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12 条记录 (耗时 0.016 秒)

    Process for enzymatic deacylation of antibiotics
    3.
    发明授权
    Process for enzymatic deacylation of antibiotics 失效
    抗生素的酶脱酰基化过程

    公开(公告)号：US4282322A

    公开(公告)日：1981-08-04

    申请号：US70082

    申请日：1979-08-27

    申请人： Jean S. Kahan ,  Frederick M. Kahan

    发明人： Jean S. Kahan ,  Frederick M. Kahan

    IPC分类号： C07D477/20 ,  C12N9/80 ,  C12P17/18

    CPC分类号： C07D477/20 ,  C12N9/80 ,  C12P17/184 ,  Y10S435/822

    摘要： This invention relates to two new antibiotics, desacetyl 890A.sub.1 and desacetyl 890A.sub.3, active against both gram-positive and gram-negative bacteria, which are produced by treating 890A.sub.1 and 890A.sub.3, respectively, with an N-acetylthienamycin amidohydrolase produced by a soil microorganism isolated by enrichment techniques. This invention also relates to the process whereby N-acetylated structures of the thienamycin class of antibiotics such as N-acetyl thienamycin can be enzymatically deacetylated.

    摘要翻译： 本发明涉及两种新型抗生素，即脱乙酰890A1和去乙酰基890A3，其对革兰氏阳性菌和革兰氏阴性菌均具有活性，其分别通过由分离自土壤微生物的土壤微生物产生的N-乙酰硫霉素酰胺水解酶处理890A1和890A3而产生 浓缩技术 本发明还涉及可以将N-乙酰基噻吩霉素等噻吩霉素类抗生素的N-乙酰化结构酶促脱乙酰化的方法。

    Enzymatic cleavage of N-acyl-thienamycins
    7.
    发明授权
    Enzymatic cleavage of N-acyl-thienamycins 失效
    N-酰基 - 噻吩霉素的酶切割

    公开(公告)号：US4162193A

    公开(公告)日：1979-07-24

    申请号：US825883

    申请日：1977-08-19

    申请人： Jean S. Kahan ,  Frederick M. Kahan

    发明人： Jean S. Kahan ,  Frederick M. Kahan

    IPC分类号： C12P17/18 ,  C07D477/20 ,  C12R1/19 ,  C12D13/06

    CPC分类号： C07D477/20

    摘要： A method is disclosed for cleaving N-acyl-thienamycin compounds to yield thienamycin. The new method disclosed herein utilizes enzymes which are penicillin amidohydrolases to treat the starting compounds resulting in the antibiotic thienamycin.

    摘要翻译： {PG，1公开了一种用于切割N-酰基 - 西叶霉素化合物以产生噻吩霉素的方法。 本文公开的新方法使用作为青霉素酰胺水解酶的酶来治疗引起抗生素硫威霉素的起始化合物。

    Production of N-acyl-thienamycins
    8.
    发明授权
    Production of N-acyl-thienamycins 失效
    生产N-乙酰基氨基甲酸酯

    公开(公告)号：US4135978A

    公开(公告)日：1979-01-23

    申请号：US825884

    申请日：1977-08-19

    申请人： Jean S. Kahan ,  Frederick M. Kahan

    发明人： Jean S. Kahan ,  Frederick M. Kahan

    IPC分类号： C07D477/20 ,  C12P17/18 ,  C12D13/06

    CPC分类号： C07D477/20 ,  C12P17/184

    摘要： The disclosed invention is directed to a process for preparing N-acyl-thienamycins from thienamycin and the appropriate acyl group by reacting the same in the presence of certain penicillin amidohydrolases capable of producing N-acyl thienamycins.

    摘要翻译： 所公开的发明涉及通过在能够产生N-酰基噻吩霉素的某些青霉素酰胺水解酶的存在下使其从噻吩霉素和适当的酰基上制备N-酰基 - 噻吩霉素的方法。

    Process for producing antibiotic desacetyl 890A.sub.10
    9.
    发明授权
    Process for producing antibiotic desacetyl 890A.sub.10 失效
    生产抗生素脱乙酰基890A10的方法

    公开(公告)号：US4264734A

    公开(公告)日：1981-04-28

    申请号：US74289

    申请日：1979-09-11

    申请人： Jean S. Kahan ,  Frederick M. Kahan

    发明人： Jean S. Kahan ,  Frederick M. Kahan

    IPC分类号： C07D477/20 ,  C12P17/18

    CPC分类号： C07D477/20 ,  C12P17/184 ,  Y10S435/822

    摘要： This invention relates to the new antibiotic, desacetyl 890A.sub.10, active against both gram-positive and gram-negative bacteria, which is produced by treating 890A.sub.10 with an N-acetyl-890A.sub.10 amidohydrolase produced by a soil microorganism isolated by enrichment techniques. This invention also relates to the process by which 890A.sub.10 is enzymatically deacetylated.

    摘要翻译： 本发明涉及通过用通过富集技术分离的土壤微生物产生的N-乙酰基-890A10酰胺水解酶处理890A10而产生的革兰氏阳性和革兰氏阴性细菌的新型抗生素脱乙酰基890A10。 本发明还涉及890A10被酶脱乙酰化的方法。