公开(公告)号：US08092819B2

公开(公告)日：2012-01-10

申请号：US11655300

申请日：2007-01-19

申请人： Patrick H. Ruane ,  Jeff P. Little ,  Andrew P. Isch

发明人： Patrick H. Ruane ,  Jeff P. Little ,  Andrew P. Isch

IPC分类号： A61F13/00 ,  A61F2/06 ,  C07H21/04

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/426 ,  A61L2300/602 ,  A61L2300/606 ,  C08L35/04

摘要： The present invention provides an implantable medical device comprising a bioactive agent and poly(alkyl cyanoacrylate) polymer. In one embodiment of the invention, the bioactive agent is a water-soluble material, such as an antisense agent.

摘要翻译： 本发明提供了包含生物活性剂和聚（氰基丙烯酸烷基酯）聚合物的可植入医疗装置。 在本发明的一个实施方案中，生物活性剂是水溶性物质，例如反义剂。

公开(公告)号：US08092864B2

公开(公告)日：2012-01-10

申请号：US12199189

申请日：2008-08-27

申请人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

发明人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

IPC分类号： B05D3/00

CPC分类号： B05D1/02 ,  A61F2/88 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  B05D1/002 ,  C08L67/04

摘要： Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device. Improved coating uniformity may be achieved by providing an annular space between the luminal surface of the medical device and an axial member. Coating on the luminal surface may be minimized by providing an axial member having an outer diameter that is greater than the maximum width or length of the spray contacting the axial member after passing through the openings in the medical device.

摘要翻译： 提供涂覆医疗装置的方法以改善涂层的均匀性并减少涂层不规则，同时减少医疗装置的腔表面的直接涂覆。 优选地，涂覆管状医疗装置的方法包括以下步骤：将管状医疗装置定位在心轴涂层组件周围，将管状医疗装置安装在心轴涂层组件上，并将包括治疗剂和溶剂的包衣溶液喷涂在腹腔镜 安装在心轴涂层组件上的管状医疗装置的表面。 心轴涂层组件可以包括直径小于管状医疗装置的内腔的直径的轴向构件，以及从轴向构件延伸到外表面的至少一个环形凸起，该外表面的直径大于或基本上等于 医疗装置的管腔直径。 可以通过在医疗装置的腔表面和轴向构件之间提供环形空间来实现改进的涂层均匀性。 通过提供具有大于在穿过医疗装置中的开口之后接触轴向构件的喷雾器的最大宽度或长度的外径的轴向构件，腔体表面上的涂层可以最小化。

公开(公告)号：US20090061072A1

公开(公告)日：2009-03-05

申请号：US12199189

申请日：2008-08-27

申请人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

发明人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

IPC分类号： B05D5/00

CPC分类号： B05D1/02 ,  A61F2/88 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  B05D1/002 ,  C08L67/04

摘要： Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device. Improved coating uniformity may be achieved by providing an annular space between the luminal surface of the medical device and an axial member. Coating on the luminal surface may be minimized by providing an axial member having an outer diameter that is greater than the maximum width or length of the spray contacting the axial member after passing through the openings in the medical device.

摘要翻译： 提供涂覆医疗装置的方法以改善涂层的均匀性并减少涂层不规则，同时减少医疗装置的腔表面的直接涂覆。 优选地，涂覆管状医疗装置的方法包括以下步骤：将管状医疗装置定位在心轴涂层组件周围，将管状医疗装置安装在心轴涂层组件上，并将包括治疗剂和溶剂的包衣溶液喷涂在腹腔镜 安装在心轴涂层组件上的管状医疗装置的表面。 心轴涂层组件可以包括直径小于管状医疗装置的内腔的直径的轴向构件，以及从轴向构件延伸到外表面的至少一个环形凸起，该外表面的直径大于或基本上等于 医疗装置的管腔直径。 可以通过在医疗装置的腔表面和轴向构件之间提供环形空间来实现改进的涂层均匀性。 通过提供具有大于在穿过医疗装置中的开口之后接触轴向构件的喷雾器的最大宽度或长度的外径的轴向构件，腔体表面上的涂层可以最小化。