公开(公告)号：US08208708B2

公开(公告)日：2012-06-26

申请号：US12294626

申请日：2007-03-15

Applicant: Robert Johannes Frederik Homan ,  Drazenko Babic ,  Pieter Maria Mielekamp ,  Jan Timmer

Inventor： Robert Johannes Frederik Homan ,  Drazenko Babic ,  Pieter Maria Mielekamp ,  Jan Timmer

IPC: G06K9/00

CPC classification number: A61B90/36 ,  A61B6/4441 ,  A61B34/10 ,  A61B2018/2025 ,  A61B2034/107 ,  A61B2090/364 ,  A61B2090/366

Abstract: According to an exemplary embodiment a targeting method for targeting a first object from an entry point to a target point in an object (110) under examination is provided, wherein the method comprises selecting a two-dimensional image (301) of the object under examination depicting the entry point (305) and the target point (303) and determining a planned path (304) from the entry point to the target point, wherein the planned path has a first direction. Furthermore, the method comprises recording data representing a fluoroscopic image of the object under examination, wherein the fluoroscopic image is recorded under a second direction so that a normal of the image coincide with the first direction and determining whether the first object is on the determined planned path based on shape and/or position of the projection of the first object in the fluoroscopic image.

Abstract translation: 根据示例性实施例，提供了一种用于将第一对象从检查对象（110）中的入口点定位到目标点的目标方法，其中，所述方法包括选择被检查对象的二维图像（301） 描绘入口点（305）和目标点（303），并从入口点到目标点确定计划路径（304），其中计划路径具有第一方向。 此外，该方法包括记录表示所检查对象的透视图像的数据，其中在第二方向上记录荧光透视图像，使得图像的法线与第一方向一致并且确定第一对象是否在确定的计划 基于第一物体在透视图像中的投影的形状和/或位置的路径。

公开(公告)号：US20090310754A1

公开(公告)日：2009-12-17

申请号：US12374391

申请日：2007-07-10

Applicant: Jan Timmer ,  Peter George Van De Haar

Inventor： Jan Timmer ,  Peter George Van De Haar

IPC: G01D18/00

CPC classification number: G01D18/00 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/4291 ,  A61B6/5258 ,  A61B6/5282 ,  A61B6/583 ,  A61B6/585

Abstract: It is described a gain calibration for a two-dimensional X-ray detector (315), in which the gain coefficients for scattered radiation (307b) and direct radiation (307a) are measured or estimated separately. A weighed average may be applied on the appropriate scatter fraction. The scatter fraction depending gain calibration method produces less ring artifacts in X-ray images as compared to known gain calibration methods, which do not take into account the fraction of scattered radiation reaching the X-ray detector (315).

Abstract translation: 描述了用于二维X射线检测器（315）的增益校准，其中散射辐射（307b）和直接辐射（307a）的增益系数被分别测量或估计。 加权平均值可以应用于适当的分散分数。 与已知的增益校准方法相比，散射分数依赖性增益校准方法在X射线图像中产生较少的环形伪影，其不考虑到到达X射线检测器的散射辐射的分数（315）。

公开(公告)号：US20080192996A1

公开(公告)日：2008-08-14

申请号：US11817801

申请日：2006-03-09

Applicant: Jan Timmer ,  Robert Johannes Frederick Homan ,  Pieter Maria Mielekamp

Inventor： Jan Timmer ,  Robert Johannes Frederick Homan ,  Pieter Maria Mielekamp

IPC: G06K9/00

CPC classification number: A61B6/4441 ,  G06T7/35 ,  G06T2207/30004 ,  Y10S128/922

Abstract: Prior to an intervention, a 3D rotational scan is acquired (at block 10) in respect of a body volume and reconstructed. In addition, three-dimensional image data in respect of the body volume is acquired (at block 12) using another modality, such as computerised tomography (CT) or magnetic resonance (MR), reconstructed, and prepared for visualisation. During the actual intervention, live two-dimensional fluoroscopic images are acquired (at block 14), using the imaging system employed to acquire the 3D rotational scan, and processed for visualisation. The 2D image data is registered (at block 16) to the 3D rotational image data acquired and reconstructed in respect of the body volume of interest, and then a 3D-3D registration process is employed (at block 18) to register the 3D image data acquired in respect of the same body volume using, for example, CT or MR imaging systems to the 3D rotational image data, and a display module (20) is used to align the 2D fluoroscopic image and the 3D MR/CT image as a fused or composite image and display the image.

Abstract translation: 在干预之前，相对于身体体积获取3D重新扫描（在方框10）并重构。 此外，使用诸如计算机断层摄影（CT）或磁共振（MR）之类的另一种模式，获取关于体积的三维图像数据（方框12），并重建并准备用于可视化。 在实际干预过程中，使用用于获取3D旋转扫描的成像系统获取活体二维透视图像（在方框14），并进行可视化处理。 将2D图像数据（方框16）登记到相对于感兴趣的身体体积获取和重建的3D旋转图像数据，然后采用3D-3D注册处理（在框18处）以登记3D图像数据 使用例如CT或MR成像系统相对于3D旋转图像数据获得相同体积的体积，并且显示模块（20）用于将2D透视图像和3D MR / CT图像对准为融合 或合成图像并显示图像。

公开(公告)号：US06751286B2

公开(公告)日：2004-06-15

申请号：US10150053

申请日：2002-05-16

Applicant: Jan Timmer

Inventor： Jan Timmer

IPC: G01N2304

CPC classification number: G06T11/005

Abstract: A computed-tomography system comprises a data-processing system arranged to receive attenuation profiles for respective orientations. A lowest representative noise level of the individual attenuation profiles is determined. The attenuation profiles are filtered in dependence of said lowest representative noise level. In particular it is achieved that the filtered attenuation profiles have the lowest maximum noise level among the received attenuation profiles.

Abstract translation: 计算机断层摄影系统包括被布置为接收各个取向的衰减曲线的数据处理系统。 确定各个衰减曲线的最低代表性噪声水平。 根据所述最低代表性噪声电平对衰减曲线进行滤波。 特别地，实现了滤波的衰减分布在接收的衰减分布中具有最低的最大噪声电平。

公开(公告)号：US07912262B2

公开(公告)日：2011-03-22

申请号：US11817801

申请日：2006-03-09

Applicant: Jan Timmer ,  Robert Johannes Frederik Homan ,  Pieter Maria Mielekamp

Inventor： Jan Timmer ,  Robert Johannes Frederik Homan ,  Pieter Maria Mielekamp

IPC: G06K9/00

CPC classification number: A61B6/4441 ,  G06T7/35 ,  G06T2207/30004 ,  Y10S128/922

Abstract: Prior to an intervention, a 3D rotational scan is acquired (at block 10) in respect of a body volume and reconstructed. In addition, three-dimensional image data in respect of the body volume is acquired (at block 12) using another modality, such as computerised tomography (CT) or magnetic resonance (MR), reconstructed, and prepared for visualisation. During the actual intervention, live two-dimensional fluoroscopic images are acquired (at block 14), using the imaging system employed to acquire the 3D rotational scan, and processed for visualisation. The 2D image data is registered (at block 16) to the 3D rotational image data acquired and reconstructed in respect of the body volume of interest, and then a 3D-3D registration process is employed (at block 18) to register the 3D image data acquired in respect of the same body volume using, for example, CT or MR imaging systems to the 3D rotational image data, and a display module (20) is used to align the 2D fluoroscopic image and the 3D MR/CT image as a fused or composite image and display the image.

Abstract translation: 在干预之前，相对于身体体积获取3D重新扫描（在方框10）并重构。 此外，使用诸如计算机断层摄影（CT）或磁共振（MR）之类的另一种模式，获取关于体积的三维图像数据（方框12），并重建并准备用于可视化。 在实际干预过程中，使用用于获取3D旋转扫描的成像系统获取活体二维透视图像（在方框14），并进行可视化处理。 将2D图像数据（方框16）登记到相对于感兴趣的身体体积获取和重建的3D旋转图像数据，然后采用3D-3D注册处理（在框18处）以登记3D图像数据 使用例如CT或MR成像系统相对于3D旋转图像数据获得相同体积的体积，并且显示模块（20）用于将2D透视图像和3D MR / CT图像对准为融合 或合成图像并显示图像。

公开(公告)号：US07340027B2

公开(公告)日：2008-03-04

申请号：US10564571

申请日：2004-07-16

Applicant: Jan Timmer

Inventor： Jan Timmer

IPC: A61B6/03

CPC classification number: G06T11/005 ,  G06T5/005 ,  G06T7/13 ,  G06T2207/10081 ,  G06T2207/20192 ,  G06T2207/30004 ,  Y10S378/901

Abstract: An artifact correcting image reconstruction apparatus includes a reconstruction processor (70) that reconstructs acquired projection data (60) into an uncorrected reconstructed image (74). A classifying processor (78) classifies pixels of the uncorrected reconstructed image (74) at least into high, medium, and low density pixel classes. A pixel replacement processor (88) replaces pixels of the uncorrected reconstructed image (74) that are of the high density and low density classes with pixel values of the low density pixel class to generate a synthetic image (90). A forward projecting processor (94) forward projects the synthetic image (90) to generate synthetic projection data (96). A projection replacement processor (100, 110) replaces acquired projection data (60) contributing to the pixels of the high density class with corresponding synthetic projection data (96) to generate corrected projection data (112). The reconstruction processor (70) reconstructs the corrected projection data (112) into a corrected reconstructed image (120).

Abstract translation: 伪像校正图像重建装置包括将获取的投影数据（60）重建成未校正的重建图像（74）的重建处理器（70）。 分类处理器（78）将未校正的重建图像（74）的像素至少分类为高，中和低密度像素类。 像素置换处理器（88）用低密度像素类别的像素值代替具有高密度和低密度等级的未校正重建图像（74）的像素，以生成合成图像（90）。 前向投影处理器（94）向前投影合成图像（90）以产生合成投影数据（96）。 投影替换处理器（100,110）用对应的合成投影数据（96）代替对高密度类别的像素有贡献的所获取的投影数据（60），以产生校正投影数据（112）。 重建处理器（70）将经校正的投影数据（112）重建为校正后的重建图像（120）。

公开(公告)号：US06430432B1

公开(公告)日：2002-08-06

申请号：US09469457

申请日：1999-12-21

Applicant: Jantje E. Wilting ,  Jan Timmer

Inventor： Jantje E. Wilting ,  Jan Timmer

IPC: A61B505

CPC classification number: G06T7/60 ,  G06T2207/10116 ,  Y10S128/916

Abstract: The size of a detail of an object is derived from a data set of data values relating to the object. The data set assigns the data values to positions in a multidimensional space. A direction is selected in the multidimensional space. The spatial resolution of the data set is higher in the selected direction as compared to the spatial resolution in other directions. The size of the detail is derived from data values in the selected direction. The selected direction can extend along the line of intersection which intersects a scanning plane in which the data values are acquired and a transverse plane extending at right angles to the longitudinal axis of the detail. The data values can be acquired an X-ray computed tomography imaging system, a magnetic resonsance imaging system, or a 3D ultrasound imaging system.

Abstract translation: 来自与对象相关的数据值的数据集的对象的细节的大小。 数据集将数据值分配给多维空间中的位置。 在多维空间中选择方向。 与其他方向上的空间分辨率相比，数据集的空间分辨率在所选方向上更高。 细节的大小从所选方向的数据值导出。 所选择的方向可以沿着与其中获取数据值的扫描平面相交的交叉线和与细节的纵向轴线成直角延伸的横向平面延伸。 可以获取X射线计算机断层摄影成像系统，磁共振成像系统或3D超声成像系统的数据值。

公开(公告)号：US06324248B1

公开(公告)日：2001-11-27

申请号：US09684194

申请日：2000-10-06

Applicant: Jan Timmer ,  Jantje Edith Wilting

Inventor： Jan Timmer ,  Jantje Edith Wilting

IPC: A61B600

CPC classification number: G06T11/006 ,  A61B6/4447 ,  G06T2211/421

Abstract: A cross-sectional distribution along a cutting plane is derived from an object data set of data values. The cross-sectional distribution comprises density values. The density values are calculated from data values of the object data set in positions outside the cutting plane. The object data set represents an object to be examined and is, for example, acquired by way of volumetric computed tomography or magnetic resonance imaging. For example, the density values of the cross-sectional distribution are calculated by local (slab) MIP or mIP or by interpolation.

Abstract translation: 沿着切割平面的横截面分布从数据值的对象数据集导出。 横截面分布包括密度值。 从在切割平面外的位置设定的对象数据的数据值计算密度值。 对象数据集表示要检查的对象，例如通过体积计算机断层摄影或磁共振成像获取。 例如，通过局部（平板）MIP或mIP或插值计算横截面分布的密度值。

公开(公告)号：US6094468A

公开(公告)日：2000-07-25

申请号：US103735

申请日：1998-06-24

Applicant: Jantje E. Wilting ,  Jan Timmer ,  Fransisca M. C. De Brouwer

Inventor： Jantje E. Wilting ,  Jan Timmer ,  Fransisca M. C. De Brouwer

IPC: A61B6/00 ,  A61B6/03 ,  H05G1/30 ,  H05G1/46

CPC classification number: A61B6/032 ,  H05G1/46 ,  A61B6/4028

Abstract: A computer tomography device includes an X-ray source (1) and an X-ray detection system (3) for forming a number of density profiles of an object to be radiologically examined. A reconstruction unit (4) derives an image signal from the density profiles. A control system (20) adjusts the X-ray source (1) on the basis of a density value of the object and the control system is arranged to adjust the X-ray source on the basis of a part of the object to be examined. The control system is also arranged to adjust the X-ray source on the basis of a reference adjustment of the X-ray source. The reference adjustment is dependent on the part of the object to be examined.

Abstract translation: 计算机断层摄影装置包括用于形成要放射学检查的对象的多个密度分布的X射线源（1）和X射线检测系统（3）。 重建单元（4）从密度分布中导出图像信号。 控制系统（20）基于物体的密度值来调整X射线源（1），并且控制系统被布置为基于待检查对象的一部分来调整X射线源 。 控制系统还被设置为基于X射线源的参考调整来调整X射线源。 参考调整取决于被检查对象的部分。

公开(公告)号：US5060246A

公开(公告)日：1991-10-22

申请号：US354005

申请日：1989-05-19

Applicant: Willem P. Van Der Brug ,  Jan Timmer ,  Petrus N. J. Vis

Inventor： Willem P. Van Der Brug ,  Jan Timmer ,  Petrus N. J. Vis

IPC: A61B6/03 ,  H05G1/52

CPC classification number: A61B6/032 ,  A61B6/4021

Abstract: A computer tomography system includes an X-ray tube having an elongate anode across which a beam spot can be displaced, a scanogram being formed by correctly shifting the profiles measured in the various source positions with respect to one another, followed by superposition. Parts of the object which are situated in a selected layer are thus emphasized in an image, parts of the object which are situated outside the selected layer being blurred. When a point of interest in the object is determined by observation of the scanogram, the same apparatus is used to produce a tomography slice image transverse the scanogram image. An important additional advantage consists in that the permissible power to be applied to the X-ray source may be higher. Furthermore, a scanogram thus obtained is not necessarily disturbed by the failure of one or more detectors.