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1.发明授权Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell 有权用于将核酸引入细胞DNA的核酸转移载体公开(公告)号：US07160682B2
公开(公告)日：2007-01-09
申请号：US10191698
申请日：2002-07-09
CPC分类号： C12N15/90 , A01K2217/05 , A01K2227/40 , C12N9/22 , C12N2800/60 , C12N2800/90 , C12N2830/006 , C12N2830/80 , C12N2840/203 , C12N2840/44
摘要： The present invention provides for transposon vectors encoding expression control region-traps and gene-traps. Also provided are dicistronic vectors. Certain embodiments of the invention contain internal ribosome entry sites.
摘要翻译： 本发明提供编码表达控制区 - 陷阱和基因陷阱的转座子载体。 还提供了双顺反子载体。 本发明的某些实施方案含有内部核糖体进入位点。
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公开(公告)号：US06923973B1
公开(公告)日：2005-08-02
申请号：US10081935
申请日：2002-02-22
CPC分类号： C07K14/37 , A61K39/0002 , A61K2039/53
摘要： Disclosed are peptide and DNA compositions surprisingly found to be effective in generating immune responses against the pathogenic fungi Coccidioides spp., the causative agents of coccidioidomycosis and Valley Fever. The invention thus provides peptides and DNA constructs, combinations and related biological compositions, and prophylactic and therapeutic methods of using such components to generate effective immune responses against Coccidioides spp., including C. immitis.
摘要翻译： 公开了令人惊讶的肽和DNA组合物有效产生针对致病性真菌球孢子菌（Coccidioides spp。）的球形球菌病和谷瘟病的致病因子的免疫应答。 因此，本发明提供了肽和DNA构建体，组合和相关生物组合物，以及使用这些组分产生针对球孢子虫（Coccidioides spp。），包括伊美米霉（C.emmitis）的有效免疫应答的预防和治疗方法。
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3.发明授权Methods for diagnosis, prediction and treatment of asthma and other inflammatory conditions based on eotaxin coding sequence polymorphism 失效基于嗜酸性粒细胞趋化因子编码序列多态性的哮喘和其他炎性病症的诊断，预测和治疗方法公开(公告)号：US06949637B2
公开(公告)日：2005-09-27
申请号：US10413255
申请日：2003-04-14
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Methods and compositions for diagnosing and treating asthma are provided. The methods involve the discovery of a correlation between an eotaxin gene polymorphism and the ocurrence of asthma.
摘要翻译： 提供了诊断和治疗哮喘的方法和组合物。 该方法涉及发现嗜酸性粒细胞趋化因子基因多态性与哮喘发生之间的相关性。
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公开(公告)号：US07264954B2
公开(公告)日：2007-09-04
申请号：US10473533
申请日：2002-04-18
申请人： Akiko Sugio , Shinobu Takagi
发明人： Akiko Sugio , Shinobu Takagi
CPC分类号： C12P7/6427 , A21D8/042 , A23L33/195 , C11D3/386 , C12N9/0069 , C12Y113/11012
摘要： The present disclosure relates to an isolated lipoxygenase which is: a) a polypeptide encoded by the DNA sequence cloned into plasmid pUC19 present in Escherichia coli deposited as DSM 14139; b) a polypeptide having an amino acid sequence of the mature peptide shown in SEQ ID NO: 1; c) a polypeptide which has at least 80% homology with the polypeptide of a) or b); or d) a polypeptide encoded by DNA that hybridizes under high stringency conditions to a complementary strand of: i) the DNA sequence cloned into plasmid pUC19 present in Escherichia coli deposited as DSM 14139; or ii) the DNA sequence of SEQ ID NO: 1 encoding the mature polypeptide.
摘要翻译： 本公开涉及分离的脂氧合酶，其是：a）由克隆到以DSM14139保藏的大肠杆菌中存在的质粒pUC19中的DNA序列编码的多肽; b）具有SEQ ID NO：1所示的成熟肽的氨基酸序列的多肽; c）与a）或b）的多肽具有至少80％同源性的多肽; 或d）由高度严格条件下与下列互补链杂交的由DNA编码的多肽：i）克隆到以DSM14139保藏的大肠杆菌中存在的质粒pUC19中的DNA序列; 或ii）编码成熟多肽的SEQ ID NO：1的DNA序列。
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5.发明授权Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase 有权外消旋酶的鉴定和表征，蛋白质特征的定义以及检测D-氨基酸的试验和用于筛选能够抑制消旋酶活性的分子，特别是脯氨酸消旋酶公开(公告)号：US07262015B2
公开(公告)日：2007-08-28
申请号：US11008570
申请日：2004-12-10
CPC分类号： G01N33/573 , C12N9/90 , C12Q1/26 , C12Q1/533 , G01N33/6806 , G01N2333/99 , G01N2500/02 , Y02A90/26
摘要： This invention provides identification and characterization of racemases and definition of protein signatures of these racemases. This invention also provides identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs. Antibodies specific for the peptides and to immune complexes of these antibodies with the peptides are also provided. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.
摘要翻译： 本发明提供了消旋酶的鉴定和表征以及这些消旋物的蛋白质特征的定义。 本发明还提供了编码由蛋白质特征特征的基序组成的肽的核酸分子以及由这些基序组成的肽的鉴定。 还提供了针对肽和这些抗体与肽的免疫复合物特异性的抗体。 此外，本发明涉及用于使用本发明的核酸分子检测外消旋体的方法和试剂盒，以及由这些肽的基序和抗体组成的肽。
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6.发明授权Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins 有权在糖蛋白生产中消除聚糖的甘露糖基磷酸化的方法公开(公告)号：US07259007B2
公开(公告)日：2007-08-21
申请号：US11020808
申请日：2004-12-22
CPC分类号： C12N9/1051 , C07K14/39 , C12P21/005
摘要： The present invention relates to the elimination of mannosylphosphorylation on the glycans of glycoproteins in the yeast genus Pichia. The elimination of mannosylphosphorylated glycoproteins results from the disruption of the PNO1 gene and the newly isolated P. pastoris MNN4B gene. The present invention further relates to methods for producing modified glycan structures in host cells that are free of glycan mannosylphosphorylation.
摘要翻译： 本发明涉及消除酵母属毕赤酵母中糖蛋白聚糖上的甘露糖基磷酸化。 消除甘露糖基磷酸化糖蛋白是由PNO1基因和新分离的巴斯德毕赤酵母MNN4B基因的破坏产生的。 本发明还涉及在不含聚糖甘露糖基磷酸化的宿主细胞中产生修饰的聚糖结构的方法。
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7.发明授权Use of the repressor glxR for the synthesis of lysine in Corynebacterium glutamicum 有权在谷氨酸棒杆菌中使用阻遏物glxR用于合成赖氨酸公开(公告)号：US07192749B2
公开(公告)日：2007-03-20
申请号：US10514076
申请日：2003-05-13
申请人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Häfner , Heung-Shick Lee
发明人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Häfner , Heung-Shick Lee
CPC分类号： C07K14/34
摘要： Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.
摘要翻译： 具有SEQ ID NO：1的序列的分离的多肽序列或其突变蛋白具有结合cAMP的能力并抑制谷氨酸棒杆菌的aceB基因的表达，并且可以通过插入，缺失或替代从SEQ ID NO：1获得 高达20％的氨基酸。
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公开(公告)号：US07108973B2
公开(公告)日：2006-09-19
申请号：US10102548
申请日：2002-03-20
申请人： Ken-Shwo Dai
发明人： Ken-Shwo Dai
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/156
摘要： The invention relates to a novel human PEN11B-related gene variant, and to the use of the nucleic acid of the gene variant in diagnosing diseases, in particular, lung cancer, e.g. small cell lung cancer.
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