公开(公告)号：US20160016948A1

公开(公告)日：2016-01-21

申请号：US14745159

申请日：2015-06-19

申请人： Marian C. Bryan ,  Bryan Chan ,  Emily Hanan ,  Timothy Heffron ,  Hans Purkey ,  Richard Leonard Elliott ,  Robert Heald ,  Jamie Knight ,  Michael Lainchbury ,  Eileen M. Seward

发明人： Marian C. Bryan ,  Bryan Chan ,  Emily Hanan ,  Timothy Heffron ,  Hans Purkey ,  Richard Leonard Elliott ,  Robert Heald ,  Jamie Knight ,  Michael Lainchbury ,  Eileen M. Seward

IPC分类号： C07D471/04 ,  A61K45/06 ,  C07D498/10 ,  A61K31/5355 ,  A61K31/541 ,  C07D498/08 ,  A61K31/538 ,  C07D491/107 ,  A61K31/506 ,  A61K31/5377

CPC分类号： C07D471/04 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K45/06 ,  C07D491/107 ,  C07D498/08 ,  C07D498/10 ,  C07D519/00

摘要： This invention relates to novel compounds which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer.

摘要翻译： 本发明涉及作为含有EGFR突变体的T790M抑制剂的新化合物，含有它们的药物组合物，其制备方法及其在治疗中用于预防或治疗癌症的新化合物。

公开(公告)号：US07356619B2

公开(公告)日：2008-04-08

申请号：US10142606

申请日：2002-05-09

申请人： Gary Dean Anderson ,  Richard Jamie Knight ,  Jayeshkumar M. Patel

发明人： Gary Dean Anderson ,  Richard Jamie Knight ,  Jayeshkumar M. Patel

IPC分类号： G06F3/00 ,  G06F13/00

CPC分类号： G06F12/0653

摘要： A method, apparatus, and computer instructions for managing a set of I/O subsystems. Previously stored I/O subsystem information is compared to current I/O subsystem information collected from the set of I/O subsystems. The I/O subsystem information includes addresses associated with unique identifiers. Information in the set of subsystems is recorrelated if a mismatch is present between the previously stored I/O subsystem information and the current I/O subsystem information in the set of subsystems.

摘要翻译： 一种用于管理一组I / O子系统的方法，装置和计算机指令。 先前存储的I / O子系统信息与从I / O子系统集合中收集的当前I / O子系统信息进行比较。 I / O子系统信息包括与唯一标识符相关联的地址。 如果先前存储的I / O子系统信息和子系统集合中的当前I / O子系统信息之间存在不匹配，则子系统集合中的信息将被重新关联。

公开(公告)号：US20120088763A1

公开(公告)日：2012-04-12

申请号：US13201716

申请日：2010-02-16

申请人： Harry Finch ,  John Montana ,  Monique Bodil Van Niel ,  Chi-Kit Woo ,  Jamie Knight ,  Bohdan Waszkowycz

发明人： Harry Finch ,  John Montana ,  Monique Bodil Van Niel ,  Chi-Kit Woo ,  Jamie Knight ,  Bohdan Waszkowycz

IPC分类号： A61K31/5377 ,  A61P11/00 ,  A61P11/06 ,  C07D471/04 ,  A61K31/437

CPC分类号： C07D471/04

摘要： Compounds of formula (I) are inhibitors of p38 MAP kinase, useful as anti-inflammatory agents in the treatment of inter alia, diseases of the respiratory tract wherein; R1 is C1-C6 alkyl, C3-C6 cycloalkyl, phenyl which is optionally substituted, 5- or 6 membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II) wherein n is 1 or 2, and R3 and R4 are independently H or C1-C6 alkyl, or R3 and R4 taken together with the nitrogen to which they are attached form a 6-membered heterocyclic ring optionally containing a further heteroatom selected from N and O; Y is —O— or —S(O)p— wherein p is 0, 1 or 2; A is an optionally substituted divalent arylene radical, or a mono- or bicyclic heteroarylene radical, or a C3-C6 divalent cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to R2NHC(═O)W—; W is a bond, —NH— or —C(RA)(RB), wherein RA and RB are independently H, methyl, ethyl, amino, hydroxyl or halo; and R2 is a radical as defined in the claims.

摘要翻译： 式（I）化合物是p38MAP激酶的抑制剂，其可用作治疗特别是呼吸道疾病的抗炎剂，其中： R 1是C 1 -C 6烷基，C 3 -C 6环烷基，任选取代的苯基，任选被取代的5-或6-元单环杂芳基，或其中n是1或2的式（II）基团，R 3和R 4是 独立地是H或C 1 -C 6烷基，或者R 3和R 4与它们所连接的氮一起形成任选含有另外选自N和O的杂原子的6元杂环; Y是-O-或-S（O）p - ，其中p是0,1或2; A是任选取代的二价亚芳基，或单环或双环亚杂芳基或具有5或6个环原子的C 3 -C 6二价亚环烷基或哌啶子基，其中环氮连接至R 2 NHC（= O）W - ; W是键，-NH-或-C（RA）（RB），其中RA和RB独立地是H，甲基，乙基，氨基，羟基或卤素; 并且R 2是如权利要求中所定义的基团。

公开(公告)号：US08557797B2

公开(公告)日：2013-10-15

申请号：US13201716

申请日：2010-02-16

申请人： Harry Finch ,  John Montana ,  Monique Bodil Van Niel ,  Chi-Kit Woo ,  Jamie Knight ,  Bohdan Waszkowycz

发明人： Harry Finch ,  John Montana ,  Monique Bodil Van Niel ,  Chi-Kit Woo ,  Jamie Knight ,  Bohdan Waszkowycz

IPC分类号： A61K31/535 ,  A01N43/54 ,  C07D413/04 ,  C07D239/02

CPC分类号： C07D471/04

摘要： Compounds of formula (I) are inhibitors of p38 MAP kinase, useful as anti-inflammatory agents in the treatment of inter alia, diseases of the respiratory tract wherein; R1 is C1-C6 alkyl, C3-C6 cycloalkyl, phenyl which is optionally substituted, 5- or 6 membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II) wherein n is 1 or 2, and R3 and R4 are independently H or C1-C6 alkyl, or R3 and R4 taken together with the nitrogen to which they are attached form a 6-membered heterocyclic ring optionally containing a further heteroatom selected from N and O; Y is —O— or —S(O)p— wherein p is 0, 1 or 2; A is an optionally substituted divalent arylene radical, or a mono- or bicyclic heteroarylene radical, or a C3-C6 divalent cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to R2NHC(═O)W—; W is a bond, —NH— or —C(RA)(RB), wherein RA and RB are independently H, methyl, ethyl, amino, hydroxyl or halo; and R2 is a radical as defined in the claims.

摘要翻译： 式（I）化合物是p38MAP激酶的抑制剂，其可用作治疗特别是呼吸道疾病的抗炎剂，其中： R 1是C 1 -C 6烷基，C 3 -C 6环烷基，任选取代的苯基，任选被取代的5-或6-元单环杂芳基，或其中n是1或2的式（II）基团，R 3和R 4是 独立地是H或C 1 -C 6烷基，或者R 3和R 4与它们所连接的氮一起形成任选含有另外选自N和O的杂原子的6元杂环; Y是-O-或-S（O）p - ，其中p是0,1或2; A是任选取代的二价亚芳基或单环或双环亚杂芳基或具有5或6个环原子的C 3 -C 6二价亚环烷基或哌啶子基，其中环氮连接至R 2 NHC（= O）W - ; W是键，-NH-或-C（RA）（RB），其中RA和RB独立地是H，甲基，乙基，氨基，羟基或卤素; 并且R 2是如权利要求中所定义的基团。

公开(公告)号：US20070161672A1

公开(公告)日：2007-07-12

申请号：US11635786

申请日：2006-12-08

申请人： John Ford ,  David Madge ,  Helen Payne ,  Jamie Knight

发明人： John Ford ,  David Madge ,  Helen Payne ,  Jamie Knight

IPC分类号： A61K31/4743 ,  C07D498/02

CPC分类号： C07D495/04

摘要： Thienopyridine compounds which are potassium channel inhibitors are described. Pharmaceutical compositions comprising the compounds and their use in the treatment or prevention of cancer, arrhythmias, autoimmune diseases and inflammatory diseases, including gastric cancer, atrial fibrillation, type-2 diabetes mellitus, rheumatoid arthritis, type-1 diabetes, inflammatory bowel disorder and demyelinating disorders such as multiple sclerosis are also disclosed.

摘要翻译： 描述了作为钾通道抑制剂的噻吩并吡啶化合物。 包含该化合物的药物组合物及其在治疗或预防癌症，心律不齐，自身免疫性疾病和炎性疾病中的用途，包括胃癌，心房颤动，2型糖尿病，类风湿性关节炎，1型糖尿病，炎症性肠病和脱髓鞘 还公开了多发性硬化的病症。