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    Pyrrolo[2,1-c][1,4]naphthodiazepine linked piperazine compounds and a process for the preparation thereof
    2.
    发明授权
    Pyrrolo[2,1-c][1,4]naphthodiazepine linked piperazine compounds and a process for the preparation thereof 有权
    吡咯并[2,1-c] [1,4]萘并氮杂哌嗪化合物及其制备方法

    公开(公告)号：US08759339B2

    公开(公告)日：2014-06-24

    申请号：US13985510

    申请日：2012-01-10

    申请人： Ahmed Kamal ,  Jayanti Naga Srirama Chandra Murty ,  Arutla Viswanath

    发明人： Ahmed Kamal ,  Jayanti Naga Srirama Chandra Murty ,  Arutla Viswanath

    IPC分类号： C07D487/04 ,  A61K31/55

    CPC分类号： C07D487/04

    摘要： The present invention provides a compound of general formula A, useful as potential antitumour agents against five human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]naphthodiazepine linked substituted piperazine conjugates attached through different alkane spacers of general formula A. (Formula I) General formula A. Where R=R′=(Formula II). n=1-9 and R″=methyl, ethyl, acetyl, benzyl, piperinoyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, pyridyl, pyrimidyl.

    摘要翻译： 本发明提供通式A的化合物，其可用作五种人癌细胞系的潜在抗肿瘤剂。 本发明还提供了制备通过不同的通式A的烷烃间隔物连接的吡咯并[2,1-c] [1,4]萘并氮杂的连接的取代的哌嗪共轭物的方法。（式I）通式A.其中R = R'=（式II）。 n = 1-9，R“=甲基，乙基，乙酰基，苄基，哌嗪基，4-氟苯基，4-氯苯基，4-甲氧基苯基，吡啶基，嘧啶基。

    Pyrrolo[2,1-c][1,4]naphthodiazepine Linked Piperazine Compounds and a Process for the Preparation Thereof
    3.
    发明申请
    Pyrrolo[2,1-c][1,4]naphthodiazepine Linked Piperazine Compounds and a Process for the Preparation Thereof 有权
    吡咯并[2,1-c] [1,4]萘并氮杂环丁哌嗪化合物及其制备方法

    公开(公告)号：US20130317211A1

    公开(公告)日：2013-11-28

    申请号：US13985510

    申请日：2012-01-10

    申请人： Ahmed Kamal ,  Jayanti Naga Srirama Chandra Murty ,  Arutla Viswanath

    发明人： Ahmed Kamal ,  Jayanti Naga Srirama Chandra Murty ,  Arutla Viswanath

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： The present invention provides a compound of general formula A, useful as potential antitumour agents against five human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]naphthodiazepine linked substituted piperazine conjugates attached through different alkane spacers of general formula A. (Formula I) General formula A. Where R=R′=(Formula II). n=1-9 and R″=methyl, ethyl, acetyl, benzyl, piperinoyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, pyridyl, pyrimidyl

    摘要翻译： 本发明提供通式A的化合物，其可用作五种人癌细胞系的潜在抗肿瘤剂。 本发明还提供了制备通过不同的通式A的烷烃间隔物连接的吡咯并[2,1-c] [1,4]萘并氮杂的连接的取代的哌嗪共轭物的方法。（式I）通式A.其中R = R'=（式II）。 乙基，乙酰基，苄基，哌嗪基，4-氟苯基，4-氯苯基，4-甲氧基苯基，吡啶基，嘧啶基