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1.发明申请GLYCOPEPTIDES DERIVED FROM PANCREATIC STRUCTURES, ANTIBODIES AND APPLICATIONS THEREOF IN DIAGNOSTICS AND THERAPEUTICS 有权从胰腺结构衍生的胰蛋白酶，抗体及其在诊断和治疗中的应用公开(公告)号：US20090285823A1
公开(公告)日：2009-11-19
申请号：US12488793
申请日：2009-06-22
申请人： Dominique Lombardo , Eric Mas , Marie-Odile Sadoulet , Laurence Panicot-Dubois , Jean-Paul Bernard
发明人： Dominique Lombardo , Eric Mas , Marie-Odile Sadoulet , Laurence Panicot-Dubois , Jean-Paul Bernard
IPC分类号： A61K39/395 , G01N33/53 , A61K39/00
摘要： Glycopeptide comprising 1 to 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby said polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for said polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases, anti-glycopeptide antibodies and the applications thereof in therapeutics and diagnostics.
摘要翻译： 包含1至40个重复C末端多肽，具有11个氨基酸的BSDL或FAPP的糖肽，其中所述多肽被糖基化并承载糖基化表位，在患有1型糖尿病的患者中引起与诱导抗体的特异性免疫反应，和/ 或从人或动物来源的生物流体或重组体中纯化并通过在包含引发糖基化所必需的酶材料的标准宿主细胞中表达产生，所述宿主细胞被遗传修饰以包含编码所述多肽的基因和基因 编码选自糖基转移酶，抗糖肽抗体中的一种或多种酶及其在治疗和诊断中的应用。
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2.发明授权公开(公告)号：US07557193B2
公开(公告)日：2009-07-07
申请号：US10593859
申请日：2005-03-30
申请人： Dominique Lombardo , Eric Mas , Marie-Odile Sadoulet , Laurence Panicot-Dubois , Jean-Paul Bernard
发明人： Dominique Lombardo , Eric Mas , Marie-Odile Sadoulet , Laurence Panicot-Dubois , Jean-Paul Bernard
IPC分类号： C07K16/00
摘要： The invention relates to a glycopeptide comprising between 1 and 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby the aforementioned polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes, and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for the aforementioned polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases and anti-glycopeptide antibodies. The invention also relates to the applications thereof in therapeutics and diagnostics.
摘要翻译： 本发明涉及包含1至40个具有11个氨基酸的BSDL或FAPP的1至40个重复C末端多肽的糖肽，由此上述多肽被糖基化并且承载糖基化表位，引起患者中诱导的抗体的特异性免疫反应 患有1型糖尿病和/或从人或动物来源的生物流体或重组体纯化并通过在包含引发糖基化所必需的酶材料的标准宿主细胞中表达而产生，所述宿主细胞经遗传修饰，包括 编码上述多肽的基因和编码选自糖基转移酶和抗糖肽抗体中的一种或多种酶的基因。 本发明还涉及其在治疗和诊断中的应用。
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公开(公告)号：US4102518A
公开(公告)日：1978-07-25
申请号：US835930
申请日：1977-09-23
IPC分类号： B64F1/02
CPC分类号： B64F1/02
摘要： In a gear for arresting aircraft at the ends of a takeoff or landing strip, a net is protected against weather conditions by being folded and enclosed in a bag pressed against the strip tarmac by fixed ropes, a movable rope being provided for normally closing said bag. When this rope is released, the net can move out from the bag, the rope movement being associated with the actuation of the posts supporting the lateral ends of the net disposed across the strip.
摘要翻译： 在起飞或着陆带的末端拦截飞机的装置，通过折叠并封闭在通过固定绳索压靠在柏油碎石碎石机上的袋子中来防止天气状况的网，提供用于正常关闭所述袋子的可移动绳索 。 当该绳索被释放时，网可以从袋子移出，绳索运动与支撑跨越条带布置的网的横向端部的柱的致动相关联。
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公开(公告)号：US4056247A
公开(公告)日：1977-11-01
申请号：US711661
申请日：1976-08-04
IPC分类号： B64F1/02
CPC分类号： B64F1/02
摘要： In this device for raising the net of an aircraft arresting gear, a post is pivotally mounted on each side of the strip in a frame structure disposed obliquely to the center line of the strip, this post being pivotally connected intermediate its ends to the piston-rod of a pneumatic cylinder, the net suspension rope passing through the top of each post before being anchored to the ground.
摘要翻译： 在用于提升飞机拦阻齿轮的网的装置中，柱以可倾斜于条的中心线设置的框架结构枢转地安装在条的每侧上，该柱在其端部之间枢转地连接到活塞 - 气动缸的杆，净悬挂绳索通过每个柱的顶部，然后锚固到地面。
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公开(公告)号：US3952831A
公开(公告)日：1976-04-27
申请号：US552744
申请日：1975-02-25
申请人： Jean-Paul Bernard , Pierre Jules Henry Brussieux , Louis Francois Jumelle , Jean Lucien Simonin
发明人： Jean-Paul Bernard , Pierre Jules Henry Brussieux , Louis Francois Jumelle , Jean Lucien Simonin
CPC分类号： B32B3/12 , E04B1/86 , E04C2/365 , F02C7/24 , G10K11/172 , E04B2001/748 , Y02T50/672
摘要： A composite material with acoustic absorption properties of the "sandwich"ype has a core of cellular structure between two skins substantially parallel one of which is cut-out by orifices while the other is devoid of orifices. The core is composed of a plurality of cells each of which extends from one skin to the other. A plurality of small plates, of material with high acoustic resistivity, are inserted into the cellular structure. Each plate has an active part contained in a plane substantially parallel to the skins, so that the active parts form, together, the equivalent of an intermediary wall of high acoustic resistivity dividing the cellular structure into two superposed layers each formed by a mass of sub-cells.
摘要翻译： 具有“夹心”型吸声性质的复合材料具有基本平行的两个表皮之间的细胞结构核心，其中一个被孔切开，而另一个没有孔。 核心由多个细胞组成，每个细胞从一个皮肤延伸到另一个皮肤。 将具有高声电阻率的材料的多个小板插入到蜂窝结构中。 每个板具有包含在基本上平行于表面的平面中的活性部分，使得活性部分一起形成将细胞结构分成两个叠加层的高声电阻中间壁的等效物，每个叠层由质量的子 -细胞。
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6.发明申请公开(公告)号：US20070172485A1
公开(公告)日：2007-07-26
申请号：US10593859
申请日：2005-03-30
申请人： Dominique Lombardo , Eric Mas , Marie-Odile Sadoulet , Laurence Panicot-Dubois , Jean-Paul Bernard
发明人： Dominique Lombardo , Eric Mas , Marie-Odile Sadoulet , Laurence Panicot-Dubois , Jean-Paul Bernard
IPC分类号： A61K39/395 , G01N33/574 , C12P21/06 , C07K16/30
摘要： The invention relates to a glycopeptide comprising between 1 and 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby the aforementioned polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes, and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for the aforementioned polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases and anti-glycopeptide antibodies. The invention also relates to the applications thereof in therapeutics and diagnostics.
摘要翻译： 本发明涉及包含1至40个具有11个氨基酸的BSDL或FAPP的1至40个重复C末端多肽的糖肽，由此上述多肽被糖基化并且承载糖基化表位，引起患者中诱导的抗体的特异性免疫反应 患有1型糖尿病和/或从人或动物来源的生物流体或重组体纯化并通过在包含引发糖基化所必需的酶材料的标准宿主细胞中表达而产生，所述宿主细胞经遗传修饰，包括 编码上述多肽的基因和编码选自糖基转移酶和抗糖肽抗体中的一种或多种酶的基因。 本发明还涉及其在治疗和诊断中的应用。
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公开(公告)号：US3200906A
公开(公告)日：1965-08-17
申请号：US31400163
申请日：1963-10-04
申请人： JEAN-PAUL BERNARD
发明人： JEAN-PAUL BERNARD
IPC分类号： B64F1/02
CPC分类号： B64F1/02
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8.发明授权公开(公告)号：US08367062B2
公开(公告)日：2013-02-05
申请号：US12488793
申请日：2009-06-22
申请人： Dominique Lombardo , Eric Mas , Marie-Odile Sadoulet , Laurence Panicot-Dubois , Jean-Paul Bernard
发明人： Dominique Lombardo , Eric Mas , Marie-Odile Sadoulet , Laurence Panicot-Dubois , Jean-Paul Bernard
IPC分类号： A61K39/395
摘要： Glycopeptide comprising 1 to 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby said polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for said polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases, anti-glycopeptide antibodies and the applications thereof in therapeutics and diagnostics.
摘要翻译： 包含1至40个重复C末端多肽，具有11个氨基酸的BSDL或FAPP的糖肽，其中所述多肽被糖基化并承载糖基化表位，在患有1型糖尿病的患者中引起与诱导抗体的特异性免疫反应，和/ 或从人或动物来源的生物流体或重组体中纯化并通过在包含引发糖基化所必需的酶材料的标准宿主细胞中表达产生，所述宿主细胞被遗传修饰以包含编码所述多肽的基因和基因 编码选自糖基转移酶，抗糖肽抗体中的一种或多种酶及其在治疗和诊断中的应用。
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