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    Process for the continuous production and coating of self-adhesive compositions based on polyisobutylene with at least one active pharmaceutical substance
    1.
    发明授权
    Process for the continuous production and coating of self-adhesive compositions based on polyisobutylene with at least one active pharmaceutical substance 失效
    基于聚异丁烯与至少一种活性药物物质连续生产和涂覆自粘组合物的方法

    公开(公告)号：US06555130B2

    公开(公告)日：2003-04-29

    申请号：US09759559

    申请日：2001-01-12

    申请人： Jens-Uwe Wüstling ,  Matthias Wasner ,  Joachim Kirchner ,  Reinhard Uphus ,  Sören Struckmann

    发明人： Jens-Uwe Wüstling ,  Matthias Wasner ,  Joachim Kirchner ,  Reinhard Uphus ,  Sören Struckmann

    IPC分类号： A61F1302

    CPC分类号： A61K9/7053 ,  A61K9/7076 ,  C09J7/381 ,  C09J2423/00

    摘要： A process for the continuous solvent-free and mastication-free production of self-adhesive compositions based on polyisobutylene with at least one active pharmaceutical substance in a continuously operating apparatus having a filling section and a compounding section, comprising the following steps: a) feeding an initial batch comprising granulated polyisobutylene, at least one release auxiliary and at least one active pharmaceutical substance into the filling section of the apparatus;  if desired, feeding low molecular mass polyisobutylene, fillers, plasticizers, tackifiers and/or resins, b) transferring the feed components of the self-adhesive composition from the filling section to the compounding section, c) if desired, adding the components of the self-adhesive composition that have not been introduced in the filling section, such as low molecular mass polyisobutylene, fillers, plasticizers, tackifiers and/or resins, to the compounding section, d) if desired, adding further pharmaceutical substances to the compounding section of the apparatus, e) preparing a homogeneous self-adhesive composition in the compounding section, and f) discharging the self-adhesive composition.

    摘要翻译： 一种在具有填充部分和配混部分的连续操作装置中连续无溶剂和无咀嚼形成基于聚异丁烯与至少一种活性药物物质的自粘组合物的方法，包括以下步骤：a） 包含颗粒状聚异丁烯，至少一种释放助剂和至少一种活性药物物质的初始批料进入装置的填充部分; 如果需要，进料低分子量聚异丁烯，填料，增塑剂，增粘剂和/或树脂，b）将自粘合剂组合物的进料组分从填充部分转移到复合部分，c）如果需要，加入 在配制部中未引入填充部分的低粘度组合物，例如低分子量聚异丁烯，填料，增塑剂，增粘剂和/或树脂，d）如果需要，向其配制部分添加其它药物 该装置，e）在配混部分中制备均匀的自粘组合物，和f）排出自粘组合物。

    Skin friendly active substance patch for transdermal administration of hyperemic active substances
    7.
    发明授权
    Skin friendly active substance patch for transdermal administration of hyperemic active substances 失效
    皮肤友好的活性物质补片，用于透皮给药充血活性物质

    公开(公告)号：US07001613B2

    公开(公告)日：2006-02-21

    申请号：US10436542

    申请日：2003-05-12

    申请人： Detlev Radloff ,  Matthias Wasner

    发明人： Detlev Radloff ,  Matthias Wasner

    IPC分类号： A61F13/02 ,  A61L15/16 ,  A61K9/14

    CPC分类号： A61K9/7053 ,  A61K9/7061

    摘要： An active substance matrix patch for controlled delivery of at least one hyperemic active substance to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitive adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and comprising: a) from 25 to 90% by weight of synthetic framework polymers based on polyisobutylene, b) from 5 to 40% by weight of amorphous poly-α-olefin, c) from 10 to 60% by weight of an insoluble hydrophilic filler having an average particle size of less than 100 μm, and d) from 0.001 to 20% by weight of the hyperemic active substance.

    摘要翻译： 一种活性物质基质贴剂，其用于将至少一种充满活性的物质控制递送至皮肤，包括柔性覆盖层和不溶于水的压敏粘合剂活性物质基质，其中所述粘合剂基质不含矿物油和增粘树脂，并且包括

    Active substance patch, kind to the skin, for transdermal administration of nonsteroidal antirheumatics
    9.
    发明授权
    Active substance patch, kind to the skin, for transdermal administration of nonsteroidal antirheumatics 失效
    活性物质贴片，适合皮肤，用于透皮给药非甾体抗风湿药

    公开(公告)号：US06652876B2

    公开(公告)日：2003-11-25

    申请号：US09745613

    申请日：2000-12-21

    申请人： Detlev Radloff ,  Matthias Wasner

    发明人： Detlev Radloff ,  Matthias Wasner

    IPC分类号： A61L1516

    CPC分类号： A61K9/7053 ,  A61K9/7076 ,  A61K31/192 ,  A61K31/196 ,  A61K31/5415 ,  Y10T442/2525

    摘要： An active substance matrix patch for controlled delivery of nonsteroidal antirheumatics to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitively adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and is composed of a) from 25 to 90% by weight of synthetic framework polymers based on polyisobutylene, b) from 5 to 40% by weight of amorphous poly-&agr;-olefin, c) from 10 to 60% by weight of an insoluble hydrophilic filler having an average particle size of less than 100 &mgr;m, and d) from 0.001 to 20% by weight of a drug.

    摘要翻译： 一种活性物质基质贴剂，其用于将非甾体抗风湿药物控制递送至皮肤，其包括柔性覆盖层和不溶于水的压敏敏感粘合剂活性物质基质，其中所述粘合剂基质不含矿物油和增粘树脂，并且由以下组成：a） 25至90重量％的基于聚异丁烯的合成骨架聚合物，b）5至40重量％的无定形聚-α-烯烃，c）10至60重量％的具有平均粒度的不溶性亲水填料 小于100mg，和d）0.001至20重量％的药物。