摘要:
The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
摘要:
The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
摘要:
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要:
The invention relates to detection and modulation of cytochrome c acetylation. The invention has diagnostic and therapeutic applications for neurodegenerative disorders and cancer.
摘要:
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要:
This invention relates to a method, system and computer program product for reading data from a storage controller in storage area network. A read data instruction is received from an application requesting data from the storage controller using a primary data path. If the data on the primary data path is not transferred in a defined time interval using the primary data path, data is requested from the storage controller using one or more alternative data paths. Data is received from the storage controller on one of data paths and into a buffer. When the read instruction has completed and that the data is in the buffer, the application is notified. Each data path is associated with a buffer and the data is received into a buffer associated with the path. The application is informed which buffer holds the data and the application accesses the data from this buffer.
摘要:
A computer-driven information management system selectively matches credit applicants with money lenders through a global communications network. The system includes an applicant data entry device for entering applicant data into the system. The applicant data defines an electronic applicant profile of a credit applicant seeking financing. A model data entry device is provided for entering model data into the system. The model data is established by the lender and defines an electronic model profile representing characteristics of a desired applicant. A filter electronically compares the applicant profile with the model profile, such that for those credit applicants matching the model profile, the applicant data is made available through the system to lender. For those credit applicants not matching the model profile, no applicant data is made available through the system to the lender.
摘要:
In a display system an array of data values such as, for example, an array of speech waveform samples, is represented in a display field by logically dividing the display field into a number of display areas and determining (e.g. in 16), for each value of the data array, the area of the display field within which that value should be displayed, comparing that value to a range for the area in question and updating the range to include that value if it lies outside the range previously defined for that area and then plotting, within each area of the display field, a line joining display screen positions defined by the range in the range storage for that area.
摘要:
Methods and compositions for preventing or treating peripheral neuropathy, cognitive deficits, inactivity, depression, chemotherapy and/or radiotherapy induced peripheral neuropathy and cognitive deficits, and improving cognitive performance, in a subject in need thereof are disclosed. The disclosed methods include the step of administering to the subject an effective amount of an agent that increases the level of NAD+ in the subject.
摘要:
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.