公开(公告)号：US20140294725A1

公开(公告)日：2014-10-02

申请号：US14131420

申请日：2012-07-06

申请人： Gabriela Chiosis ,  Nagavarakishore Pillarsetty ,  Jason S. Lewis ,  Steven M. Larson ,  Tony Taldone ,  Mary L. Alpaugh ,  Erica M. Gomes

发明人： Gabriela Chiosis ,  Nagavarakishore Pillarsetty ,  Jason S. Lewis ,  Steven M. Larson ,  Tony Taldone ,  Mary L. Alpaugh ,  Erica M. Gomes

IPC分类号： A61K51/04 ,  G01N33/574

CPC分类号： A61K51/0459 ,  A61K31/52 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/5044 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57426 ,  G01N2500/04 ,  G01N2800/52

摘要： The invention concerns various methods of using labeled HSP90 inhibitors to improve treatment of cancer patients with HSP90 inhibitors, including ex vivo and in vivo methods for determining whether a tumor will likely respond to therapy with an HSP90 inhibitor. The disclosure provides a method for determining whether a tumor will likely respond to therapy with an HSP90 inhibitor which comprises the following steps: (a) contacting the tumor or a sample containing cells from the tumor with a detectably labeled HSP90 inhibitor which binds preferentially to a tumor-specific form of HSP90; (b) measuring the amount of labeled HSP90 inhibitor bound to the tumor or the tumor cells in the sample; and (c) comparing the amount of labeled HSP90 inhibitor bound to the tumor or the tumor cells in the sample measured in step (b) to the amount of labeled-HSP90 inhibitor bound to a reference.

摘要翻译： 本发明涉及使用标记的HSP90抑制剂改善用HSP90抑制剂治疗癌症患者的各种方法，包括用于确定肿瘤是否可能对HSP90抑制剂治疗有反应的离体和体内方法。 本公开提供了一种用于确定肿瘤是否可能响应于HSP90抑制剂治疗的方法，该方法包括以下步骤：（a）使来自肿瘤的肿瘤或含有细胞的样品与优先结合于肿瘤的可检测标记的HSP90抑制剂接触 肿瘤特异性形式的HSP90; （b）测量与样品中的肿瘤或肿瘤细胞结合的标记的HSP90抑制剂的量; 和（c）将在步骤（b）中测量的样品中与肿瘤或肿瘤细胞结合的标记HSP90抑制剂的量与结合参考物的标记的HSP90抑制剂的量进行比较。

公开(公告)号：US5765337A

公开(公告)日：1998-06-16

申请号：US652009

申请日：1996-05-23

申请人： Lloyd E. Lodewegen ,  David J. Seavey ,  Darrin J. Harder ,  David R. Brownson ,  Jason S. Lewis

发明人： Lloyd E. Lodewegen ,  David J. Seavey ,  Darrin J. Harder ,  David R. Brownson ,  Jason S. Lewis

IPC分类号： B65B5/10 ,  B65B25/06 ,  B65B57/00

CPC分类号： B65B25/065 ,  B65B5/10

摘要： A packaging system includes a stacking apparatus which utilizes a supplemental stacking member on a transfer mechanism for receiving at least one article from a conveying mechanism while the transfer mechanism is transferring a stack, such that a new stack is begun prior to completing the transfer of the first stack. This permits a substantially constant supply of articles to be provided continuously to the stacking apparatus without having to interrupt or slow down the flow of articles to the apparatus. The packaging system also includes a boxing apparatus which relies on pneumatically-actuated positioning mechanisms to move stacks of articles to discrete positions within boxes. Both the position and the velocity of the pneumatic mechanisms are utilized as feedback to provide increased speed without compromising positioning accuracy.

摘要翻译： 一种包装系统包括：堆叠装置，其在传送机构上使用补充堆积构件，用于在传送机构传送堆栈的同时从传送机构接收至少一个物品，使得在完成传送之前开始新的堆叠 第一堆 这允许将物品的大量恒定供应连续地提供给堆垛装置，而不必中断或减缓物品流入设备。 包装系统还包括依靠气动致动的定位机构将物品堆叠移动到箱内离散位置的拳击装置。 利用气动机构的位置和速度作为反馈来提高速度，而不会影响定位精度。