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    Process for the continuous production and coating of self-adhesive compositions based on polyisobutylene with at least one active pharmaceutical substance
    1.
    发明授权
    Process for the continuous production and coating of self-adhesive compositions based on polyisobutylene with at least one active pharmaceutical substance 失效
    基于聚异丁烯与至少一种活性药物物质连续生产和涂覆自粘组合物的方法

    公开(公告)号：US06555130B2

    公开(公告)日：2003-04-29

    申请号：US09759559

    申请日：2001-01-12

    申请人： Jens-Uwe Wüstling ,  Matthias Wasner ,  Joachim Kirchner ,  Reinhard Uphus ,  Sören Struckmann

    发明人： Jens-Uwe Wüstling ,  Matthias Wasner ,  Joachim Kirchner ,  Reinhard Uphus ,  Sören Struckmann

    IPC分类号： A61F1302

    CPC分类号： A61K9/7053 ,  A61K9/7076 ,  C09J7/381 ,  C09J2423/00

    摘要： A process for the continuous solvent-free and mastication-free production of self-adhesive compositions based on polyisobutylene with at least one active pharmaceutical substance in a continuously operating apparatus having a filling section and a compounding section, comprising the following steps: a) feeding an initial batch comprising granulated polyisobutylene, at least one release auxiliary and at least one active pharmaceutical substance into the filling section of the apparatus;  if desired, feeding low molecular mass polyisobutylene, fillers, plasticizers, tackifiers and/or resins, b) transferring the feed components of the self-adhesive composition from the filling section to the compounding section, c) if desired, adding the components of the self-adhesive composition that have not been introduced in the filling section, such as low molecular mass polyisobutylene, fillers, plasticizers, tackifiers and/or resins, to the compounding section, d) if desired, adding further pharmaceutical substances to the compounding section of the apparatus, e) preparing a homogeneous self-adhesive composition in the compounding section, and f) discharging the self-adhesive composition.

    摘要翻译： 一种在具有填充部分和配混部分的连续操作装置中连续无溶剂和无咀嚼形成基于聚异丁烯与至少一种活性药物物质的自粘组合物的方法，包括以下步骤：a） 包含颗粒状聚异丁烯，至少一种释放助剂和至少一种活性药物物质的初始批料进入装置的填充部分; 如果需要，进料低分子量聚异丁烯，填料，增塑剂，增粘剂和/或树脂，b）将自粘合剂组合物的进料组分从填充部分转移到复合部分，c）如果需要，加入 在配制部中未引入填充部分的低粘度组合物，例如低分子量聚异丁烯，填料，增塑剂，增粘剂和/或树脂，d）如果需要，向其配制部分添加其它药物 该装置，e）在配混部分中制备均匀的自粘组合物，和f）排出自粘组合物。