-
1.发明授权公开(公告)号：US08299105B2
公开(公告)日：2012-10-30
申请号：US13427932
申请日：2012-03-23
Applicant: Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
Inventor： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
IPC: A61K31/4245
CPC classification number: C07D285/14 , C07D413/02
Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
Abstract translation: 公开了新的1,2,4-恶二唑苯甲酸化合物，使用方法和包含1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
-
2.发明授权Pharmaceutical compositions of 1,2,4-oxadiazole benzoic acid and their use for the treatment of disease 有权1,2,4-恶二唑苯甲酸的药物组合物及其用于治疗疾病的用途公开(公告)号：US08227494B2
公开(公告)日：2012-07-24
申请号：US12719443
申请日：2010-03-08
Applicant: Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
Inventor： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
IPC: C07D271/06 , A61K31/4245
CPC classification number: A61K31/4245 , A61K9/0053 , A61K9/12 , A61K9/48 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/655 , A61K45/06 , A61P27/02 , C07D271/06 , C07D271/12 , C07D285/14 , C07D413/02 , C07D413/04 , C07D413/10
Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
Abstract translation: 公开了新的1,2,4-恶二唑苯甲酸化合物，使用方法和包含1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
-
公开(公告)号：US08163782B2
公开(公告)日：2012-04-24
申请号：US13212221
申请日：2011-08-18
Applicant: Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
Inventor： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
IPC: A61K31/4245 , C07D271/06
CPC classification number: A61K31/4245 , A61K9/0053 , A61K9/12 , A61K9/48 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/655 , A61K45/06 , A61P27/02 , C07D271/06 , C07D271/12 , C07D285/14 , C07D413/02 , C07D413/04 , C07D413/10
Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
Abstract translation: 公开了新的1,2,4-恶二唑苯甲酸化合物，使用方法和包含1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
-
4.发明授权Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease 有权脲基取代的苯甲酸化合物及其用于无意义抑制和治疗疾病的用途公开(公告)号：US07902241B2
公开(公告)日：2011-03-08
申请号：US12140641
申请日：2008-06-17
Applicant: Richard G. Wilde , James J. Takasugi , Seongwoo Hwang , Ellen M. Welch , Guangming Chen
Inventor： Richard G. Wilde , James J. Takasugi , Seongwoo Hwang , Ellen M. Welch , Guangming Chen
IPC: A61K31/425 , C07D233/00
CPC classification number: C07D285/16 , A61K31/17 , A61K31/4166 , A61K31/4172 , A61K31/4196 , A61K31/421 , A61K31/426 , C07C275/42 , C07D233/32 , C07D233/42 , C07D233/72 , C07D401/04 , C07D401/10 , C07D405/04 , C07D405/06 , C07D409/04
Abstract: The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
Abstract translation: 本发明包括脲基取代的苯甲酸化合物，包含该化合物的组合物和通过施用这些化合物或组合物来治疗或预防与无义突变mRNA相关的疾病的方法。
-
5.发明申请METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH 有权从具有非扩散性突变的DNA生产功能性蛋白质的方法和与之相关的疾病的治疗方法公开(公告)号：US20110046136A1
公开(公告)日：2011-02-24
申请号：US12294952
申请日：2007-03-29
Applicant: Neil G. Almstead , Guangming Chen , Hirawat Samit , Peter Seongwoo Hwang , Gary M. Karp , Langdon Miller , Young-Choon Moon , Hongyu Ren , James J. Takasugi , Ellen M. Welch , Richard G. Wilde , Paul Kennedy
Inventor： Neil G. Almstead , Guangming Chen , Hirawat Samit , Peter Seongwoo Hwang , Gary M. Karp , Langdon Miller , Young-Choon Moon , Hongyu Ren , James J. Takasugi , Ellen M. Welch , Richard G. Wilde , Paul Kennedy
IPC: A61K31/4245 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4709 , A61K31/4439 , A61K31/519 , A61K31/498 , A61K31/53 , A61K31/506 , A61K31/497 , A61K31/501 , A61K31/433 , A61K31/421 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/42 , A61K31/4164 , A61K31/34 , A61K31/381 , A61K31/4196 , A61P21/00 , A61P11/00 , A61P7/00 , A61P25/00 , A61P13/12 , A61P27/02
CPC classification number: A61K31/4245 , A61K31/00 , A61K31/40 , A61K31/41 , A61K31/4162 , A61K31/44 , A61K31/46
Abstract: The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.
Abstract translation: 本发明涉及由包含无义突变的核酸序列编码的功能性蛋白质。 本发明还涉及用于产生由包含无义突变的核酸序列编码的功能性蛋白质的方法以及用于预防，管理和/或治疗与基因中的无义突变有关的疾病的这些蛋白质的用途。
-
Patent Agency Ranking
公开(公告)号：US07868037B2
公开(公告)日：2011-01-11
申请号：US11331180
申请日：2006-01-13
Applicant: Gary Mitchell Karp , Peter Seongwoo Hwang , James Jan Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Allan Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell
Inventor： Gary Mitchell Karp , Peter Seongwoo Hwang , James Jan Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Allan Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell
IPC: C07D209/10 , A61K31/404
CPC classification number: C07D403/12 , C07D209/14 , C07D209/42 , C07D401/12 , C07D403/10 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
Abstract translation: 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
-
公开(公告)号：US07772271B2
公开(公告)日：2010-08-10
申请号：US11653448
申请日：2007-01-16
Applicant: Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
Inventor： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC: C07D209/10 , A61K31/404
CPC classification number: C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
-
8.发明申请PHARMACEUTICAL COMPOSITIONS OF 1,2,4-OXADIAZOLE BENZOIC ACID AND THEIR USE FOR THE TREATMENT OF DISEASE 有权1,2,4-氧代噻唑酸的药物组合物及其用于治疗疾病的用途公开(公告)号：US20100168109A1
公开(公告)日：2010-07-01
申请号：US12719443
申请日：2010-03-08
Applicant: Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
Inventor： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
IPC: A61K31/5377 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61P25/00 , A61P43/00
CPC classification number: A61K31/4245 , A61K9/0053 , A61K9/12 , A61K9/48 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/655 , A61K45/06 , A61P27/02 , C07D271/06 , C07D271/12 , C07D285/14 , C07D413/02 , C07D413/04 , C07D413/10
Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
Abstract translation: 公开了新的1,2,4-恶二唑苯甲酸化合物，使用方法和包含1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
-
公开(公告)号：US20090253699A1
公开(公告)日：2009-10-08
申请号：US11577191
申请日：2005-10-13
Applicant: Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
Inventor： Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
IPC: A61K31/5377 , A61K31/4245 , C07D271/10 , C12N5/00 , C07D413/02 , A61K31/433 , C07D285/12 , A61K31/421 , C07D263/30 , A61K31/415 , C07D231/10 , A61K31/426 , C07D277/20 , C07D307/02 , A61K31/34 , A61P37/06 , A61P7/00 , A61P25/00 , A61P9/00 , A61P29/00
CPC classification number: C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
Abstract translation: 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
-
公开(公告)号：US20070299068A1
公开(公告)日：2007-12-27
申请号：US11653448
申请日：2007-01-16
Applicant: Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
Inventor： Gary Karp , Peter Hwang , James Takasugi , Hongyu Ren , Richard Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Campbell
IPC: A61K31/404 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/5377 , A61P31/12 , C07D209/10 , C07D271/06 , C07D401/10 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/10
CPC classification number: C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
-
-
-
-
-
-
-
-
-
Search Results
62
records
(took 0.042 seconds)
