公开(公告)号：US07557193B2

公开(公告)日：2009-07-07

申请号：US10593859

申请日：2005-03-30

申请人： Dominique Lombardo ,  Eric Mas ,  Marie-Odile Sadoulet ,  Laurence Panicot-Dubois ,  Jean-Paul Bernard

发明人： Dominique Lombardo ,  Eric Mas ,  Marie-Odile Sadoulet ,  Laurence Panicot-Dubois ,  Jean-Paul Bernard

IPC分类号： C07K16/00

CPC分类号： C12N9/20 ,  A61K38/00

摘要： The invention relates to a glycopeptide comprising between 1 and 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby the aforementioned polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes, and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for the aforementioned polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases and anti-glycopeptide antibodies. The invention also relates to the applications thereof in therapeutics and diagnostics.

摘要翻译： 本发明涉及包含1至40个具有11个氨基酸的BSDL或FAPP的1至40个重复C末端多肽的糖肽，由此上述多肽被糖基化并且承载糖基化表位，引起患者中诱导的抗体的特异性免疫反应 患有1型糖尿病和/或从人或动物来源的生物流体或重组体纯化并通过在包含引发糖基化所必需的酶材料的标准宿主细胞中表达而产生，所述宿主细胞经遗传修饰，包括 编码上述多肽的基因和编码选自糖基转移酶和抗糖肽抗体中的一种或多种酶的基因。 本发明还涉及其在治疗和诊断中的应用。

公开(公告)号：US08367062B2

公开(公告)日：2013-02-05

申请号：US12488793

申请日：2009-06-22

申请人： Dominique Lombardo ,  Eric Mas ,  Marie-Odile Sadoulet ,  Laurence Panicot-Dubois ,  Jean-Paul Bernard

发明人： Dominique Lombardo ,  Eric Mas ,  Marie-Odile Sadoulet ,  Laurence Panicot-Dubois ,  Jean-Paul Bernard

IPC分类号： A61K39/395

CPC分类号： C12N9/20 ,  A61K38/00

摘要： Glycopeptide comprising 1 to 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby said polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for said polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases, anti-glycopeptide antibodies and the applications thereof in therapeutics and diagnostics.

摘要翻译： 包含1至40个重复C末端多肽，具有11个氨基酸的BSDL或FAPP的糖肽，其中所述多肽被糖基化并承载糖基化表位，在患有1型糖尿病的患者中引起与诱导抗体的特异性免疫反应，和/ 或从人或动物来源的生物流体或重组体中纯化并通过在包含引发糖基化所必需的酶材料的标准宿主细胞中表达产生，所述宿主细胞被遗传修饰以包含编码所述多肽的基因和基因 编码选自糖基转移酶，抗糖肽抗体中的一种或多种酶及其在治疗和诊断中的应用。

公开(公告)号：US20070172485A1

公开(公告)日：2007-07-26

申请号：US10593859

申请日：2005-03-30

申请人： Dominique Lombardo ,  Eric Mas ,  Marie-Odile Sadoulet ,  Laurence Panicot-Dubois ,  Jean-Paul Bernard

发明人： Dominique Lombardo ,  Eric Mas ,  Marie-Odile Sadoulet ,  Laurence Panicot-Dubois ,  Jean-Paul Bernard

IPC分类号： A61K39/395 ,  G01N33/574 ,  C12P21/06 ,  C07K16/30

CPC分类号： C12N9/20 ,  A61K38/00

摘要： The invention relates to a glycopeptide comprising between 1 and 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby the aforementioned polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes, and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for the aforementioned polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases and anti-glycopeptide antibodies. The invention also relates to the applications thereof in therapeutics and diagnostics.

摘要翻译： 本发明涉及包含1至40个具有11个氨基酸的BSDL或FAPP的1至40个重复C末端多肽的糖肽，由此上述多肽被糖基化并且承载糖基化表位，引起患者中诱导的抗体的特异性免疫反应 患有1型糖尿病和/或从人或动物来源的生物流体或重组体纯化并通过在包含引发糖基化所必需的酶材料的标准宿主细胞中表达而产生，所述宿主细胞经遗传修饰，包括 编码上述多肽的基因和编码选自糖基转移酶和抗糖肽抗体中的一种或多种酶的基因。 本发明还涉及其在治疗和诊断中的应用。

公开(公告)号：US20090285823A1

公开(公告)日：2009-11-19

申请号：US12488793

申请日：2009-06-22

申请人： Dominique Lombardo ,  Eric Mas ,  Marie-Odile Sadoulet ,  Laurence Panicot-Dubois ,  Jean-Paul Bernard

发明人： Dominique Lombardo ,  Eric Mas ,  Marie-Odile Sadoulet ,  Laurence Panicot-Dubois ,  Jean-Paul Bernard

IPC分类号： A61K39/395 ,  G01N33/53 ,  A61K39/00

CPC分类号： C12N9/20 ,  A61K38/00

摘要： Glycopeptide comprising 1 to 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby said polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for said polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases, anti-glycopeptide antibodies and the applications thereof in therapeutics and diagnostics.

摘要翻译： 包含1至40个重复C末端多肽，具有11个氨基酸的BSDL或FAPP的糖肽，其中所述多肽被糖基化并承载糖基化表位，在患有1型糖尿病的患者中引起与诱导抗体的特异性免疫反应，和/ 或从人或动物来源的生物流体或重组体中纯化并通过在包含引发糖基化所必需的酶材料的标准宿主细胞中表达产生，所述宿主细胞被遗传修饰以包含编码所述多肽的基因和基因 编码选自糖基转移酶，抗糖肽抗体中的一种或多种酶及其在治疗和诊断中的应用。