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公开(公告)号：US20150080362A1
公开(公告)日：2015-03-19
申请号：US14241372
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D515/04 , A61K31/4412 , C07D401/10 , A61K45/06 , A61K31/5377 , A61K31/4439 , C07D487/08 , A61K31/5383 , C07D213/80 , A61K31/4427
CPC分类号： C07D515/04 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D213/80 , C07D401/10 , C07D487/08 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
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公开(公告)号：US09650395B2
公开(公告)日：2017-05-16
申请号：US14241372
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： A61K31/4427 , A61K31/4412 , A61K45/06 , A61K31/5383 , C07D515/04 , A61K31/5377 , A61K31/4439 , C07D213/80 , C07D401/10 , C07D487/08 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/496
CPC分类号： C07D515/04 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D213/80 , C07D401/10 , C07D487/08 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
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公开(公告)号：US09409905B2
公开(公告)日：2016-08-09
申请号：US14241506
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , John David Baird , Guangming Chen , Olya Ginzburg , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Matthew G. Woll , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , John David Baird , Guangming Chen , Olya Ginzburg , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Matthew G. Woll , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D401/14 , C07D413/04 , C07D471/04 , C07D405/14 , C07D401/04 , A61K31/4709 , A61K31/5377 , A61K31/4439 , A61K45/06 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
摘要翻译： 本说明书涉及其化合物及其形式及其药物组合物及其用于治疗或改善由野生型和多药耐药革兰氏阴性和革兰氏阳性病原体引起的细菌感染的方法。
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公开(公告)号：US07772271B2
公开(公告)日：2010-08-10
申请号：US11653448
申请日：2007-01-16
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20110268698A1
公开(公告)日：2011-11-03
申请号：US13158692
申请日：2011-06-13
申请人： Gary M. KARP , Peter Seongwoo HWANG , James J. TAKASUGI , Hongyu REN , Richard Gerald WILDE , Anthony A. TURPOFF , Alexander AREFOLOV , Guangming CHEN , Jeffrey Allen CAMPBELL , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary M. KARP , Peter Seongwoo HWANG , James J. TAKASUGI , Hongyu REN , Richard Gerald WILDE , Anthony A. TURPOFF , Alexander AREFOLOV , Guangming CHEN , Jeffrey Allen CAMPBELL , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K38/21
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IBES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IBES活性的方法。
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公开(公告)号：US07781478B2
公开(公告)日：2010-08-24
申请号：US11653450
申请日：2007-01-16
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US07973069B2
公开(公告)日：2011-07-05
申请号：US12814755
申请日：2010-06-14
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20100305100A1
公开(公告)日：2010-12-02
申请号：US12828597
申请日：2010-07-01
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/55 , C07D209/04 , C07D417/06 , C07D405/12 , C07D271/10 , C07D403/04 , C07D263/30 , C07D401/12 , C07D239/10 , C07D215/00 , C07D223/16 , A61K31/405 , A61K31/40 , A61K31/4155 , A61K31/4245 , A61K31/427 , A61K31/42 , A61K31/4439 , A61K31/497 , A61K31/4725 , A61P31/14 , A61P31/12
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20100292187A1
公开(公告)日：2010-11-18
申请号：US12814755
申请日：2010-06-14
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey A. Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey A. Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/675 , A61K31/541 , A61K31/53 , A61K31/497 , A61K31/506 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4196 , A61K31/4155 , A61K31/407 , A61K31/404 , C07D417/12 , C07D413/12 , C07D401/12 , C07D413/04 , C07D417/10 , C07D413/10 , C07F9/572 , C07D491/14 , C07D403/10 , C07D209/14 , C07D403/12 , C07D407/12 , C07D417/04 , C07D403/04 , C07D401/04 , A61P31/12
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US20120135999A1
公开(公告)日：2012-05-31
申请号：US13259283
申请日：2010-04-05
申请人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
发明人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： A61K31/501 , C07D487/04 , C12N7/06 , A61K31/437 , A61P31/14 , A61K31/519 , A61K31/497 , A61P31/12 , A61P31/18 , A61P31/22 , C07D471/04 , A61K31/506
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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