-
公开(公告)号：US09650395B2
公开(公告)日：2017-05-16
申请号：US14241372
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： A61K31/4427 , A61K31/4412 , A61K45/06 , A61K31/5383 , C07D515/04 , A61K31/5377 , A61K31/4439 , C07D213/80 , C07D401/10 , C07D487/08 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/496
CPC分类号： C07D515/04 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D213/80 , C07D401/10 , C07D487/08 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
-
公开(公告)号：US09409905B2
公开(公告)日：2016-08-09
申请号：US14241506
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , John David Baird , Guangming Chen , Olya Ginzburg , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Matthew G. Woll , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , John David Baird , Guangming Chen , Olya Ginzburg , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Matthew G. Woll , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D401/14 , C07D413/04 , C07D471/04 , C07D405/14 , C07D401/04 , A61K31/4709 , A61K31/5377 , A61K31/4439 , A61K45/06 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
摘要翻译： 本说明书涉及其化合物及其形式及其药物组合物及其用于治疗或改善由野生型和多药耐药革兰氏阴性和革兰氏阳性病原体引起的细菌感染的方法。
-
3.发明授权Preparation of recombinant ubiquitin cross-reactive protein (UCRP) with improved bioactivity 失效具有改善的生物活性的重组泛素交叉反应蛋白（UCRP）的制备
公开(公告)号：US5714347A
公开(公告)日：1998-02-03
申请号：US577640
申请日：1995-12-22
申请人： Arthur L. Haas , Jana Narasimhan
发明人： Arthur L. Haas , Jana Narasimhan
CPC分类号： C07K14/00
摘要： A method of preparing recombinant ubiquitin cross-reactive protein (UCRP) is disclosed. In one embodiment, the method comprises the step of purifying UCRP from a host cell in the presence of a cobalt or Group IIb metal, wherein the cobalt or Group IIb metal prevents proteolytic inactivation of UCRP occurring by cleavage of the UCRP carboxyl terminal glycine dipeptide. In another embodiment the method comprises purifying UCRP comprising an additional arginine or lysine residue at the carboxy terminal. A preparation of UCRP with an additional arginine residue at the carboxy terminus is also disclosed.
摘要翻译： 公开了一种制备重组泛素交叉反应蛋白（UCRP）的方法。 在一个实施方案中，所述方法包括在钴或IIb族金属存在下从宿主细胞中纯化UCRP的步骤，其中所述钴或IIb族金属通过UCRP羧基末端甘氨酸二肽的切割来防止UCRP的蛋白水解失活。 在另一个实施方案中，该方法包括在羧基末端纯化包含另外的精氨酸或赖氨酸残基的UCRP。 还公开了在羧基末端具有另外的精氨酸残基的UCRP的制备。
-
公开(公告)号：US20150080362A1
公开(公告)日：2015-03-19
申请号：US14241372
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D515/04 , A61K31/4412 , C07D401/10 , A61K45/06 , A61K31/5377 , A61K31/4439 , C07D487/08 , A61K31/5383 , C07D213/80 , A61K31/4427
CPC分类号： C07D515/04 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D213/80 , C07D401/10 , C07D487/08 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
-
-
-
搜索结果
4 条记录 (耗时 0.033 秒)
