having an opening through which the cord extends from the inner region of the housing to a region external to the housing. The cord is cut by a blade coupled to the housing, either by the motion of the blade from a first position to a second position, or by the movement of two portions of the housing from a first extended position to a second collapsed position. The newly cut end of the umbilical cord falls and hangs freely in the inner region of the housing, blood flowing from the placenta and umbilical cord via gravity into a blood collection region of the housing. The blood collection region may be flexible, and may be coupled to a conventional blood collection bag.
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公开(公告)号：US07138106B2
公开(公告)日：2006-11-21
申请号：US10161606
申请日：2002-06-05
申请人： Scott Evans , Richard J. Greff , James I. Wright
发明人： Scott Evans , Richard J. Greff , James I. Wright
CPC分类号： A61K9/0024
摘要： Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a polymer, a biocompatible solvent and a contrast agent. The polymer is selected from the group consisting of polyacrylonitrile, polyurethane, polyvinylacetate, cellulose acetate butyrate, nitrocellulose and copolymers of urethane/carbonate and copolymers of styrene/maleic acid.
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