公开(公告)号：US20110218593A1

公开(公告)日：2011-09-08

申请号：US13061305

申请日：2009-09-03

申请人： Jay Rubinstein ,  William Harrison

发明人： Jay Rubinstein ,  William Harrison

IPC分类号： A61F11/04

CPC分类号： A61N1/361 ,  A61N1/0541 ,  A61N1/36036

摘要： Provided herein are systems, devices and methods for stimulation of the cochlea that are sufficient to mimic or replace the spontaneous background neural activity of the cochlea thereby reducing or eliminating tinnitus.

摘要翻译： 本文提供了用于刺激耳蜗的系统，装置和方法，其足以模拟或替代耳蜗的自发背景神经活动，从而减少或消除耳鸣。

公开(公告)号：US20120226187A1

公开(公告)日：2012-09-06

申请号：US13375196

申请日：2010-05-28

申请人： Steven Bierer ,  Albert Fuchs ,  Leo Ling ,  Kaibao Nie ,  James Phillips ,  Jay Rubinstein

发明人： Steven Bierer ,  Albert Fuchs ,  Leo Ling ,  Kaibao Nie ,  James Phillips ,  Jay Rubinstein

IPC分类号： A61B5/053 ,  A61F11/04 ,  A61N1/36

CPC分类号： A61B5/04001 ,  A61B5/4023 ,  A61B5/4047 ,  A61B5/7217 ,  A61B5/743 ,  A61N1/0526 ,  A61N1/0551 ,  A61N1/36036 ,  A61N1/36178 ,  A61N1/37247

摘要： A vestibular implant comprising a stimulation unit to generate electric stimuli and deliver to electrode arrays is disclosed. The stimulation unit generates electric stimuli in response to a user input or continuously generates electrical stimuli. The electrode arrays comprise electrodes and are adapted for placement within a semicircular canal of an ear. The electric stimuli is delivered from the stimulation unit to the electrode so that the electrodes apply electric stimuli. A predetermined electric stimulus is applied to restore spontaneous vestibular activity during a Meniere's attack. A continuous, unmodulated electric stimulus is applied to suppress the symptoms of unilateral loss of vestibular function. Additionally, the electrodes record electrically evoked compound action potentials (eCAP). An appropriate location for the placement of the electrode array is determined based on the recorded eCAP.

摘要翻译： 公开了一种包括产生电刺激并传递到电极阵列的刺激单元的前庭植入物。 刺激单元响应于用户输入产生电刺激或连续地产生电刺激。 电极阵列包括电极并且适于放置在耳朵的半圆形管内。 电刺激从刺激单元传递到电极，使得电极施加电刺激。 在梅尼埃尔袭击期间，应用预定的电刺激来恢复自发的前庭活动。 应用连续，未调节的电刺激来抑制前庭功能单侧损失的症状。 此外，电极记录电诱发复合动作电位（eCAP）。 基于记录的eCAP确定用于放置电极阵列的适当位置。

公开(公告)号：US20190070413A1

公开(公告)日：2019-03-07

申请号：US13526250

申请日：2012-06-18

申请人： James O. Phillips ,  Steven M. Bierer ,  Leo Ling ,  Kaibao Nie ,  Jay Rubinstein

发明人： James O. Phillips ,  Steven M. Bierer ,  Leo Ling ,  Kaibao Nie ,  Jay Rubinstein

IPC分类号： A61N1/36 ,  A61B5/00 ,  A61N1/375 ,  A61N1/372

摘要： The present technology is directed to vestibular prostheses and associated systems and methods. In several embodiments, for example, a vestibular prosthesis includes an external rotational sensor configured to receive velocity and orientation information. The prosthesis further includes an external processor configured to convert the velocity and orientation information into an audio signal. The audio signal is sent to a cochlear implant, which applies stimulation to a semicircular ear canal in response to receiving the audio signal. In some embodiments, the processor and cochlear implant communicate in real time via an inductive link.

公开(公告)号：US20090312820A1

公开(公告)日：2009-12-17

申请号：US12476979

申请日：2009-06-02

申请人： Kaibao Nie ,  Les Atlas ,  Jay Rubinstein ,  Xing Li ,  Charles Pascal Clark

发明人： Kaibao Nie ,  Les Atlas ,  Jay Rubinstein ,  Xing Li ,  Charles Pascal Clark

IPC分类号： A61F11/04 ,  A61N1/36

CPC分类号： A61N1/36036

摘要： The restoration of melody perception is a key remaining challenge in cochlear implants. A novel sound coding strategy is proposed that converts an input audio signal into time-varying electrically stimulating pulse trains. A sound is first split into several frequency sub-bands with a fixed filter bank or a dynamic filter bank tracking harmonics in sounds. Each sub-band signal is coherently downward shifted to a low-frequency base band. These resulting coherent envelope signals have Hermitian symmetric frequency spectrums and are thus real-valued. A peak detector or high-rate sampler of half-wave rectified coherent envelope signals in each sub-band further converts the coherent envelopes into rate-varying, interleaved pulse trains. Acoustic simulations of cochlear implants using this new technique with normal hearing listeners, showed significant improvement in melody recognition over the most common conventional stimulation approach used in cochlear implants.

摘要翻译： 耳蜗感知的恢复是耳蜗植入物中仍然存在的关键问题。 提出了一种新颖的声音编码策略，将输入音频信号转换为时变电刺激脉冲串。 声音首先被分割成具有固定滤波器组或动态滤波器组的几个频率子带，以跟踪声音中的谐波。 每个子带信号相干地向下移位到低频基带。 这些产生的相干包络信号具有埃米特对称频谱，因此是实值。 每个子带中的半波整流相干包络信号的峰值检测器或高速采样器进一步将相干包络转换成速率变化的交错脉冲串。 使用这种新技术与正常听力听众的耳蜗植入物的声学模拟显示出在耳蜗植入物中使用的最常见的常规刺激方法的旋律识别显着改善。

公开(公告)号：US6078838A

公开(公告)日：2000-06-20

申请号：US23278

申请日：1998-02-13

申请人： Jay Rubinstein

发明人： Jay Rubinstein

IPC分类号： A61N1/36 ,  A61F11/00 ,  H04R25/00

CPC分类号： H04R25/75 ,  H04R25/502

摘要： A signal processing apparatus and method for neural stimulation is provided that can generate stochastic independent activity across an excited nerve or neural population. High rate pulse trains, for example, can produce random spike patterns in auditory nerve fibers that are statistically similar to those produced by spontaneous activity in the normal ear. This activity is called "pseudospontaneous activity". Varying rates of pseudospontaneous activity can be created by varying the intensity of a fixed amplitude, high rate pulse train stimulus, e.g., 5000 pps. The pseudospontaneous activity can eliminate a major difference between acoustic- and electrical-derived hearing percepts. The pseudospontaneous activity can further desynchronize the nerve fiber population as a treatment for tinnitus.

摘要翻译： 提供了一种用于神经刺激的信号处理装置和方法，其可以在兴奋的神经或神经群体上产生随机的独立活动。 例如，高速脉冲序列可以产生听觉神经纤维中的随机尖峰图案，其在与正常耳朵中的自发活动产生的统计学上相似。 这个活动被称为“假自发活动”。 假自发活动的变化率可以通过改变固定幅度，高速率脉冲序列刺激（例如5000pps）的强度来产生。 假性自发活动可以消除声和电产生的听觉感知之间的主要区别。 假性自发活动可进一步使神经纤维群体同步作为耳鸣治疗。

公开(公告)号：US08019431B2

公开(公告)日：2011-09-13

申请号：US12476979

申请日：2009-06-02

申请人： Kaibao Nie ,  Les Atlas ,  Jay Rubinstein ,  Xing Li ,  Charles Pascal Clark

发明人： Kaibao Nie ,  Les Atlas ,  Jay Rubinstein ,  Xing Li ,  Charles Pascal Clark

IPC分类号： A61N1/00

CPC分类号： A61N1/36036

摘要： The restoration of melody perception is a key remaining challenge in cochlear implants. A novel sound coding strategy is proposed that converts an input audio signal into time-varying electrically stimulating pulse trains. A sound is first split into several frequency sub-bands with a fixed filter bank or a dynamic filter bank tracking harmonics in sounds. Each sub-band signal is coherently downward shifted to a low-frequency base band. These resulting coherent envelope signals have Hermitian symmetric frequency spectrums and are thus real-valued. A peak detector or high-rate sampler of half-wave rectified coherent envelope signals in each sub-band further converts the coherent envelopes into rate-varying, interleaved pulse trains. Acoustic simulations of cochlear implants using this new technique with normal hearing listeners, showed significant improvement in melody recognition over the most common conventional stimulation approach used in cochlear implants.

摘要翻译： 耳蜗感知的恢复是耳蜗植入物中仍然存在的关键问题。 提出了一种新颖的声音编码策略，将输入音频信号转换为时变电刺激脉冲串。 声音首先被分割成具有固定滤波器组或动态滤波器组的几个频率子带，以跟踪声音中的谐波。 每个子带信号相干地向下移位到低频基带。 这些产生的相干包络信号具有埃米特对称频谱，因此是实值。 每个子带中的半波整流相干包络信号的峰值检测器或高速采样器进一步将相干包络转换成速率变化的交错脉冲串。 使用这种新技术与正常听力听众的耳蜗植入物的声学模拟显示出在耳蜗植入物中使用的最常见的常规刺激方法的旋律识别显着改善。

公开(公告)号：US06907130B1

公开(公告)日：2005-06-14

申请号：US09023279

申请日：1998-02-13

申请人： Jay Rubinstein ,  Blake Wilson

发明人： Jay Rubinstein ,  Blake Wilson

IPC分类号： A61F2/18 ,  A61N1/36 ,  H04R25/00

CPC分类号： A61N1/36036

摘要： A apparatus and method for inner ear implants is provided that generates signal processing stochastic independence activity across the excited neural population. A high rate pulse train can produce random spike patterns in auditory nerve fibers (hereafter “pseudospontaneous activity”) that are statistically similar to those produced by spontaneous activity in the normal auditory nerve. We call this activity “pseudospontaneous”. Varying rates of pseudospontaneous activity can be created by varying the intensity of a fixed amplitude, high rate pulse train stimulus, e.g., 5000 pps. The high rate pulse train can desynchronize the nerve fiber population and can be combined with a data signal in an inner ear implant. The pseudospontaneous activity can enhance neural representation of temporal detail and dynamic range with an inner ear implant such as a cochlear implant. The pseudospontaneous activity can further eliminate a major difference between acoustic-and electrical-derived hearing percepts.

摘要翻译： 提供了一种用于内耳植入物的装置和方法，其产生跨越兴奋神经群体的信号处理随机独立性活动。 高速脉冲串可以在听觉神经纤维（以下称为“假性自发活动”）中产生与在正常听觉神经中自发活动产生的相似的随机尖峰图案。 我们称这个活动为“假自发”。 假自发活动的变化率可以通过改变固定幅度，高速率脉冲序列刺激（例如5000pps）的强度来产生。 高速脉冲串可以使神经纤维群体不同步，并且可以与内耳植入物中的数据信号组合。 伪自发活动可以使用诸如耳蜗植入物的内耳植入物来增强时间细节和动态范围的神经表示。 假性自发活动可以进一步消除声学和电学的听觉感知之间的主要区别。