公开(公告)号：US20080192996A1

公开(公告)日：2008-08-14

申请号：US11817801

申请日：2006-03-09

Applicant: Jan Timmer ,  Robert Johannes Frederick Homan ,  Pieter Maria Mielekamp

Inventor： Jan Timmer ,  Robert Johannes Frederick Homan ,  Pieter Maria Mielekamp

IPC: G06K9/00

CPC classification number: A61B6/4441 ,  G06T7/35 ,  G06T2207/30004 ,  Y10S128/922

Abstract: Prior to an intervention, a 3D rotational scan is acquired (at block 10) in respect of a body volume and reconstructed. In addition, three-dimensional image data in respect of the body volume is acquired (at block 12) using another modality, such as computerised tomography (CT) or magnetic resonance (MR), reconstructed, and prepared for visualisation. During the actual intervention, live two-dimensional fluoroscopic images are acquired (at block 14), using the imaging system employed to acquire the 3D rotational scan, and processed for visualisation. The 2D image data is registered (at block 16) to the 3D rotational image data acquired and reconstructed in respect of the body volume of interest, and then a 3D-3D registration process is employed (at block 18) to register the 3D image data acquired in respect of the same body volume using, for example, CT or MR imaging systems to the 3D rotational image data, and a display module (20) is used to align the 2D fluoroscopic image and the 3D MR/CT image as a fused or composite image and display the image.

Abstract translation: 在干预之前，相对于身体体积获取3D重新扫描（在方框10）并重构。 此外，使用诸如计算机断层摄影（CT）或磁共振（MR）之类的另一种模式，获取关于体积的三维图像数据（方框12），并重建并准备用于可视化。 在实际干预过程中，使用用于获取3D旋转扫描的成像系统获取活体二维透视图像（在方框14），并进行可视化处理。 将2D图像数据（方框16）登记到相对于感兴趣的身体体积获取和重建的3D旋转图像数据，然后采用3D-3D注册处理（在框18处）以登记3D图像数据 使用例如CT或MR成像系统相对于3D旋转图像数据获得相同体积的体积，并且显示模块（20）用于将2D透视图像和3D MR / CT图像对准为融合 或合成图像并显示图像。

公开(公告)号：US06751286B2

公开(公告)日：2004-06-15

申请号：US10150053

申请日：2002-05-16

Applicant: Jan Timmer

Inventor： Jan Timmer

IPC: G01N2304

CPC classification number: G06T11/005

Abstract: A computed-tomography system comprises a data-processing system arranged to receive attenuation profiles for respective orientations. A lowest representative noise level of the individual attenuation profiles is determined. The attenuation profiles are filtered in dependence of said lowest representative noise level. In particular it is achieved that the filtered attenuation profiles have the lowest maximum noise level among the received attenuation profiles.

Abstract translation: 计算机断层摄影系统包括被布置为接收各个取向的衰减曲线的数据处理系统。 确定各个衰减曲线的最低代表性噪声水平。 根据所述最低代表性噪声电平对衰减曲线进行滤波。 特别地，实现了滤波的衰减分布在接收的衰减分布中具有最低的最大噪声电平。

公开(公告)号：US08208708B2

公开(公告)日：2012-06-26

申请号：US12294626

申请日：2007-03-15

Applicant: Robert Johannes Frederik Homan ,  Drazenko Babic ,  Pieter Maria Mielekamp ,  Jan Timmer

Inventor： Robert Johannes Frederik Homan ,  Drazenko Babic ,  Pieter Maria Mielekamp ,  Jan Timmer

IPC: G06K9/00

CPC classification number: A61B90/36 ,  A61B6/4441 ,  A61B34/10 ,  A61B2018/2025 ,  A61B2034/107 ,  A61B2090/364 ,  A61B2090/366

Abstract: According to an exemplary embodiment a targeting method for targeting a first object from an entry point to a target point in an object (110) under examination is provided, wherein the method comprises selecting a two-dimensional image (301) of the object under examination depicting the entry point (305) and the target point (303) and determining a planned path (304) from the entry point to the target point, wherein the planned path has a first direction. Furthermore, the method comprises recording data representing a fluoroscopic image of the object under examination, wherein the fluoroscopic image is recorded under a second direction so that a normal of the image coincide with the first direction and determining whether the first object is on the determined planned path based on shape and/or position of the projection of the first object in the fluoroscopic image.

Abstract translation: 根据示例性实施例，提供了一种用于将第一对象从检查对象（110）中的入口点定位到目标点的目标方法，其中，所述方法包括选择被检查对象的二维图像（301） 描绘入口点（305）和目标点（303），并从入口点到目标点确定计划路径（304），其中计划路径具有第一方向。 此外，该方法包括记录表示所检查对象的透视图像的数据，其中在第二方向上记录荧光透视图像，使得图像的法线与第一方向一致并且确定第一对象是否在确定的计划 基于第一物体在透视图像中的投影的形状和/或位置的路径。

公开(公告)号：US20090310754A1

公开(公告)日：2009-12-17

申请号：US12374391

申请日：2007-07-10

Applicant: Jan Timmer ,  Peter George Van De Haar

Inventor： Jan Timmer ,  Peter George Van De Haar

IPC: G01D18/00

CPC classification number: G01D18/00 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/4291 ,  A61B6/5258 ,  A61B6/5282 ,  A61B6/583 ,  A61B6/585

Abstract: It is described a gain calibration for a two-dimensional X-ray detector (315), in which the gain coefficients for scattered radiation (307b) and direct radiation (307a) are measured or estimated separately. A weighed average may be applied on the appropriate scatter fraction. The scatter fraction depending gain calibration method produces less ring artifacts in X-ray images as compared to known gain calibration methods, which do not take into account the fraction of scattered radiation reaching the X-ray detector (315).

Abstract translation: 描述了用于二维X射线检测器（315）的增益校准，其中散射辐射（307b）和直接辐射（307a）的增益系数被分别测量或估计。 加权平均值可以应用于适当的分散分数。 与已知的增益校准方法相比，散射分数依赖性增益校准方法在X射线图像中产生较少的环形伪影，其不考虑到到达X射线检测器的散射辐射的分数（315）。

公开(公告)号：US08249213B2

公开(公告)日：2012-08-21

申请号：US13058197

申请日：2009-08-11

Applicant: Nicolaas Jan Noordhoek ,  Jan Timmer

Inventor： Nicolaas Jan Noordhoek ,  Jan Timmer

IPC: A61B6/00 ,  G01D18/00

CPC classification number: A61B6/583 ,  A61B6/027

Abstract: The present invention refers to 3D rotational X-ray imaging systems for use in computed tomography (CT) and, more particularly, to a fast, accurate and mathematically robust calibration method for determining the effective center of rotation (I) in not perfectly isocentric 3D rotational C-arm systems and eliminating substantially circular ring artifacts (RA) which arise when using such a CT scanner system for acquiring a set of 2D projection images of an object of interest to be three-dimensionally reconstructed. For this purpose, a C-arm based rotational CT scanner comprising at least one radiation detector (D) having an X-radiation sensitive surface exposed to an X-ray beam emitted by at least one X-ray tube (S), each rotating along a non-ideal circular trajectory (TF, TCD) about an object of interest to be three-dimensionally reconstructed from a set of 2D projection images is used for providing geometrical calibration data by scanning a calibration phantom from a plurality of distinct projection directions and calculating, for each projection direction, the 3D positions of the X-ray tube's focal spot and the X-ray detector's center. For approximating the exact 3D position and angular direction of the axis of rotation about which the at least one X-ray tube and the at least one radiation detector rotate, a circular regression technique using a number of mathematically robust least squares fits is applied.

Abstract translation: 本发明涉及用于计算机断层摄影（CT）的3D旋转X射线成像系统，更具体地，涉及用于在不完全同心的3D中确定有效旋转中心（I）的快速，准确和数学上鲁棒的校准方法 旋转C形臂系统，并且消除了当使用这种CT扫描器系统获取要被三维重建的感兴趣对象的一组2D投影图像时出现的大致圆形的环形假象（RA）。 为此目的，一种基于C臂的旋转CT扫描仪，其包括至少一个辐射检测器（D），其具有暴露于由至少一个X射线管（S）发射的X射线束的X射线敏感表面，每个旋转 沿着从一组2D投影图像三维地重构的关于感兴趣对象的非理想圆弧轨迹（TF，TCD）用于通过从多个不同的投影方向扫描校准体模来提供几何校准数据，以及 对于每个投射方向，计算X射线管的焦斑和X射线检测器的中心的3D位置。 为了近似至少一个X射线管和至少一个辐射探测器旋转的旋转轴的精确3D位置和角度方向，应用使用多个数学鲁棒的最小二乘拟合的循环回归技术。

公开(公告)号：US20100172541A1

公开(公告)日：2010-07-08

申请号：US12294626

申请日：2007-03-15

Applicant: Robert Johannes Frederik Homan ,  Drazenko Babic ,  Pieter Maria Mielekamp ,  Jan Timmer

Inventor： Robert Johannes Frederik Homan ,  Drazenko Babic ,  Pieter Maria Mielekamp ,  Jan Timmer

IPC: G06K9/00

CPC classification number: A61B90/36 ,  A61B6/4441 ,  A61B34/10 ,  A61B2018/2025 ,  A61B2034/107 ,  A61B2090/364 ,  A61B2090/366

Abstract: According to an exemplary embodiment a targeting method for targeting a first object from an entry point to a target point in an object (110) under examination is provided, wherein the method comprises selecting a two-dimensional image (301) of the object under examination depicting the entry point (305) and the target point (303) and determining a planned path (304) from the entry point to the target point, wherein the planned path has a first direction. Furthermore, the method comprises recording data representing a fluoroscopic image of the object under examination, wherein the fluoroscopic image is recorded under a second direction so that a normal of the image coincide with the first direction and determining whether the first object is on the determined planned path based on shape and/or position of the projection of the first object in the fluoroscopic image.

Abstract translation: 根据示例性实施例，提供了一种用于将第一对象从检查对象（110）中的入口点定位到目标点的目标方法，其中，所述方法包括选择被检查对象的二维图像（301） 描绘入口点（305）和目标点（303），并从入口点到目标点确定计划路径（304），其中计划路径具有第一方向。 此外，该方法包括记录表示所检查对象的透视图像的数据，其中在第二方向上记录荧光透视图像，使得图像的法线与第一方向一致并且确定第一对象是否在确定的计划 基于第一物体在透视图像中的投影的形状和/或位置的路径。

公开(公告)号：US06269141B1

公开(公告)日：2001-07-31

申请号：US09368850

申请日：1999-08-05

Applicant: Roland Proksa ,  Jan Timmer

Inventor： Roland Proksa ,  Jan Timmer

IPC: A61B600

CPC classification number: A61B6/032 ,  A61B6/027 ,  G01N23/046 ,  G01N2223/419

Abstract: The invention relates to a computer tomography apparatus in which the scanning trajectory is shaped as a helix and a conical radiation beam traverses the examination zone. According to the invention, the dimension of the detector window (or the part thereof which is used for the reconstruction) is a factor of 3, 5, 7 . . . larger than the distance between neighboring turns of the helix. Using this geometry, each voxel in the examination zone is irradiated exactly from an angular range of 3&pgr;, 5&pgr;, 7&pgr; . . . when it traverses the cone beam. Such data acquisition yields an improved image quality.

Abstract translation: 本发明涉及一种计算机断层摄影装置，其中扫描轨迹成形为螺旋形，锥形辐射束穿过检查区。 根据本发明，检测器窗口（或其用于重构的部分）的尺寸是3,5,7的因子。 。 。 大于螺旋的相邻匝间的距离。 使用这种几何形状，检查区域中的每个体素从3pi，5pi，7pi的角度范围精确地照射。 。 。 当它穿过锥形束时。 这种数据采集产生了改进的图像质量。

公开(公告)号：US5905809A

公开(公告)日：1999-05-18

申请号：US665592

申请日：1996-06-18

Applicant: Jan Timmer

Inventor： Jan Timmer

IPC: A61B6/03 ,  G06T11/00 ,  G06K9/00 ,  G06K9/40 ,  G06K9/64 ,  G06T15/316

CPC classification number: G06T11/005 ,  G06T11/008

Abstract: A patient (7) is irradiated by an X-ray source (1) in a computed tomography apparatus. The radiation is subsequently detected by the detector cells (5) of a position-sensitive X-ray detection system (4) and the intensities detected are applied to a computing device (16). Absorption as well as elastic and inelastic scattering of X-rays occur within the patient (7). The data acquired is corrected for elastic (coherent) scatter by deriving a deconvolution function from the elastic scatter function, which deconvolution function is applied to the data. The elastic scatter function is determined, for example by a computer simulation.

Abstract translation: 在计算机断层摄影装置中，由X射线源（1）照射患者（7）。 随后由位置敏感的X射线检测系统（4）的检测器单元（5）检测辐射，并且检测到的强度被施加到计算设备（16）。 X射线的吸收以及弹性和非弹性散射发生在患者体内（7）。 通过从弹性散射函数导出去卷积函数，将解卷积函数应用于数据，获得的数据被校正为弹性（相干）散射。 例如通过计算机模拟确定弹性散射函数。

公开(公告)号：US08440987B2

公开(公告)日：2013-05-14

申请号：US13225045

申请日：2011-09-02

Applicant: Thomas Stephani ,  Uwe Behrens ,  Heinrich Roecken ,  Jan Timmer ,  Christian Baumgarten

Inventor： Thomas Stephani ,  Uwe Behrens ,  Heinrich Roecken ,  Jan Timmer ,  Christian Baumgarten

IPC: A61N5/10 ,  H01J3/14 ,  G21K5/00

CPC classification number: H05H7/02 ,  A61N5/10 ,  A61N5/1077 ,  A61N2005/1087 ,  H01J3/14 ,  H05H13/005 ,  H05H2007/122 ,  H05H2277/11

Abstract: Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters.

公开(公告)号：US20110135053A1

公开(公告)日：2011-06-09

申请号：US13058197

申请日：2009-08-11

Applicant: Nicolaas Jan Noordhoek ,  Jan Timmer

Inventor： Nicolaas Jan Noordhoek ,  Jan Timmer

IPC: A61B6/00

CPC classification number: A61B6/583 ,  A61B6/027

Abstract: The present invention refers to 3D rotational X-ray imaging systems for use in computed tomography (CT) and, more particularly, to a fast, accurate and mathematically robust calibration method for determining the effective center of rotation (I) in not perfectly isocentric 3D rotational C-arm systems and eliminating substantially circular ring artifacts (RA) which arise when using such a CT scanner system for acquiring a set of 2D projection images of an object of interest to be three-dimensionally reconstructed. For this purpose, a C-arm based rotational CT scanner comprising at least one radiation detector (D) having an X-radiation sensitive surface exposed to an X-ray beam emitted by at least one X-ray tube (S), each rotating along a non-ideal circular trajectory (TF, TCD) about an object of interest to be three-dimensionally reconstructed from a set of 2D projection images is used for providing geometrical calibration data by scanning a calibration phantom from a plurality of distinct projection directions and calculating, for each projection direction, the 3D positions of the X-ray tube's focal spot and the X-ray detector's center. For approximating the exact 3D position and angular direction of the axis of rotation about which the at least one X-ray tube and the at least one radiation detector rotate, a circular regression technique using a number of mathematically robust least squares fits is applied.

Abstract translation: 本发明涉及用于计算机断层摄影（CT）的3D旋转X射线成像系统，更具体地，涉及用于在不完全同心的3D中确定有效旋转中心（I）的快速，准确和数学上鲁棒的校准方法 旋转C形臂系统，并且消除了当使用这种CT扫描器系统获取要被三维重建的感兴趣对象的一组2D投影图像时出现的大致圆形的环形假象（RA）。 为此目的，一种基于C臂的旋转CT扫描仪，其包括至少一个辐射检测器（D），其具有暴露于由至少一个X射线管（S）发射的X射线束的X射线敏感表面，每个旋转 沿着从一组2D投影图像三维地重构的关于感兴趣对象的非理想圆弧轨迹（TF，TCD）用于通过从多个不同的投影方向扫描校准体模来提供几何校准数据，以及 对于每个投射方向，计算X射线管的焦斑和X射线检测器的中心的3D位置。 为了近似至少一个X射线管和至少一个辐射探测器旋转的旋转轴的精确3D位置和角度方向，应用使用多个数学鲁棒的最小二乘拟合的循环回归技术。