公开(公告)号：US20070202132A1

公开(公告)日：2007-08-30

申请号：US11637637

申请日：2006-12-12

申请人： Jay Morgenstern ,  Christine Bizinkauskas ,  Andrzej Konieczny ,  Andrew Brauer

发明人： Jay Morgenstern ,  Christine Bizinkauskas ,  Andrzej Konieczny ,  Andrew Brauer

IPC分类号： A61K39/35 ,  A61P37/08 ,  C07H21/04 ,  C07K14/46 ,  C12N1/00 ,  C12N15/63 ,  C12N5/04 ,  C12N5/06 ,  C12N5/08 ,  C12N5/10 ,  C12P21/00 ,  G01N33/563

CPC分类号： G01N33/6893 ,  A61K38/00 ,  A61K39/00 ,  C07K14/46 ,  C07K14/47 ,  G01N2800/24

摘要： Isolated nucleic acids encoding allergens of Canis familiaris, Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of petides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.

摘要翻译： 编码Canis familiaris，Can f I或Can f II的过敏原的分离的核酸被公开。 还描述了编码具有Can f I活性和约19,200道尔顿的预测分子量的肽的cDNA。 还公开了编码具有Can f II活性和预测分子量约18,200道尔顿的肽的cDNA。 核酸可以用作探针以检测样品中Can f I或Can f II核酸的存在，或用于重组生产具有Can f I或Can f II活性的化合物。 具有Can f I或Can f II活性的肽可用于适用于药物施用的组合物或诊断对狗皮的敏感性的方法。

公开(公告)号：US20060057641A1

公开(公告)日：2006-03-16

申请号：US11202960

申请日：2005-08-12

申请人： Jay Morgenstern ,  Christine Bizinkauskas ,  Andrzej Konieczny ,  Andrew Brauer

发明人： Jay Morgenstern ,  Christine Bizinkauskas ,  Andrzej Konieczny ,  Andrew Brauer

IPC分类号： G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/47 ,  C07K16/18

CPC分类号： G01N33/6893 ,  A61K38/00 ,  A61K39/00 ,  C07K14/46 ,  C07K14/47 ,  G01N2800/24

摘要： Isolated nucleic acids encoding allergens of Canis familiaris, Canf I or Can f II. are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of petides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.

摘要翻译： 编码Canis familiaris，Canf I或Can f II的过敏原的分离的核酸。 被披露。 还描述了编码具有Can f I活性和约19,200道尔顿的预测分子量的肽的cDNA。 还公开了编码具有Can f II活性和预测分子量约18,200道尔顿的肽的cDNA。 核酸可以用作探针以检测样品中Can f I或Can f II核酸的存在，或用于重组生产具有Can f I或Can f II活性的化合物。 具有Can f I或Can f II活性的肽可用于适用于药物施用的组合物或诊断对狗皮的敏感性的方法。