公开(公告)号：US09085582B2

公开(公告)日：2015-07-21

申请号：US13702177

申请日：2011-06-20

Applicant: James Matthew Bailey

Inventor： James Matthew Bailey

IPC: A61K31/5517 ,  C07D487/04 ,  A61K45/06

CPC classification number: C07D487/04 ,  A61K31/5517 ,  A61K45/06

Abstract: Benzodiazepine compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract translation: 苯并二氮杂类化合物，含有这些化合物的药物组合物及其在治疗中的用途。

公开(公告)号：US20130079335A1

公开(公告)日：2013-03-28

申请号：US13702177

申请日：2011-06-20

Applicant: James Matthew Bailey

Inventor： James Matthew Bailey

IPC: C07D487/04 ,  A61K45/06 ,  A61K31/5517

CPC classification number: C07D487/04 ,  A61K31/5517 ,  A61K45/06

Abstract: Benzodiazepine compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract translation: 苯并二氮杂类化合物，含有这些化合物的药物组合物及其在治疗中的用途。

公开(公告)号：US20120101086A1

公开(公告)日：2012-04-26

申请号：US13379110

申请日：2010-06-17

Applicant: James Matthew Bailey ,  John Alexander Brown ,  Emmanuel Hubert Demont ,  Lee Andrew Harrison ,  Gail Astra Lorraine Seal ,  Christian Alan Paul Smethurst ,  Jason Witherington

Inventor： James Matthew Bailey ,  John Alexander Brown ,  Emmanuel Hubert Demont ,  Lee Andrew Harrison ,  Gail Astra Lorraine Seal ,  Christian Alan Paul Smethurst ,  Jason Witherington

IPC: A61K31/55 ,  C07D487/04 ,  C07D471/04 ,  A61P25/00 ,  A61P37/00 ,  A61P29/00 ,  A61P11/06 ,  A61P19/02 ,  A61P41/00 ,  A61P1/00 ,  A61P35/00 ,  A61P35/04 ,  A61P7/00 ,  A61P31/12 ,  A61P3/10 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract translation: 本发明涉及具有药理活性的新化合物，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。

公开(公告)号：US20120094979A1

公开(公告)日：2012-04-19

申请号：US13378809

申请日：2010-06-17

Applicant: James Matthew Bailey ,  Emmanuel Hubert Demont ,  Xichen Lin ,  Feng Ren ,  Christian Alan Paul Smethurst

Inventor： James Matthew Bailey ,  Emmanuel Hubert Demont ,  Xichen Lin ,  Feng Ren ,  Christian Alan Paul Smethurst

IPC: A61K31/55 ,  A61K31/4725 ,  A61K31/433 ,  A61P25/00 ,  A61P37/06 ,  A61P29/00 ,  A61P11/06 ,  A61P19/02 ,  A61P1/00 ,  A61P17/06 ,  A61P9/10 ,  A61P35/00 ,  A61P35/04 ,  A61P9/00 ,  A61P31/12 ,  A61P3/10 ,  C07D417/10

CPC classification number: C07D417/04

Abstract: Thiazole or thiadizaloe derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptor are disclosed.

Abstract translation: 公开了具有药理活性的式（I）的噻唑或噻二唑衍生物或其药用盐，其制备方法，含有它们的药物组合物及其在治疗由S1P1受体介导的各种疾病中的用途。

公开(公告)号：US20120101083A1

公开(公告)日：2012-04-26

申请号：US13379059

申请日：2010-06-17

Applicant: James Matthew Bailey ,  Rino Antonio Bit ,  Emmanuel Hubert Demont ,  Lee Andrew Harrison ,  Katherine Louise Jones ,  Christian Alan Paul Smethurst ,  Jason Witherington

Inventor： James Matthew Bailey ,  Rino Antonio Bit ,  Emmanuel Hubert Demont ,  Lee Andrew Harrison ,  Katherine Louise Jones ,  Christian Alan Paul Smethurst ,  Jason Witherington

IPC: A61K31/55 ,  C07D417/10 ,  C07D413/14 ,  A61K31/4725 ,  A61P25/00 ,  A61P29/00 ,  A61P11/06 ,  A61P19/02 ,  A61P17/06 ,  A61P35/00 ,  A61P35/04 ,  A61P9/00 ,  A61P31/12 ,  A61P3/10 ,  C07D413/10

CPC classification number: C07D413/04 ,  C07D413/14 ,  C07D417/04

Abstract: The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract translation: 本发明涉及具有S1P1激动剂活性的新型式（I）化合物，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。