公开(公告)号：US20110111021A1

公开(公告)日：2011-05-12

申请号：US12918993

申请日：2009-02-23

申请人： Sung Wuk Kim ,  Sung Soo Jun ,  Young Gwan Jo ,  Ja Seong Koo ,  Jaw Woon Son ,  Jin Wook Kim

发明人： Sung Wuk Kim ,  Sung Soo Jun ,  Young Gwan Jo ,  Ja Seong Koo ,  Jaw Woon Son ,  Jin Wook Kim

IPC分类号： A61K9/52 ,  A61K31/40 ,  A61K31/351 ,  A61K31/47 ,  A61K31/505 ,  A61K31/404 ,  A61K31/22 ,  A61K31/4164 ,  A61K31/5375 ,  A61K38/05 ,  A61K31/497 ,  A61K9/00 ,  A61K9/24 ,  A61K9/14 ,  A61P3/06

CPC分类号： A61K9/209 ,  A61K9/0004 ,  A61K31/165 ,  A61K31/41

摘要： The present invention provides a pharmaceutical preparation including a compartment containing a renin inhibitor as a pharmacologically active ingredient, and a compartment containing an HMG-CoA reductase inhibitor as a pharmacologically active ingredient, wherein one compartment is a prior-release compartment and the other compartment is a delayed-release compartment. The combination preparation of the present invention can deliver a renin inhibitor and an HMG-CoA reductase inhibitor with a time interval at a specific speed, thus reducing undesirable side-effects, improving the drug efficacy and promoting the patient compliance. Further, the pharmaceutical preparation of the present invention has pharmacological, clinical, scientific and economical advantages in the prevention or treatment of metabolic syndromes, cardiovascular diseases, renal diseases and the like, as compared with the complex drug regimens in which medicament ingredients are taken individually or simultaneously.

摘要翻译： 本发明提供一种药物制剂，其包含含有作为药理活性成分的肾素抑制剂的隔室，以及含有作为药理活性成分的HMG-CoA还原酶抑制剂的隔室，其中一个隔室为先前释放室，另一隔室为 延迟释放室。 本发明的组合制剂可以以特定速度的时间间隔递送肾素抑制剂和HMG-CoA还原酶抑制剂，从而减少不期望的副作用，改善药物功效并促进患者依从性。 此外，与复合药物方案相比，本发明的药物制剂在预防或治疗代谢综合征，心血管疾病，肾脏疾病等方面具有药理，临床，科学和经济优势，其中药物成分单独服用 或同时。