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公开(公告)号：US5109132A
公开(公告)日：1992-04-28
申请号：US581518
申请日：1990-09-10
IPC分类号： A61K31/545 , C07D20060101 , C07D501/00 , C07D501/04 , C07D501/14 , C07D501/18 , C07D501/22 , C07D501/24 , C07D501/40 , C07F9/28 , C07F9/54 , C07F9/547 , C07F9/6547
CPC分类号： C07D501/04 , C07D501/14
摘要： A process is provided for the preparation of 3-methylene and 3-halomethylene cepham derivatives via 3-phosphoniomethyl-3-cephem derivatives, which in turn can be prepared from 3-halomethyl-3-cephem derivatives. The preparation can be carried out with or without isolating the intermediate phosphonium cephem compounds. The 3-methylene and 3-halomethylene cepham derivatives and in particular the 1-oxo and 1,1-dioxo cepham compounds are also prepared by reducing a 3-halomethyl-3-cepham derivative with activated metal, preferably zinc or magnesium.
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公开(公告)号：US4182870A
公开(公告)日：1980-01-08
申请号：US937989
申请日：1978-08-30
IPC分类号： A61K20060101 , C07D20060101 , C07D501/00 , C07D501/02 , C07D501/04 , C07D501/22 , C07D501/24 , C07F7/18
CPC分类号： C07D501/04 , Y02P20/582
摘要： An improved process for the preparation of 3-bromomethyl-3-cephem sulfoxide derivatives of the formula ##STR1## wherein R.sub.1 is an acylamido group and R.sub.2 is a group protecting the carboxy radical which are valuable intermediates for the preparation of various therapeutically useful cephalosporanic acid derivatives.
摘要翻译： 一种制备下式的3-溴甲基-3-头孢烯亚砜衍生物的改进方法，其中R1是酰氨基，R2是保护羧基的基团，它们是制备各种治疗上有用的头孢菌素的有价值的中间体 酸衍生物。
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3.发明授权Preparation of 3-exomethylenecepham sulfoxides and 2-chlorosulfinylazetidinones using molecular sieves 失效使用分子筛制备3-EXOMETLENECEPHAM SULFOXIDES和2-CHLOROSULFINYLAZETININESES
公开(公告)号：US5053501A
公开(公告)日：1991-10-01
申请号：US497541
申请日：1990-03-21
IPC分类号： C07D205/095 , C07D501/00 , C07D501/10 , C07D501/14 , C07D501/22
CPC分类号： C07D205/095 , C07D501/00
摘要： 3-Exomethylenecepham sulfoxide derivatives and intermediates therefor, viz. 2-chlorosulfinylazetidin-4-ones are prepared in high yield and purity by reaction of a penam sulfoxide ester with a N-chloro halogenating agent in the presence of molecular sieves.
摘要翻译： 3-亚甲基头孢烯亚砜衍生物及其中间体，即 2-氯亚磺酰基氮杂环丁烷-4-酮通过在分子筛存在下与亚氯酸盐与N-氯卤化剂反应而以高产率和纯度制备。
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公开(公告)号：US4985554A
公开(公告)日：1991-01-15
申请号：US337525
申请日：1989-02-15
IPC分类号： A61K31/545 , C07D20060101 , C07D501/00 , C07D501/04 , C07D501/14 , C07D501/18 , C07D501/22 , C07D501/24 , C07D501/40 , C07F9/28 , C07F9/54 , C07F9/547 , C07F9/6547
CPC分类号： C07D501/04 , C07D501/14
摘要： A process is provided for the preparation of 3-methylene and 3-halomethylene cepham derivatives via 3-phosphoniomethyl-3-cephem derivatives, which in turn can be prepared from 3-halomethyl-3-cephem derivatives. The preparation can be carried out with or without isolating the intermediate phosphonium cephem compounds. The 3-methylene and 3-halomethylene cepham derivatives and in particular the 1-oxo and 1,1-dioxo cepham compounds are also prepared by reducing a 3-halomethyl-3-cephem derivative with activated metal, preferably zinc or magnesium.
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