-
1.发明公开公开(公告)号：US20240045306A1
公开(公告)日：2024-02-08
申请号：US18378215
申请日：2023-10-10
发明人： Cory Pecinovsky , Barry Johnson , Ginelle Ramann
IPC分类号： G02F1/361 , C07D487/00 , G02F1/00
CPC分类号： G02F1/3617 , C07D487/00 , G02F1/0018 , G02F1/3612
摘要： Nonlinear optical chromophores having one or more diamondoid groups covalently attached to the chromophore, methods of making nonlinear optical chromophores, their use in thin films and electro-optical devices containing such nonlinear optical chromophores and thin films comprising the same.
-
公开(公告)号：US08846704B2
公开(公告)日：2014-09-30
申请号：US12524849
申请日：2008-01-31
申请人： David Gerard Bourke , Xianyong Bu , Christopher John Burns , Anthony Nicholas Cuzzupe , John Thomas Feutrill , Tracy Leah Nero , Beata Maria Blannin , Jun Zeng , Shaun Patrick Gaynor
发明人： David Gerard Bourke , Xianyong Bu , Christopher John Burns , Anthony Nicholas Cuzzupe , John Thomas Feutrill , Tracy Leah Nero , Beata Maria Blannin , Jun Zeng , Shaun Patrick Gaynor
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D413/12 , A61K31/505 , A61K31/506 , C07D239/38 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/00 , C07D487/02
摘要： The present invention relates to thiopyrimidine-based compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2 or JAK3 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases and vascular diseases.
摘要翻译： 本发明涉及作为包括JAK激酶在内的蛋白激酶抑制剂的硫嘧啶类化合物。 特别地，这些化合物对JAK1，JAK2或JAK3激酶及其组合如JAK1和JAK2是选择性的。 激酶抑制剂可用于治疗激酶相关疾病，例如免疫学和炎性疾病，包括器官移植物; 过度增生性疾病，包括癌症和骨髓增生性疾病; 病毒性疾病 代谢疾病和血管疾病。
-
公开(公告)号：US20140274884A1
公开(公告)日：2014-09-18
申请号：US14214477
申请日：2014-03-14
发明人： Kyla L. Bjornson , Kapil K. Karki , John O. Link , Hyung-jung Pyun , Adam J. Schrier , Kirk L. Stevens , James G. Taylor , Randall W. Vivian , Jeff Zablocki , Sheila Zipfel
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K31/437 , A61K31/519 , C07D203/02 , C07D487/00 , C07D487/02 , C07D498/22
摘要： Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said compounds, and pharmaceutical compositions containing said compounds.
摘要翻译： 式I化合物或其药学上可接受的盐，其中各种取代基在本文中定义，使用所述化合物的方法和含有所述化合物的药物组合物。
-
公开(公告)号：US20140051703A1
公开(公告)日：2014-02-20
申请号：US13861344
申请日：2013-04-11
发明人： David Gerard BOURKE , Xianyong Bu , Christopher John Burns , Anthony Nicholas Cuzzupe , John Thomas Feutrill , Tracy Leah Nero , Beata Maria Blannin , Jun Zeng , Shaun Patrick Gaynor
IPC分类号： C07D413/12 , C07D403/12 , C07D239/38
CPC分类号： C07D413/12 , A61K31/505 , A61K31/506 , C07D239/38 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/00 , C07D487/02
摘要： The present invention relates to thiopyrimidine-based compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2 or JAK3 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases and vascular diseases.
-
5.发明公开公开(公告)号：US20240045307A1
公开(公告)日：2024-02-08
申请号：US18378217
申请日：2023-10-10
发明人： Cory Pecinovsky , Barry Johnson , Ginelle Ramann
IPC分类号： G02F1/361 , C07D487/00 , G02F1/00
CPC分类号： G02F1/3617 , C07D487/00 , G02F1/0018 , G02F1/3612
摘要： Nonlinear optical chromophores having one or more diamondoid groups covalently attached to the chromophore, methods of making nonlinear optical chromophores, their use in thin films and electro-optical devices containing such nonlinear optical chromophores and thin films comprising the same.
-
公开(公告)号：US20170333443A1
公开(公告)日：2017-11-23
申请号：US15597671
申请日：2017-05-17
申请人： BioTheryX, Inc.
发明人： Kyle W.H. Chan , Leah Fung , Robert Sullivan , Paul E. Erdman , Frank Mercurio , Eduardo Torres
IPC分类号： A61K31/55 , A61K47/55 , A61K9/48 , A61K9/70 , A61K9/08 , A61K9/06 , A61K9/00 , A61K31/40 , A61K9/20
CPC分类号： C07D513/16 , A61K9/0014 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0053 , A61K9/006 , A61K9/007 , A61K9/0078 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/48 , A61K9/7023 , A61K31/40 , A61K31/437 , A61K31/55 , A61K38/00 , A61K47/55 , A61K2039/505 , A61K2121/00 , C07C223/02 , C07D207/04 , C07D209/00 , C07D221/00 , C07D225/02 , C07D247/02 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/14 , C07D487/00 , C07D513/14
摘要： The present invention provides chimeric compounds that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, TNF-alpha activity, CK1-alpha activity and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions, such as cytokine-mediated diseases, disorders, and conditions, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, organ transplant rejection, and cancer, are provided.
-
公开(公告)号：US20170313745A1
公开(公告)日：2017-11-02
申请号：US15455508
申请日：2017-03-10
发明人： Kyla L. Bjornson , Kapil K. Karki , John O. Link , Hyung-jung Pyun , Adam J. Schrier , Kirk L. Stevens , James G. Taylor , Randall W. Vivian , Jeff Zablocki , Sheila M. Zipfel
IPC分类号： C07K7/64 , C07D487/02 , C07D487/00 , C07D203/02 , A61K31/519 , C07D498/22 , A61K31/437
CPC分类号： C07K7/64 , A61K31/437 , A61K31/519 , C07D203/02 , C07D487/00 , C07D487/02 , C07D498/22
摘要： Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said compounds, and pharmaceutical compositions containing said compounds.
-
8.发明申请公开(公告)号：US20170260187A1
公开(公告)日：2017-09-14
申请号：US15511697
申请日：2014-10-28
发明人： János SZOLCSÁNYI , Erika PINTÉR , Zsuzsanna HELYES , Éva SZÖKE , Frigyes WÁCZEK , László ÖRFI , György KÉRI , Tamás SZÜTS
IPC分类号： C07D487/00
CPC分类号： C07D487/00
摘要： The present invention relates to 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives of the and solvates, hydrates and pharmaceutically acceptable salts thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical N compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia. Said 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine compounds have been identified as new drug candidates for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia.
-
公开(公告)号：US09403800B2
公开(公告)日：2016-08-02
申请号：US13748770
申请日：2013-01-24
申请人： John Cashman , Mark Mercola , Dennis Schade , Masanao Tsuda
发明人： John Cashman , Mark Mercola , Dennis Schade , Masanao Tsuda
IPC分类号： C07D403/12 , C07D487/00 , A61K31/635 , C07D401/12 , C07D413/12 , C07H17/02 , A61K45/06 , A61K31/706 , A61K31/4745 , A61K31/513 , A61K31/555
CPC分类号： C07D403/12 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/635 , A61K31/706 , A61K45/06 , C07D401/12 , C07D413/12 , C07D487/00 , C07H17/02 , A61K2300/00
摘要： Methods and small molecule compounds for inhibition of cancer cell proliferation are provided. One example of a class of compounds that may be used is represented by the compound of Formula I or a pharmaceutically acceptable salt, N-oxide or solvate thereof, wherein A, B, D, E, F, G, I, J, R, R1, R2, R2′, R3, R4, R5, R6, R7, R8, R9 are as described herein.
摘要翻译： 提供了抑制癌细胞增殖的方法和小分子化合物。 可以使用的一类化合物的一个实例由式I化合物或其药学上可接受的盐，N-氧化物或溶剂化物表示，其中A，B，D，E，F，G，I，J，R ，R1，R2，R2'，R3，R4，R5，R6，R7，R8，R9如本文所述。
-
公开(公告)号：US20140045848A1
公开(公告)日：2014-02-13
申请号：US13861334
申请日：2013-04-11
发明人： David Gerard Bourke , Xianyong Bu , Christopher John Burns , Anthony Nicholas Cuzzupe , John Thomas Feutrill , Tracy Leah Nero , Beata Maria Blannin , Jun Zeng , Shaun Patrick Gaynor
IPC分类号： C07D413/12 , C07D403/12 , C07D239/38
CPC分类号： C07D413/12 , A61K31/505 , A61K31/506 , C07D239/38 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/00 , C07D487/02
摘要： The present invention relates to thiopyrimidine-based compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2 or JAK3 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases and vascular diseases.
摘要翻译： 本发明涉及作为包括JAK激酶在内的蛋白激酶抑制剂的硫嘧啶类化合物。 特别地，这些化合物对JAK1，JAK2或JAK3激酶及其组合如JAK1和JAK2是选择性的。 激酶抑制剂可用于治疗激酶相关疾病，例如免疫学和炎性疾病，包括器官移植物; 过度增生性疾病，包括癌症和骨髓增生性疾病; 病毒性疾病 代谢性疾病和血管疾病。
-
-
-
-
-
-
-
-
-
搜索结果
33 条记录 (耗时 0.03 秒)
