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1.发明授权公开(公告)号：US06355434B1
公开(公告)日：2002-03-12
申请号：US09617871
申请日：2000-07-17
申请人： Jeffrey M. Drazen , Kwang-Ho In , Koichiro Asano , David Beier , James Grobholz
发明人： Jeffrey M. Drazen , Kwang-Ho In , Koichiro Asano , David Beier , James Grobholz
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention provides identification of sequence polymorphisms in the 5-lipoxygenase gene that are present in general and asthmatic populations. The invention provides methods associated with correlating such polymorphisms with asthmatic phenotype and responsiveness to therapy. In particular, the invention demonstrates that individuals with reduced 5-lipoxygenase expression (or activity) are less responsive to treatment with 5-lipoxygenase inhibiters.
摘要翻译： 本发明提供了在一般和哮喘人群中存在的5-脂肪氧合酶基因中的序列多态性的鉴定。 本发明提供了将这些多态性与哮喘表型和对治疗的反应性相关联的方法。 特别地，本发明证明具有降低的5-脂氧合酶表达（或活性）的个体对用5-脂氧合酶抑制剂的治疗反应较差。
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2.发明授权Methods for diagnosis, prediction and treatment of asthma and other inflammatory conditions based on eotaxin coding sequence polymorphism 失效基于嗜酸性粒细胞趋化因子编码序列多态性的哮喘和其他炎性病症的诊断，预测和治疗方法公开(公告)号：US06949637B2
公开(公告)日：2005-09-27
申请号：US10413255
申请日：2003-04-14
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Methods and compositions for diagnosing and treating asthma are provided. The methods involve the discovery of a correlation between an eotaxin gene polymorphism and the ocurrence of asthma.
摘要翻译： 提供了诊断和治疗哮喘的方法和组合物。 该方法涉及发现嗜酸性粒细胞趋化因子基因多态性与哮喘发生之间的相关性。
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3.发明授权Methods for diagnosis, prediction and treatment of asthma and other inflammatory conditions based on eotaxin coding sequence polymorphism 失效基于嗜酸性粒细胞趋化因子编码序列多态性的哮喘和其他炎性病症的诊断，预测和治疗方法公开(公告)号：US06548245B1
公开(公告)日：2003-04-15
申请号：US09076259
申请日：1998-05-12
IPC分类号： A61K39395
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Methods and compositions for diagnosing and treating asthma are provided. The methods involve the discovery of a correlation between an eotaxin gene polymorphism and the occurrence of asthma.
摘要翻译： 提供了诊断和治疗哮喘的方法和组合物。 该方法涉及发现嗜酸性粒细胞趋化因子基因多态性与哮喘发生之间的相关性。
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4.发明授权
公开(公告)号：US6156503A
公开(公告)日：2000-12-05
申请号：US811441
申请日：1997-03-03
申请人： Jeffrey M. Drazen , Vern Chinchilli , Richard Martin , Robert Lemanske , Jean G. Ford , James E. Fish , Homer Boushey
发明人： Jeffrey M. Drazen , Vern Chinchilli , Richard Martin , Robert Lemanske , Jean G. Ford , James E. Fish , Homer Boushey
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention provides a novel method for identifying individuals who are likely to have negative responses to regular administration of .beta.-agonists. The invention also provides kits useful for this purpose.
摘要翻译： 本发明提供了一种用于鉴定可能对常规施用β-激动剂有负面反应的个体的新颖方法。 本发明还提供了可用于此目的的试剂盒。
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5.发明授权Identification of asthma patients who are candidates for effective treatment with 5-lipoxygenase inhibitors 失效鉴定作为5-脂氧合酶抑制剂有效治疗的候选药物的哮喘患者
公开(公告)号：US6090547A
公开(公告)日：2000-07-18
申请号：US846020
申请日：1997-04-25
申请人： Jeffrey M. Drazen , Kwang-Ho In , Koichiro Asano , David Beier , James Grobholz
发明人： Jeffrey M. Drazen , Kwang-Ho In , Koichiro Asano , David Beier , James Grobholz
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： The present invention provides identification of sequence polymorphisms in the 5-lipoxygenase gene that are present in general and asthmatic populations. The invention provides methods associated with correlating such polymorphisms with asthmatic phenotype and responsiveness to therapy. In particular, the invention demonstrates that individuals with reduced 5-lipoxygenase expression (or activity) are less responsive to treatment with 5-lipoxygenase inhibiters.
摘要翻译： 本发明提供了在一般和哮喘人群中存在的5-脂肪氧合酶基因中的序列多态性的鉴定。 本发明提供了将这些多态性与哮喘表型和对治疗的反应性相关联的方法。 特别地，本发明证明具有降低的5-脂氧合酶表达（或活性）的个体对用5-脂氧合酶抑制剂的治疗反应较差。
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