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    Marker comprising anti-CK8/18 complex autoantibody and its use for diagnosing cancer
    1.
    发明授权
    Marker comprising anti-CK8/18 complex autoantibody and its use for diagnosing cancer 有权
    包括抗CK8 / 18复合自身抗体及其用于诊断癌症的标记物

    公开(公告)号：US09234893B2

    公开(公告)日：2016-01-12

    申请号：US14000221

    申请日：2012-02-20

    申请人： Eun Wie Cho ,  Chang Gyu Heo ,  Jeong Heon Ko ,  Mi Kyung Woo ,  Hyang Sook Yoo ,  Hai Min Hwang

    发明人： Eun Wie Cho ,  Chang Gyu Heo ,  Jeong Heon Ko ,  Mi Kyung Woo ,  Hyang Sook Yoo ,  Hai Min Hwang

    IPC分类号： C07K16/18 ,  G01N33/574 ,  C07K7/06 ,  C07K16/30

    CPC分类号： G01N33/574 ,  C07K7/06 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/32 ,  C07K2317/34 ,  G01N33/57415 ,  G01N2333/4742

    摘要： The present invention relates to a cytokeratin 8/18 complex-specific autoantibody or a fragment comprising an antigen-binding site (paratope) thereof, the use thereof in the diagnosis of breast cancer, a polypeptide having an amino acid sequence of an epitope specifically binding to the autoantibody, a composition for diagnosing breast cancer comprising an agent capable of measuring an expression level of the autoantibody or the fragment comprising an antigen-binding site thereof, a hybridoma cell line producing the autoantibody, and a kit for diagnosing breast cancer comprising the composition of the present invention. Further, the present invention relates to a method for diagnosing breast cancer, comprising the step of detecting the cytokeratin 8/18 complex-specific autoantibody or the fragment comprising the antigen-binding site thereof using the composition of the present invention, and a method for screening a therapeutic agent for breast cancer using the autoantibody.

    摘要翻译： 本发明涉及细胞角蛋白8/18复合物特异性自身抗体或包含其抗原结合位点（其相互作用）的片段，其在乳腺癌诊断中的应用，具有表位特异性结合的表位氨基酸序列的多肽 涉及自身抗体的用于诊断乳腺癌的组合物，其包含能够测量自身抗体表达水平的试剂或包含其抗原结合位点的片段，产生该自身抗体的杂交瘤细胞系和用于诊断乳腺癌的试剂盒， 本发明的组合物。 此外，本发明涉及一种诊断乳腺癌的方法，包括使用本发明的组合物检测细胞角蛋白8/18复合物特异性自身抗体或包含其抗原结合位点的片段的方法， 使用自身抗体筛选乳腺癌的治疗剂。

    MARKER COMPRISING ANTI-CK8/18 COMPLEX AUTOANTIBODY AND ITS USE FOR DIAGNOSING CANCER
    3.
    发明申请
    MARKER COMPRISING ANTI-CK8/18 COMPLEX AUTOANTIBODY AND ITS USE FOR DIAGNOSING CANCER 有权
    包含抗CK8 / 18复合自身抗体的标记及其用于诊断癌症的用途

    公开(公告)号：US20140093892A1

    公开(公告)日：2014-04-03

    申请号：US14000221

    申请日：2012-02-20

    申请人： Eun Wie Cho ,  Chang Gyu Heo ,  Jeong Heon Ko ,  Mi Kyung Woo ,  Hyang Sook Yoo ,  Hai Min Hwang

    发明人： Eun Wie Cho ,  Chang Gyu Heo ,  Jeong Heon Ko ,  Mi Kyung Woo ,  Hyang Sook Yoo ,  Hai Min Hwang

    IPC分类号： G01N33/574 ,  C07K7/06 ,  C07K16/18

    CPC分类号： G01N33/574 ,  C07K7/06 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/32 ,  C07K2317/34 ,  G01N33/57415 ,  G01N2333/4742

    摘要： The present invention relates to a cytokeratin 8/18 complex-specific autoantibody or a fragment comprising an antigen-binding site (paratope) thereof, the use thereof in the diagnosis of breast cancer, a polypeptide having an amino acid sequence of an epitope specifically binding to the autoantibody, a composition for diagnosing breast cancer comprising an agent capable of measuring an expression level of the autoantibody or the fragment comprising an antigen-binding site thereof, a hybridoma cell line producing the autoantibody, and a kit for diagnosing breast cancer comprising the composition of the present invention. Further, the present invention relates to a method for diagnosing breast cancer, comprising the step of detecting the cytokeratin 8/18 complex-specific autoantibody or the fragment comprising the antigen-binding site thereof using the composition of the present invention, and a method for screening a therapeutic agent for breast cancer using the autoantibody.

    摘要翻译： 本发明涉及细胞角蛋白8/18复合物特异性自身抗体或包含其抗原结合位点（其相互作用）的片段，其在乳腺癌诊断中的应用，具有表位特异性结合的表位氨基酸序列的多肽 涉及自身抗体的用于诊断乳腺癌的组合物，其包含能够测量自身抗体表达水平的试剂或包含其抗原结合位点的片段，产生该自身抗体的杂交瘤细胞系和用于诊断乳腺癌的试剂盒， 本发明的组合物。 此外，本发明涉及一种诊断乳腺癌的方法，包括使用本发明的组合物检测细胞角蛋白8/18复合物特异性自身抗体或包含其抗原结合位点的片段的方法， 使用自身抗体筛选乳腺癌的治疗剂。

    Method of diagnosing the chances of pregnancy and the diagnostic kit for the same
    8.
    发明授权
    Method of diagnosing the chances of pregnancy and the diagnostic kit for the same 失效
    诊断妊娠机会的方法及其诊断试剂盒

    公开(公告)号：US07060502B2

    公开(公告)日：2006-06-13

    申请号：US10652116

    申请日：2003-08-29

    申请人： Cheorl-Ho Kim ,  Dong-Mok Lee ,  Tae-Wook Chung ,  Jeong-Heon Ko

    发明人： Cheorl-Ho Kim ,  Dong-Mok Lee ,  Tae-Wook Chung ,  Jeong-Heon Ko

    IPC分类号： G01N33/48 ,  G01N33/53

    CPC分类号： G01N33/689 ,  C12Q1/37 ,  G01N2333/96486 ,  G01N2800/368

    摘要： Disclosed is a method of diagnosing the chances of pregnancy and the diagnostic kit for the method. In the present invention, follicular fluid is retrieved from the women who attended the in vitro fertilization program and matrix metalloproteinase activity is measured. According to the present invention, the chance of pregnancy in the group with low matrix metalloproteinase-9 activity is zero whereas in the group with high matrix metalloproteinase-9 activity, the chances are 50-60%. Therefore it is possible to predict the chances of pregnancy in assisted reproduction technology by measuring the degree of matrix metalloproteinase-9 expression by using the method and kit of the present invention enhancing the efficiency of assisted reproduction technology.

    摘要翻译： 公开了一种诊断怀孕机会的方法和该方法的诊断试剂盒。 在本发明中，从参加体外受精程序的妇女中检索滤泡液，并测量基质金属蛋白酶活性。 根据本发明，在具有低基质金属蛋白酶-9活性的组中怀孕的机会为零，而在具有高基质金属蛋白酶-9活性的组中，机会为50-60％。 因此，通过使用提高辅助生殖技术效率的本发明的方法和试剂盒来测量基质金属蛋白酶-9表达的程度，可以预测辅助生殖技术中怀孕的机会。