公开(公告)号：US20240280589A1

公开(公告)日：2024-08-22

申请号：US18391104

申请日：2023-12-20

申请人： Sinai Health System ,  The Hospital for Sick Children

发明人： Isabella Caniggia ,  Martin Post ,  Sruthi Alahari

IPC分类号： G01N33/68

CPC分类号： G01N33/689 ,  G01N2333/78 ,  G01N2333/90245 ,  G01N2800/368

摘要： A method and kit for predicting preeclampsia is provided. Levels of Jumonji C domain containing protein 6 (JMJD6) and fibronectin are measured in placenta-derived small extracellular vesicles isolated from a subject. The levels of JMJD6 and fibronectin are compared to a non-preeclamptic control. If levels of JMJD6 are depressed and levels of fibronectin are elevated, the subject may be monitored or treated for preeclampsia.

公开(公告)号：US20240085432A1

公开(公告)日：2024-03-14

申请号：US17754756

申请日：2020-10-09

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Brian J. Koos

IPC分类号： G01N33/68 ,  G01N30/72 ,  G01N33/53

CPC分类号： G01N33/689 ,  G01N30/7233 ,  G01N33/5308 ,  G01N2030/8813 ,  G01N2800/042 ,  G01N2800/368

摘要： Described herein are methods, materials, kits, devices, and assays for use in screening, detection, and treatment of diabetes, including diabetes mellitus and gestational diabetes mellitus (GDM). The amount of a plurality of metabolic markers present in a test sample obtained from the subject is measured, followed by comparing the amount of the metabolic markers present in the test sample to reference levels of the markers; and identifying a subject as susceptible to, or as having, diabetes when the amount of each of the measured markers present in the test sample is increased or decreased relative to the reference levels. Also provided is a method of treating diabetes in a subject when the amount of each of the measured markers present in the test sample is increased or decreased relative to the reference levels.

公开(公告)号：US11906528B2

公开(公告)日：2024-02-20

申请号：US17525717

申请日：2021-11-12

申请人： Wayne State University ,  The United States of America, as Represented by the Secretary, Department of Health & Human Service

发明人： Adi L. Tarca ,  Piya Chaemsaithong ,  Tinnakorn Chaiworapongsa ,  Sonia S. Hassan ,  Roberto Romero

IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G06F17/18 ,  G16B5/00 ,  G16B5/20

CPC分类号： G01N33/689 ,  G01N33/543 ,  G06F17/18 ,  G16B5/00 ,  G16B5/20 ,  C12Y101/01205 ,  C12Y504/02 ,  G01N2333/4727 ,  G01N2800/368

摘要： Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.

公开(公告)号：US11844808B2

公开(公告)日：2023-12-19

申请号：US16961085

申请日：2019-01-16

申请人： Women & Infants Hospital of Rhode Island

发明人： Surendra Sharma

IPC分类号： A61K31/7016 ,  A61P9/12 ,  A61P15/00 ,  G01N33/68

CPC分类号： A61K31/7016 ,  A61P9/12 ,  A61P15/00 ,  G01N33/689 ,  G01N2800/368 ,  G01N2800/52

摘要： Methods and compositions using trehalose or a derivative or prodrug thereof for treating pre-eclampsia in a subject are disclosed.

公开(公告)号：US20230341414A1

公开(公告)日：2023-10-26

申请号：US18315230

申请日：2023-05-10

申请人： Wayne State University ,  The United States of America as Represented by the Secretary, Dept. of Health and Human Services

发明人： Tinnakorn Chaiworapongsa ,  Roberto Romero ,  Sonia S. Hassan

IPC分类号： G01N33/68 ,  C12Q1/6883 ,  G16H10/40 ,  G16H50/30 ,  A61K31/22 ,  A61K31/616 ,  A61K31/727 ,  G16H20/10

CPC分类号： G01N33/689 ,  C12Q1/6883 ,  G01N33/6872 ,  G16H10/40 ,  G16H50/30 ,  A61K31/22 ,  A61K31/616 ,  A61K31/727 ,  G16H20/10 ,  C12Q2600/158 ,  G01N2800/368 ,  G01N2333/475 ,  G01N2333/912 ,  G01N2800/50

摘要： Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.

公开(公告)号：US20230152332A1

公开(公告)日：2023-05-18

申请号：US17916414

申请日：2021-03-30

申请人： UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

发明人： Patricia MAGUIRE ,  Paulina SZKLANNA ,  Fionnuala NÍ ÁINLE

IPC分类号： G01N33/68

CPC分类号： G01N33/689 ,  G01N2800/368 ,  G01N2800/52 ,  G01N2333/4716 ,  G01N2333/948

摘要： The present invention relates to a method of diagnosing and/or prognosing preeclampsia. Specifically, the method involves determining the quantitative level of one or more biomarkers in a biological sample from the subject and either diagnosing preeclampsia; prognosing unstable moderate early-onset preeclampsia; and/or diagnosing preeclampsia and prognosing unstable moderate early-onset preeclampsia in the subject.

公开(公告)号：US20180246096A1

公开(公告)日：2018-08-30

申请号：US15970391

申请日：2018-05-03

申请人： The Trustees of Columbia University in the City of New York

发明人： Yiping HAN

IPC分类号： G01N33/569 ,  G01N33/574 ,  C07K16/12

CPC分类号： G01N33/56916 ,  C07K16/12 ,  C12Q1/689 ,  G01N33/56911 ,  G01N33/57419 ,  G01N33/57484 ,  G01N2469/20 ,  G01N2800/065 ,  G01N2800/368 ,  G01N2800/60

摘要： The present invention relates to detecting serum anti-FadA antibodies in test samples from a patient. Additionally, aspects of the present invention provide the basis for detection of serum anti-FadA antibody levels from test samples and correlation with various conditions of clinical relevance.

公开(公告)号：US20180180625A1

公开(公告)日：2018-06-28

申请号：US15850813

申请日：2017-12-21

申请人： Parsagen Diagnostics, Inc.

发明人： Ruben Salinas ,  Anthony Ausiello

IPC分类号： G01N33/68 ,  G01N33/577

CPC分类号： G01N33/689 ,  A61B2010/0074 ,  G01N33/577 ,  G01N2333/471 ,  G01N2800/368

摘要： A method of determining suitability of a pregnant woman to be a candidate for induction of labor can include: obtaining a vaginal fluid sample from a pregnant woman; contacting the vaginal fluid sample with a PAMG-1 antibody that binds with PAMG-1; detecting whether the PAMG-1 antibody binds with PAMG-1 in the vaginal fluid sample to form a PAMG-1-antibody complex; and providing the determination of suitability for induction of labor to the pregnant woman. When the PAMG-1-antibody complex forms, the pregnant woman is determined to be in a condition that is not suitable for induction of labor because PAMG-1 is detected in the vaginal sample. When the PAMG-1-antibody complex does not form, the pregnant woman is determined to be in a condition that is suitable to be a candidate for induction of labor because the PAMG-1 is not detected in the vaginal sample.

公开(公告)号：US20180156815A1

公开(公告)日：2018-06-07

申请号：US15886698

申请日：2018-02-01

申请人： Wallac Oy

发明人： Pertti Hurskainen ,  Teemu Korpimäki ,  Heikki Kouru ,  Mikko Sairanen

IPC分类号： G01N33/68

CPC分类号： G01N33/689 ,  G01N2333/7151 ,  G01N2333/8132 ,  G01N2800/042 ,  G01N2800/368 ,  G01N2800/54

摘要： A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.

公开(公告)号：US09983215B2

公开(公告)日：2018-05-29

申请号：US15386714

申请日：2016-12-21

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： David W. Speicher ,  Kurt T. Barnhart ,  Lynn A. Beer

IPC分类号： G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6893 ,  C07K14/705 ,  G01N33/76 ,  G01N2333/471 ,  G01N2333/70503 ,  G01N2560/00 ,  G01N2800/368 ,  G01N2800/60

摘要： Methods and compositions are provided for diagnosing ectopic pregnancy in a mammalian subject by detecting changes in expression of the selected genes, gene fragments or transcripts or expression products, or changes in the expression levels of one or more of proteins or peptide fragments, identified in Table 2 and FIGS. 8 and 9 herein. A selected gene, gene transcript or protein/peptide expression product, or profiles or signatures formed by combinations of same, detected in a biological fluid, preferably sera, of a subject, enables comparison of the corresponding genes, proteins or profiles from that of a reference or control having a normal intrauterine pregnancy. Detection of characteristic changes in the gene profile or protein expression signature of the subject is correlated with a diagnosis of ectopic pregnancy. Various compositions for use in such diagnosis include PCR primer-probe sets or ligands, labeled or immobilized, which are capable of detecting the changes in expression or translation of these targets.