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    USES OF LABELED HSP90 INHIBITORS
    1.
    发明申请
    USES OF LABELED HSP90 INHIBITORS 审中-公开
    标签HSP90抑制剂的使用

    公开(公告)号：US20140294725A1

    公开(公告)日：2014-10-02

    申请号：US14131420

    申请日：2012-07-06

    申请人： Gabriela Chiosis ,  Nagavarakishore Pillarsetty ,  Jason S. Lewis ,  Steven M. Larson ,  Tony Taldone ,  Mary L. Alpaugh ,  Erica M. Gomes

    发明人： Gabriela Chiosis ,  Nagavarakishore Pillarsetty ,  Jason S. Lewis ,  Steven M. Larson ,  Tony Taldone ,  Mary L. Alpaugh ,  Erica M. Gomes

    IPC分类号： A61K51/04 ,  G01N33/574

    CPC分类号： A61K51/0459 ,  A61K31/52 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/5044 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57426 ,  G01N2500/04 ,  G01N2800/52

    摘要： The invention concerns various methods of using labeled HSP90 inhibitors to improve treatment of cancer patients with HSP90 inhibitors, including ex vivo and in vivo methods for determining whether a tumor will likely respond to therapy with an HSP90 inhibitor. The disclosure provides a method for determining whether a tumor will likely respond to therapy with an HSP90 inhibitor which comprises the following steps: (a) contacting the tumor or a sample containing cells from the tumor with a detectably labeled HSP90 inhibitor which binds preferentially to a tumor-specific form of HSP90; (b) measuring the amount of labeled HSP90 inhibitor bound to the tumor or the tumor cells in the sample; and (c) comparing the amount of labeled HSP90 inhibitor bound to the tumor or the tumor cells in the sample measured in step (b) to the amount of labeled-HSP90 inhibitor bound to a reference.

    摘要翻译： 本发明涉及使用标记的HSP90抑制剂改善用HSP90抑制剂治疗癌症患者的各种方法，包括用于确定肿瘤是否可能对HSP90抑制剂治疗有反应的离体和体内方法。 本公开提供了一种用于确定肿瘤是否可能响应于HSP90抑制剂治疗的方法，该方法包括以下步骤：（a）使来自肿瘤的肿瘤或含有细胞的样品与优先结合于肿瘤的可检测标记的HSP90抑制剂接触 肿瘤特异性形式的HSP90; （b）测量与样品中的肿瘤或肿瘤细胞结合的标记的HSP90抑制剂的量; 和（c）将在步骤（b）中测量的样品中与肿瘤或肿瘤细胞结合的标记HSP90抑制剂的量与结合参考物的标记的HSP90抑制剂的量进行比较。