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公开(公告)号：US20120189601A1
公开(公告)日：2012-07-26
申请号：US13496180
申请日：2010-09-15
申请人： Jeffrey D. Esko , Yitzhak Tor
发明人： Jeffrey D. Esko , Yitzhak Tor
CPC分类号： A61K38/47 , A61K47/549 , A61K47/61 , C12Y302/01031
摘要： Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.
摘要翻译： 提供了可用于合成包含胍基化的环状缩醛的缀合物的试剂和方法。 还提供了增加各种治疗化合物的细胞摄取和使用这些缀合物的治疗方式的方法。
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2.发明授权Compositions and methods for treatment of disease with acetylated disaccharides 有权用乙酰化二糖治疗疾病的组合物和方法公开(公告)号：US07772192B2
公开(公告)日：2010-08-10
申请号：US10559260
申请日：2004-06-01
申请人： Jeffrey D. Esko
发明人： Jeffrey D. Esko
IPC分类号： A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7024 , C07H15/18 , C07H15/20 , C07H15/203 , C07H15/256 , C07H15/04
CPC分类号： C07H13/04 , C07H15/04 , C07H15/18 , C07H15/203 , C07H15/26 , C07H17/02 , C07H17/04 , G01N33/5011
摘要： Compositions and methods for treatment of disease with acetylated disaccharides and analogs thereof are provided.
摘要翻译： 提供了用乙酰化二糖及其类似物治疗疾病的组合物和方法。
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公开(公告)号：US5639734A
公开(公告)日：1997-06-17
申请号：US359582
申请日：1994-12-20
申请人： Jeffrey D. Esko , Arun K. Sarkar
发明人： Jeffrey D. Esko , Arun K. Sarkar
IPC分类号： C07H15/18 , C07H15/203 , A61K31/70 , C07H15/00 , C07H17/00
CPC分类号： C07H15/18 , C07H15/203
摘要： The present invention provides a composition of matter comprising a biosynthetic anti-inflammatory oligosaccharide, comprising the structure of: sugar - sugar - X - R; wherein said sugar is selected from the group consisting of N-acetylneuraminic acid, galactose, N-acetylglucosamine, N-acetylgalactosamine, fucose and mannose; wherein X is a bridging atom selected from the group consisting of oxygen, sulfur, nitrogen and carbon; and wherein R is an aglycone selected from the group consisting of naphthol, naphthalenemethane, indenol, a heterocyclic derivative of indenol, a heterocyclic derivative of naphthol and a heterocyclic derivative of naphthalenemethanol. Also provided is a method of treating an inflammatory disease in an individual comprising the step of administering to said individual a therapeutically effective dose of the novel composition of the present invention.
摘要翻译： 本发明提供了包含生物合成抗炎寡糖的物质组合物，其包含以下结构：糖 - 糖-X-R; 其中所述糖选自N-乙酰神经氨酸，半乳糖，N-乙酰葡糖胺，N-乙酰半乳糖胺，岩藻糖和甘露糖; 其中X是选自氧，硫，氮和碳的桥连原子; 并且其中R是选自萘酚，萘甲烷，茚醇，茚醇的杂环衍生物，萘酚的杂环衍生物和萘甲醇的杂环衍生物的糖苷配基。 还提供了治疗个体炎性疾病的方法，包括向所述个体施用治疗有效剂量的本发明的新型组合物的步骤。
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公开(公告)号：US5104856A
公开(公告)日：1992-04-14
申请号：US611255
申请日：1990-11-09
摘要： Conjugates of .beta.-D-xylose with estrogens or modified forms of estrogens are effective in stimulating the synthesis of heparan sulfate, and inhibiting the production of proteoglycan in animal subjects. Accordingly, these conjugates are useful in treating conditions where antithrombotic or antiproliferative activity is desirable.
摘要翻译： β-D-木糖与雌激素或修饰形式的雌激素的缀合物有效刺激硫酸乙酰肝素的合成，并抑制动物受试者中蛋白多糖的产生。 因此，这些缀合物可用于治疗需要抗血栓形成或抗增殖活性的病症。
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公开(公告)号：US09889182B2
公开(公告)日：2018-02-13
申请号：US13496180
申请日：2010-09-15
申请人： Jeffrey D. Esko , Yitzhak Tor
发明人： Jeffrey D. Esko , Yitzhak Tor
CPC分类号： A61K38/47 , A61K47/549 , A61K47/61 , C12Y302/01031
摘要： Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.
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公开(公告)号：US20080268013A1
公开(公告)日：2008-10-30
申请号：US11815993
申请日：2006-02-10
IPC分类号： C08F251/00 , A61F2/00 , C12N5/06 , A61P37/00 , A61P29/00 , A61K31/765 , A61F2/82
CPC分类号： A61K31/77 , C08G65/2606 , C08G65/3314 , C08G65/3356 , C08L71/02 , C08L85/02 , C08L2203/02 , C08L2666/22
摘要： Poly(ethylene oxide) (PEO) glycodendrimers can serve as multivalent inhibitors of selectin-mediated leukocyte recruitment regulating inflammatory response. Disclosed are compounds and methods relating to functionalized branched glycopolymers. In embodiments, the compounds are capable of modifying cell adhesion events and inflammatory conditions. In a particular embodiment, a multi-arm PEO polymer with sulfated lactose end groups can specifically inhibit interactions involving L-selectin. Also disclosed are methods of synthetic preparation and use.
摘要翻译： 聚（环氧乙烷）（PEO）糖苷配基聚合物可以作为调节炎症反应的选择素介导的白细胞募集的多价抑制剂。 公开了与官能化支链糖聚合物有关的化合物和方法。 在实施方案中，化合物能够改变细胞粘附事件和炎性病症。 在具体实施方案中，具有硫酸化乳糖末端基团的多臂PEO聚合物可以特异性抑制涉及L-选择蛋白的相互作用。 还公开了合成制备和使用的方法。
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公开(公告)号：US20230321101A1
公开(公告)日：2023-10-12
申请号：US18022254
申请日：2021-08-20
申请人： Philip L.S.M. GORDTS , Andrea DENARDO , Ryan Joseph WEISS , Chelsea NORA , Jeffrey D. Esko , CLAUSEN Thomas Mandel , Daniel R. SANDOVAL , The Regents of the University of California
发明人： Philip L.S.M. Gordts , Andrea Denardo , Ryan Joseph Weiss , Chelsea Nora , Jeffrey D. Esko , Thomas Mandel-Clausen , Daniel R. Sandoval
IPC分类号： A61K31/517 , A61P31/14
CPC分类号： A61K31/517 , A61P31/14
摘要： The present disclosure relates to treatment or prevention of a disease, such as COVID-19, in a subject by administering to the subject a therapeutically effective amount of halofuginone or a derivative or pharmaceutically acceptable salt thereof.
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