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公开(公告)号：US20110177076A1
公开(公告)日：2011-07-21
申请号：US13052597
申请日：2011-03-21
Applicant: Lisa Lynn Shafer , Francis Joseph Carr , James Peter Gregson , Dawn Ann Bembridge , Tim Jones
Inventor： Lisa Lynn Shafer , Francis Joseph Carr , James Peter Gregson , Dawn Ann Bembridge , Tim Jones
CPC classification number: C07K16/18 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/56
Abstract: Humanized anti-Aβ antibodies derived from a murine antibody directed to a N-terminal epitope of Aβ are described. The humanized antibodies have reduced or no human T cell epitopes and bind Aβ with an affinity similar to that of the murine antibody.
Abstract translation: 人性化反A＆BGR 衍生自针对A＆amp; Bgr的N末端表位的鼠抗体的抗体; 被描述。 人源化抗体具有减少或没有人T细胞表位并结合A＆bgr; 具有与鼠抗体相似的亲和力。
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公开(公告)号：US07931899B2
公开(公告)日：2011-04-26
申请号：US12323682
申请日：2008-11-26
Applicant: Lisa Lynn Shafer , Francis Joseph Carr , James Peter Gregson , Dawn Ann Bembridge , Tim Jones
Inventor： Lisa Lynn Shafer , Francis Joseph Carr , James Peter Gregson , Dawn Ann Bembridge , Tim Jones
IPC: A61K39/395 , C12P21/08
CPC classification number: C07K16/18 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/56
Abstract: Humanized anti-Aβ antibodies derived from a murine antibody directed to a N-terminal epitope of Aβ are described. The humanized antibodies have reduced or no human T cell epitopes and bind Aβ with an affinity similar to that of the murine antibody.
Abstract translation: 人性化反A＆BGR 衍生自针对A＆amp; Bgr的N末端表位的鼠抗体的抗体; 被描述。 人源化抗体具有减少或没有人T细胞表位并结合A＆bgr; 具有与鼠抗体相似的亲和力。
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公开(公告)号：US08614298B2
公开(公告)日：2013-12-24
申请号：US13052597
申请日：2011-03-21
Applicant: Lisa Lynn Shafer , Francis Joseph Carr , James Peter Gregson , Dawn Ann Bembridge , Tim Jones
Inventor： Lisa Lynn Shafer , Francis Joseph Carr , James Peter Gregson , Dawn Ann Bembridge , Tim Jones
IPC: C07K16/46 , C07K16/18 , A61K39/395 , A61M5/14 , A61K9/08
CPC classification number: C07K16/18 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/56
Abstract: Humanized anti-Aβ antibodies derived from a murine antibody directed to a N-terminal epitope of Aβ are described. The humanized antibodies have reduced or no human T cell epitopes and bind Aβ with an affinity similar to that of the murine antibody.
Abstract translation: 描述了源自针对Abeta的N末端表位的鼠抗体的人源化抗Aβ抗体。 人源化抗体具有减少或没有人T细胞表位并以与鼠抗体相似的亲和性结合Aβ。
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公开(公告)号：US20090175923A1
公开(公告)日：2009-07-09
申请号：US12323682
申请日：2008-11-26
Applicant: Lisa Lynn Shafer , Francis Joseph Carr , James Peter Gregson , Dawn Ann Bembridge , Tim Jones
Inventor： Lisa Lynn Shafer , Francis Joseph Carr , James Peter Gregson , Dawn Ann Bembridge , Tim Jones
CPC classification number: C07K16/18 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/56
Abstract: Humanized anti-Aβ antibodies derived from a murine antibody directed to a N-terminal epitope of Aβ are described. The humanized antibodies have reduced or no human T cell epitopes and bind Aβ with an affinity similar to that of the murine antibody.
Abstract translation: 描述了源自针对Abeta的N末端表位的鼠抗体的人源化抗Aβ抗体。 人源化抗体具有减少或没有人T细胞表位并以与鼠抗体相似的亲和性结合Aβ。
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