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1.THIADIAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF DISORDERS MEDIATED BY S1P1 RECEPTORS 审中-公开
标题翻译: 三唑衍生物及其用于治疗由S1P1受体介导的疾病的用途公开(公告)号:US20120101086A1
公开(公告)日:2012-04-26
申请号:US13379110
申请日:2010-06-17
申请人: James Matthew Bailey , John Alexander Brown , Emmanuel Hubert Demont , Lee Andrew Harrison , Gail Astra Lorraine Seal , Christian Alan Paul Smethurst , Jason Witherington
发明人: James Matthew Bailey , John Alexander Brown , Emmanuel Hubert Demont , Lee Andrew Harrison , Gail Astra Lorraine Seal , Christian Alan Paul Smethurst , Jason Witherington
IPC分类号: A61K31/55 , C07D487/04 , C07D471/04 , A61P25/00 , A61P37/00 , A61P29/00 , A61P11/06 , A61P19/02 , A61P41/00 , A61P1/00 , A61P35/00 , A61P35/04 , A61P7/00 , A61P31/12 , A61P3/10 , A61K31/437
CPC分类号: C07D471/04
摘要: The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译: 本发明涉及具有药理活性的新化合物,其制备方法,含有它们的药物组合物及其在治疗各种疾病中的用途。
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2.4-carboxamide indazole derivatives useful as inhibitors of PI3-kinases 有权
标题翻译: 可用作PI3激酶抑制剂的4-甲酰胺吲唑衍生物公开(公告)号:US08163743B2
公开(公告)日:2012-04-24
申请号:US12994246
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
IPC分类号: C07D231/56 , C07D401/04 , A61K31/416 , A61K31/4439 , A61P11/00
CPC分类号: C07D231/56
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是P13-激酶活性的抑制剂。
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3.THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS 审中-公开
标题翻译: 用作磷酸1-磷酸1(S1P1)受体激动剂的噻唑或十二烷基衍生物公开(公告)号:US20120094979A1
公开(公告)日:2012-04-19
申请号:US13378809
申请日:2010-06-17
申请人: James Matthew Bailey , Emmanuel Hubert Demont , Xichen Lin , Feng Ren , Christian Alan Paul Smethurst
发明人: James Matthew Bailey , Emmanuel Hubert Demont , Xichen Lin , Feng Ren , Christian Alan Paul Smethurst
IPC分类号: A61K31/55 , A61K31/4725 , A61K31/433 , A61P25/00 , A61P37/06 , A61P29/00 , A61P11/06 , A61P19/02 , A61P1/00 , A61P17/06 , A61P9/10 , A61P35/00 , A61P35/04 , A61P9/00 , A61P31/12 , A61P3/10 , C07D417/10
CPC分类号: C07D417/04
摘要: Thiazole or thiadizaloe derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptor are disclosed.
摘要翻译: 公开了具有药理活性的式(I)的噻唑或噻二唑衍生物或其药用盐,其制备方法,含有它们的药物组合物及其在治疗由S1P1受体介导的各种疾病中的用途。
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公开(公告)号:US08658635B2
公开(公告)日:2014-02-25
申请号:US12994250
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/55 , A61K31/5377 , A61K31/501 , A61K31/496 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/4523 , A61K31/4427 , A61K31/427 , A61K31/425 , C07D267/02 , C07D279/12 , C07D295/00 , C07D265/30 , C07D413/14 , C07D487/12 , C07D417/12 , C07D211/00 , C07D277/20 , C07D235/00 , C07D233/54 , C07D403/14
CPC分类号: C07D231/56
摘要: The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及某些新的式(I)化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US08536169B2
公开(公告)日:2013-09-17
申请号:US12994254
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Joelle Le , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Joelle Le , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/5377 , A61K31/416 , A61K31/454 , A61K31/4439 , C07D401/14 , C07D403/04 , C07D413/14
CPC分类号: C07D403/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04
摘要: The invention is directed to certain novel compounds directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及针对式(I)化合物及其盐的某些新化合物。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US20120245171A1
公开(公告)日:2012-09-27
申请号:US13513063
申请日:2010-12-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Paul Spencer Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Paul Spencer Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/4985 , C07D417/14 , A61K31/496 , C07D413/14 , A61K31/5377 , C07D471/04 , A61P37/00 , A61P29/00 , A61P9/00 , A61P35/00 , A61P25/28 , A61P1/18 , A61P13/12 , A61P7/04 , A61P15/08 , A61P37/06 , A61P11/00 , A61P25/00 , A61P11/06 , A61P37/08 , A61P17/00 , A61P1/00 , A61P7/02 , A61P9/10 , C07D487/04
CPC分类号: C07D487/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/04 , C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US20120101083A1
公开(公告)日:2012-04-26
申请号:US13379059
申请日:2010-06-17
申请人: James Matthew Bailey , Rino Antonio Bit , Emmanuel Hubert Demont , Lee Andrew Harrison , Katherine Louise Jones , Christian Alan Paul Smethurst , Jason Witherington
发明人: James Matthew Bailey , Rino Antonio Bit , Emmanuel Hubert Demont , Lee Andrew Harrison , Katherine Louise Jones , Christian Alan Paul Smethurst , Jason Witherington
IPC分类号: A61K31/55 , C07D417/10 , C07D413/14 , A61K31/4725 , A61P25/00 , A61P29/00 , A61P11/06 , A61P19/02 , A61P17/06 , A61P35/00 , A61P35/04 , A61P9/00 , A61P31/12 , A61P3/10 , C07D413/10
CPC分类号: C07D413/04 , C07D413/14 , C07D417/04
摘要: The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译: 本发明涉及具有S1P1激动剂活性的新型式(I)化合物,其制备方法,含有它们的药物组合物及其在治疗各种疾病中的用途。
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公开(公告)号:US20110183973A1
公开(公告)日:2011-07-28
申请号:US12994254
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Paul Spencer Jones , Joelle Le , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Paul Spencer Jones , Joelle Le , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/5377 , C07D231/56 , A61K31/416 , C07D401/14 , A61K31/454 , C07D413/14 , A61K31/4439 , A61P35/00 , A61P3/00 , A61P7/00 , A61P11/00 , A61P19/00 , A61P25/04 , A61P29/00 , A61P37/06
CPC分类号: C07D403/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04
摘要: The invention is directed to certain novel compounds directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及针对式(I)化合物及其盐的某些新化合物。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US20110118246A1
公开(公告)日:2011-05-19
申请号:US12994253
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/4439 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/4545 , A61K31/496 , C07D405/14 , C07D471/04 , A61K31/4985 , A61K31/444 , C07D417/14 , A61K31/541 , A61P11/00 , A61P11/06 , A61P25/28 , A61P35/00 , A61P37/06 , A61P29/00 , A61P9/10
CPC分类号: C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要: The invention is directed to to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及式(I)化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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10.4-CARBOXAMIDE INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF P13-KINASES 有权
标题翻译: 用作P13-激酶抑制剂的4-羧酰胺吲哚衍生物公开(公告)号:US20110112070A1
公开(公告)日:2011-05-12
申请号:US12994246
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
IPC分类号: A61K31/416 , C07D401/12 , C07D231/56 , C07D417/14 , C07D417/12 , C07D413/14 , A61K31/4439 , A61K31/427 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/541 , A61K31/553 , A61P11/00
CPC分类号: C07D231/56
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是P13-激酶活性的抑制剂。
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