公开(公告)号：US20170189434A1

公开(公告)日：2017-07-06

申请号：US15463683

申请日：2017-03-20

申请人： Karl D. Normington ,  David A. Sinclair ,  David J. Livingston ,  James M. McKearin ,  Bruce Szczpankiewicz ,  Jonathan N. Kremsky

发明人： Karl D. Normington ,  David A. Sinclair ,  David J. Livingston ,  James M. McKearin ,  Bruce Szczpankiewicz ,  Jonathan N. Kremsky

IPC分类号： A61K31/706

CPC分类号： A61K31/706 ,  A61K31/443 ,  A61K31/661 ,  A61K31/665 ,  A61K31/7052 ,  C07F9/06 ,  C07F9/547 ,  C07F9/65586 ,  C07F9/6561 ,  C07F9/65742 ,  C07H11/04 ,  C07H19/04 ,  C07H19/048

摘要： The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

公开(公告)号：US20180147227A1

公开(公告)日：2018-05-31

申请号：US15877597

申请日：2018-01-23

申请人： Karl D. Normington ,  David A. Sinclair ,  David J. Livingston ,  James M. Mckearin ,  Bruce Szczpankiewicz ,  Jonathan N. Kremsky

发明人： Karl D. Normington ,  David A. Sinclair ,  David J. Livingston ,  James M. Mckearin ,  Bruce Szczpankiewicz ,  Jonathan N. Kremsky

IPC分类号： A61K31/706

CPC分类号： A61K31/706 ,  A61K31/443 ,  A61K31/661 ,  A61K31/665 ,  A61K31/7052 ,  C07F9/06 ,  C07F9/547 ,  C07F9/65586 ,  C07F9/6561 ,  C07F9/65742 ,  C07H11/04 ,  C07H19/04 ,  C07H19/048

摘要： The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

公开(公告)号：US06646157B2

公开(公告)日：2003-11-11

申请号：US09748306

申请日：2000-12-21

申请人： James M. McKearin

发明人： James M. McKearin

IPC分类号： C07C22900

CPC分类号： C07C251/24 ,  A61K31/195 ,  A61K31/198 ,  A61K45/06 ,  C07C215/50 ,  C07C227/02 ,  C07C227/18 ,  A61K2300/00 ,  C07C229/16

摘要： The preparation of a mono-cationic salt of N,N′-bis(2-hydroxybenzyl)-ethylenediamine-N,N′-diacetic acid (HBED) and HBED itself is disclosed. In particular, the invention relates to the hydrolysis of the t-butyl ester of HBED with a weak acid, such as formic acid, to form HBED, and the subsequent reaction with an equimolar amount of a base to form the mono-cationic salt.

摘要翻译： 公开了N，N'-双（2-羟基苄基） - 乙二胺-N，N'-二乙酸（HBED）和HBED本身的单阳离子盐的制备。 特别地，本发明涉及用弱酸如甲酸将HBED的叔丁酯水解形成HBED，随后与等摩尔量的碱反应形成单阳离子盐。